The transcriptional control of trunk neural crest induction, survival, and delamination
Open accessAbstract
Trunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of transcription induce these properties in premigratory neural crest cells. Sox9 acts to provide the competence for neural crest cells to undergo an EMT and is required for trunk neural crest survival. In the absence of Sox9, cells apoptose prior to or shortly after delamination. Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration. Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells.
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SOX9 is crucial for EMT and EndMT.
“SOX9 is also crucial for processes involving epithelial-to-mesenchymal transition (EMT) and the closely related process endothelial-to-mesenchymal transition (EndMT) (10–12).”
From SOX9 reprograms endothelial cells by altering the chromatin landscape (2022) · cites this paper as [12]
Cites
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Self-citationThe transcription factor Sox9 is required for cranial neural crest development in<i>Xenopus</i>
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Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
Akiyama, H., Chaboissier, M.-C., Behringer, R. R., Rowitch, D. H., Schedl, A., Epstein, J. A., & de Crombrugghe, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401711101 · Cited by 265 · see citing works
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Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works
Epithelial-mesenchymal transitions: insights from development
Lim, J., & Thiery, J. P. (2012) · Development · doi:10.1242/dev.071209 · Cited by 661 · see citing works
Establishing neural crest identity: a gene regulatory recipe
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Shakhova, O., Cheng, P., Mishra, P. J., Zingg, D., Schaefer, S. M., Debbache, J., Häusel, J., Matter, C., Guo, T., Davis, S., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004877 · Cited by 111 · see citing works
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SOX9 reprograms endothelial cells by altering the chromatin landscape
Fuglerud, B. M., Drissler, S., Lotto, J., Stephan, T. L., Thakur, A., Cullum, R., & Hoodless, P. A. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac652 · Cited by 35 · see citing works
- Authors
- Cheung, M., Chaboissier, M.-C., Mynett, A., Hirst, E., Schedl, A., & Briscoe, J.
- Affiliations
- National Institute for Medical Research (GB)
- Inserm (FR)
- Corresponding author
- Briscoe, James
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 8
- Issue
- 2
- Pages
- 179-192
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2057967850
- Cited by
- 427
- References
- 3
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 21 · 2023: 11 · 2022: 16 · 2021: 8 · 2020: 18 · 2019: 17 · 2018: 20 · 2017: 21 · 2016: 21 · 2015: 21 · 2014: 21 · 2013: 28 · 2012: 29
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3088 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- European Commission (QLG2-CT-2001-01467, QLG3-CT-2002-01141)
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- trunk neural crest, neural crest induction, neural crest delamination, epithelial-mesenchymal transition, SOX9, FOXD3, transcriptional regulation, apoptosis, cell-cell adhesion molecules, neural crest migration, neural plate border, transcription factors
- MeSH terms
- Snail Family Transcription Factors, Animals, Chick Embryo, DNA-Binding Proteins, Embryonic Induction, Epithelium, High Mobility Group Proteins, Mesoderm, Models, Biological, Neural Crest, Repressor Proteins, Transcription Factors, Transcription, Genetic, Transfection, Apoptosis, Mice, Knockout, Gene Expression Regulation, Developmental, rhoB GTP-Binding Protein, Mice, Forkhead Transcription Factors, SOX9 Transcription Factor
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