Cited by 62Developmental Biology and Gene RegulationCancer Cells and MetastasisMechanisms of cancer metastasis

Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration

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Powell, Davalyn R., Blasky, Alex J., Britt, Steven G., Artinger, Kristin B.·2013·WIREs Systems Biology and Medicine

Abstract

The neural crest (NC) is first induced as an epithelial population of cells at the neural plate border requiring complex signaling between bone morphogenetic protein, Wnt, and fibroblast growth factors to differentiate the neural and NC fate from the epidermis. Remarkably, following induction, these cells undergo an epithelial‐to‐mesenchymal transition (EMT), delaminate from the neural tube, and migrate through various tissue types and microenvironments before reaching their final destination where they undergo terminal differentiation. This process is mirrored in cancer metastasis, where a primary tumor will undergo an EMT before migrating and invading other cell populations to create a secondary tumor site. In recent years, as our understanding of NC EMT and migration has deepened, important new insights into tumorigenesis and metastasis have also been achieved. These discoveries have been driven by the observation that many cancers misregulate developmental genes to reacquire proliferative and migratory states. In this review, we examine how the NC provides an excellent model for studying EMT and migration. These data are discussed from the perspective of the gene regulatory networks that control both NC and cancer cell EMT and migration. Deciphering these processes in a comparative manner will expand our knowledge of the underlying etiology and pathogenesis of cancer and promote the development of novel targeted therapeutic strategies for cancer patients. WIREs Syst Biol Med 2013, 5:511–522. doi: 10.1002/wsbm.1224 This article is categorized under: Biological Mechanisms > Cell Fates Biological Mechanisms > Cell Signaling Developmental Biology > Developmental Processes in Health and Disease

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Authors
Powell, D. R., Blasky, A. J., Britt, S. G., & Artinger, K. B.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Artinger, Kristin B.
Venue
WIREs Systems Biology and Medicine
Publisher
Wiley
Published
2013-04-10
Volume
5
Issue
4
Pages
511-522
ISSN
  • 1939-005X (ISSN-L)
  • 1939-5094
OpenAlex
W2044600584
Cited by
62
References
103
Citations by year
2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 2
FWCI
0.63
Type
journal article
Language
en
Open access
Locations
  • WIREs Systems Biology and Medicine (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (R01EY018376)
  • National Institute of Dental and Craniofacial Research (F31DE022237, R01DE017699)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
neural crest, epithelial-mesenchymal transition, cell migration, metastasis, gene regulatory networks, BMP signaling, Wnt signaling, FGF signaling, neural plate border, carcinogenesis, comparative developmental biology
MeSH terms
Cell Adhesion, Cell Movement, Humans, Neoplasm Metastasis, Neoplasms, Neural Crest, Transcription Factors, Signal Transduction, Epithelial-Mesenchymal Transition

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