Translocation of nanoparticles and Mycobacterium marinum across the intestinal epithelium in zebrafish and the role of the mucosal immune system
Abstract
Nano- and microparticles are promising carrier systems for oral delivery of drugs or vaccines, particularly in fish aquaculture. However, the mechanisms of uptake, trans-epithelial transport and immune response to nano/micrometer sized particles, or microorganisms such as bacteria are poorly understood in fish. Here, adult zebrafish were used to study the uptake of different nano- and microparticles and the pathogenic bacteria Mycobacterium marinum in the intestine, and their interactions with epithelial cells and the mucosal immune system. Fluorescent particles or bacteria were delivered directly into the adult zebrafish intestine by oral intubation and their localization was imaged in intestine, liver and spleen sections. Zebrafish do not appear to have M-cells, but both nanoparticles and bacteria were rapidly taken up in the intestine and transported to the liver and spleen. In each tissue, both bacteria and particles largely localized to leukocytes, presumably macrophages.
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Mechanisms of translocation have been proposed for micro- and nanoplastic particles, including by vesicular processes such as endocytosis by enterocytes.
“Mechanisms of translocation have been proposed for micro- and nanoplastic particles, including by vesicular processes, such as endocytosis19 by enterocytes.20”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [20]
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- Authors
- Løvmo, S. D., Speth, M. T., Repnik, U., Koppang, E. O., Griffiths, G. W., & Hildahl, J. P.
- Affiliations
- University of Oslo (NO)
- Norwegian University of Life Sciences (NO)
- Corresponding author
- Griffiths, Gareth Wyn
- Venue
- Developmental & Comparative Immunology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 67
- Pages
- 508-518
- ISSN
- 0145-305X (ISSN-L)
- OpenAlex
- W2468720188
- Cited by
- 41
- References
- 79
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental & Comparative Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Norwegian Research Council (143575, 143686)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- nanoparticle translocation, Mycobacterium marinum, intestinal epithelium, zebrafish, mucosal immune system, oral drug delivery, fish farming, M cells, macrophages, leukocytes, intestinal absorption, oral immunization
- MeSH terms
- Animals, Biological Transport, Cells, Cultured, Fish Diseases, Intestinal Mucosa, Mycobacterium Infections, Nontuberculous, Zebrafish, Drug Delivery Systems, Antigen Presentation, Immunity, Mucosal, Bacterial Translocation, Mycobacterium marinum, Enterocytes, Nanoparticles, Transendothelial and Transepithelial Migration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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