Polysaccharide-based antibiofilm surfaces
Abstract
Surface treatment by natural or modified polysaccharide polymers is a promising means to fight against implant-associated biofilm infections. The present review focuses on polysaccharide-based coatings that have been proposed over the last ten years to impede biofilm formation on material surfaces exposed to bacterial contamination. Anti-adhesive and bactericidal coatings are considered. Besides classical hydrophilic coatings based on hyaluronic acid and heparin, the promising anti-adhesive properties of the algal polysaccharide ulvan are underlined. Surface functionalization by antimicrobial chitosan and derivatives is extensively surveyed, in particular chitosan association with other polysaccharides in layer-by-layer assemblies to form both anti-adhesive and bactericidal coatings.Statement of significance Bacterial contamination of surfaces, leading to biofilm formation, is a major problem in fields as diverse as medicine, first, but also food and cosmetics. Many prophylactic strategies have emerged to try to eliminate or reduce bacterial adhesion and biofilm formation on surfaces of materials exposed to bacterial contamination, in particular implant materials. Polysaccharides are widely distributed in nature. A number of these natural polymers display antibiofilm properties. Hence, surface treatment by natural or modified polysaccharides is a promising means to fight against implant-associated biofilm infections. The present manuscript is an in-depth look at polysaccharide-based antibiofilm surfaces that have been proposed over the last ten years. This review, which is a novelty compared to published literature, will bring well documented and updated information to readers of Acta Biomaterialia.
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This EPS may have acted as an anionic surfactant and reduced the binding affinity of the tested bacteria to hydrocarbons.
“As such, this EPS may have acted as an anionic surfactant and reduced the binding affinity of the tested bacteria to hydrocarbons [53].”
From Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics (2022) · cites this paper as [53]
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“As such, this EPS may have acted as an anionic surfactant and reduced the binding affinity of the tested bacteria to hydrocarbons [53].”
Background
- Authors
- Junter, G.-A., Thébault, P., & Lebrun, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Junter, Guy-Alain
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 30
- Pages
- 13-25
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2153189401
- Cited by
- 215
- References
- 120
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 17 · 2023: 8 · 2022: 26 · 2021: 27 · 2020: 24 · 2019: 27 · 2018: 27 · 2017: 22 · 2016: 11
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- antibiofilm surfaces, polysaccharide coatings, bacterial adhesion, anti-adhesive coatings, bactericidal coatings, ulvan, chitosan, layer-by-layer assembly, hyaluronic acid, heparin, algal polysaccharides, surface functionalization
- MeSH terms
- Animals, Anti-Bacterial Agents, Humans, Bacterial Physiological Phenomena, Biofilms, Coated Materials, Biocompatible, Chitosan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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