The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
The zebrafish as a model to study intestinal inflammation
Open accessAbstract
Starting out as a model for developmental biology, during the last decade, zebrafish have also gained the attention of the immunologists and oncologists. Due to its small size, high fecundity and full annotation of its genome, the zebrafish is an attractive model system. The fact that fish are transparent early in life combined with the growing list of immune cell reporter fish, enables in vivo tracking of immune responses in a complete organism. Since zebrafish develop ex utero from a fertilized egg, immune development can be monitored from the start of life. Given that several gut functions and immune genes are conserved between zebrafish and mammals, the zebrafish is an interesting model organism to investigate fundamental processes underlying intestinal inflammation and injury. This review will first provide some background on zebrafish intestinal development, bacterial colonization and immunity, showing the similarities and differences compared to mammals. This will be followed by an overview of the existing models for intestinal disease, and concluded by future perspectives in light of the newest technologies and insights. • Zebrafish have innate and adaptive immunity. • Zebrafish intestinal morphology is highly homologues to that of higher vertebrates. • Intestinal inflammation in zebrafish is dependent on the microbiota. • Novel genetic editing techniques enable analysis of IBD susceptibility genes.
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Cited by
Qiao, R., Sheng, C., Lu, Y., Zhang, Y., Ren, H., & Lemos, B. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.01.245 · Cited by 965
Use of Zebrafish in Drug Discovery Toxicology
Cassar, S., Adatto, I., Freeman, J. L., Gamse, J. T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R. T., Van Cruchten, S., & Zon, L. I. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00335 · Cited by 561
Løvmo, S. D., Speth, M. T., Repnik, U., Koppang, E. O., Griffiths, G. W., & Hildahl, J. P. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.06.016 · Cited by 41
Lee, J.-G., Lee, S., Jeon, J., Kong, H. G., Cho, H.-J., Kim, J.-H., Kim, S.-Y., Oh, M. J., Lee, D., Seo, N., et al. (2022) · Microbiome · doi:10.1186/s40168-021-01191-x · Cited by 26
Metadata
- Authors
- Brugman, S.
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 64
- Pages
- 82-92
- ISSN
- 0145-305X (ISSN-L)
- OpenAlex
- W2276727190
- Cited by
- 308
- References
- 96
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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