Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration
Open accessAbstract
The neural crest (NC) is first induced as an epithelial population of cells at the neural plate border requiring complex signaling between bone morphogenetic protein, Wnt, and fibroblast growth factors to differentiate the neural and NC fate from the epidermis. Remarkably, following induction, these cells undergo an epithelial‐to‐mesenchymal transition (EMT), delaminate from the neural tube, and migrate through various tissue types and microenvironments before reaching their final destination where they undergo terminal differentiation. This process is mirrored in cancer metastasis, where a primary tumor will undergo an EMT before migrating and invading other cell populations to create a secondary tumor site. In recent years, as our understanding of NC EMT and migration has deepened, important new insights into tumorigenesis and metastasis have also been achieved. These discoveries have been driven by the observation that many cancers misregulate developmental genes to reacquire proliferative and migratory states. In this review, we examine how the NC provides an excellent model for studying EMT and migration. These data are discussed from the perspective of the gene regulatory networks that control both NC and cancer cell EMT and migration. Deciphering these processes in a comparative manner will expand our knowledge of the underlying etiology and pathogenesis of cancer and promote the development of novel targeted therapeutic strategies for cancer patients. WIREs Syst Biol Med 2013, 5:511–522. doi: 10.1002/wsbm.1224 This article is categorized under: Biological Mechanisms > Cell Fates Biological Mechanisms > Cell Signaling Developmental Biology > Developmental Processes in Health and Disease
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ZEB1 plays a critical role in epithelial-mesenchymal transition in neural crest migration and glioblastoma.
“Previously, ZEB1 was shown to play a critical role in epithelial-mesenchymal transition in neural crest migration and glioblastoma83,84”
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Johnson, E. W. (2000) · The Anatomical Record · doi:10.1002/(sici)1097-0185(20000601)259:2 · Cited by 9 · see citing works
Expression of ADAM8 and its clinical values in diagnosis and prognosis of hepatocellular carcinoma
Jiang, C., Zhang, Y., Yu, H.-F., Yu, X., Zhou, S., & Tan, Y. (2012) · Tumor Biology · doi:10.1007/s13277-012-0477-1 · Cited by 8 · see citing works
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Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82 · see citing works
- Authors
- Powell, D. R., Blasky, A. J., Britt, S. G., & Artinger, K. B.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Artinger, Kristin B.
- Venue
- WIREs Systems Biology and Medicine
- Publisher
- Wiley
- Published
- 2013-04-10
- Volume
- 5
- Issue
- 4
- Pages
- 511-522
- ISSN
- 1939-005X (ISSN-L)
- 1939-5094
- PMC
- PMC3739939
- OpenAlex
- W2044600584
- Cited by
- 62
- References
- 103
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- WIREs Systems Biology and Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY018376)
- National Institute of Dental and Craniofacial Research (F31DE022237, R01DE017699)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- neural crest, epithelial-mesenchymal transition, cell migration, metastasis, gene regulatory networks, BMP signaling, Wnt signaling, FGF signaling, neural plate border, carcinogenesis, comparative developmental biology
- MeSH terms
- Cell Adhesion, Cell Movement, Humans, Neoplasm Metastasis, Neoplasms, Neural Crest, Transcription Factors, Signal Transduction, Epithelial-Mesenchymal Transition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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