The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application
Abstract
OBJECTIVE A novel copper-bearing titanium alloy (Ti-Cu) was fabricated for dental application that is expected to efficiently restrain the growth of bacteria and discourage biofilm formation. The aim of this study was to investigate both the antibacterial activity and biofilm inhibition of Ti-Cu alloy in vitro, and the antibacterial effect of Ti-Cu implant in early stage of peri-implantitis in vivo. METHODS Staphylococcus aureus and Escherichia coli were selected to evaluate the antibacterial activity of Ti-Cu alloy and Ti served as control. The antibacterial rate, attached bacteria and developed biofilms were studied from quantitative antibacterial test, biofilm observation and bacterial morphological examination. Electrochemical tests were used to investigate the corrosion property of Ti-Cu alloy. Furthermore, both Ti and Ti-Cu dental implants were manufactured and then implanted in the mandibular premolar sites of beagle dogs for 3 months with ligature-infected treatment. Implant-tissue samples were prepared for radiographic analysis, Micro-CT evaluation and histological examination. RESULTS Ti-Cu alloy was found to efficiently kill the attached bacteria by ways of damaging cell membranes and cell walls and strongly inhibit the biofilm formation. However, Ti-Cu alloy had excellent corrosion resistance similar with Ti. Further, Ti-Cu dental implants showed superior capacities of inhibiting the bone resorption caused by bacterial infection and enhancing bone formation. SIGNIFICANCE Ti-Cu alloy strongly inhibited biofilm formation in vitro and prevented bacterial infection associated with dental implant in vivo, making it great potential for application in dental implants with excellent antibacterial viability and positive effect against bone resorption induced by peri-implantitis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polysaccharide-based antibiofilm surfaces
Junter, G.-A., Thébault, P., & Lebrun, L. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.010 · Cited by 215
Prevention of pin tract infection with titanium‐copper alloys
Shirai, T., Tsuchiya, H., Shimizu, T., Ohtani, K., Zen, Y., & Tomita, K. (2009) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.31412 · Cited by 199
Cited by
Antimicrobial Copper-Based Materials and Coatings: Potential Multifaceted Biomedical Applications
Mitra, D., Kang, E.-T., & Neoh, K. G. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17815 · Cited by 322
Metadata
- Authors
- Liu, R., Tang, Y., Zeng, L., Zhao, Y., Ma, Z., Sun, Z., Xiang, L., Ren, L., & Yang, K.
- Venue
- Dental Materials
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 34
- Issue
- 8
- Pages
- 1112-1126
- ISSN
- 0109-5641 (ISSN-L)
- OpenAlex
- W2800488516
- Cited by
- 198
- References
- 2
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application. https://app.cochat.ai/papers/10.1016/j.dental.2018.04.007
- The paper
- Liu, R., Tang, Y., Zeng, L., Zhao, Y., Ma, Z., Sun, Z., Xiang, L., Ren, L., & Yang, K. (2018). In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application. Dental Materials. https://doi.org/10.1016/j.dental.2018.04.007
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
