A Five-Year Itch in TNF-α Cytotoxicity: The Time Factor Determines JNK Action
Open accessAbstract
The intricate interplay between NF-kappaB and JNK determines TNF-alpha cytotoxicity. In a recent Cell paper, report that prolonged JNK1 activation promotes TNF-alpha killing via E3 ligase-mediated degradation of the caspase 8 inhibitor cFLIP(L). On the other hand, Ventura et al. (2006) show in their recent Molecular Cell paper that transient JNK activation suppresses TNF-alpha-induced cell death.
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The duration and timing of JNK signals can affect whether cells live or die.
“In fact, subtle changes in timing and duration of JNK signaling can determine cell fate decisions (Lin, 2006), highlighting the critical importance of tight regulation.”
From Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases (2012) · cites this paper as Lin, 2006
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Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
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NF-κB Is Required for UV-Induced JNK Activation via Induction of PKCδ
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Étude du rôle du transporteur de phosphate inorganique PiT1/SLC20A1 dans l'inflammation
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- Authors
- Lin, A.
- Corresponding author
- Lin, Anning
- ORCID
- Lin, Anning
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 10
- Issue
- 3
- Pages
- 277-278
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2065135624
- Cited by
- 19
- References
- 9
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 1 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2731 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- TNF-alpha cytotoxicity, JNK1, NF-κB, caspase-8, E3 ubiquitin ligase, apoptosis
- MeSH terms
- Animals, Enzyme Activation, Time Factors, Tumor Necrosis Factor-alpha, NF-kappa B, Apoptosis, Intracellular Signaling Peptides and Proteins, Mitogen-Activated Protein Kinase 8, Inhibitor of Apoptosis Proteins, Mice, CASP8 and FADD-Like Apoptosis Regulating Protein
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