The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints
Open accessAbstract
Summary The mechanisms responsible for maintaining genomic methylation imprints in mouse embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding a KRAB zinc finger protein. Loss of just the zygotic function of Zfp57 causes partial neonatal lethality, while eliminating both maternal and zygotic functions of Zfp57 results in a highly penetrant embryonic lethality. In oocytes, absence of Zfp57 results in failure to establish maternal methylation imprints at the Snrpn imprinted region. Intriguingly, methylation imprints are re-acquired specifically at the maternally derived Snrpn imprinted region when the zygotic Zfp57 is present in embryos. This suggests that there may be DNA methylation-independent memory for genomic imprints. Zfp57 is also required for the post-fertilization maintenance of maternal and paternal methylation imprints at multiple imprinted domains. The effects on genomic imprinting are consistent with the maternal-zygotic lethality of Zfp57 mutants.
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Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
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De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
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Cited by
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.02.045 · Cited by 1,864
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065
“Recent evidence suggests that maintenance of 5mC at ICRs is perhaps conferred through targeting DNMT1 and/or DNMT3A to these regions by zinc finger transcription factor ZFP57 and its partner, KAP1 (also known as TRIM28) (Li et al., 2008; Messerschmidt et al., 2012; Quenneville et al., 2011).”
The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells
Seisenberger, S., Andrews, S., Krueger, F., Arand, J., Walter, J., Santos, F., Popp, C., Thienpont, B., Dean, W., & Reik, W. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.001 · Cited by 973
Genomic imprinting: the emergence of an epigenetic paradigm
Ferguson-Smith, A. C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3032 · Cited by 838
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Metadata
- Authors
- Li, X., Ito, M., Zhou, F., Youngson, N., Zuo, X., Leder, P., & Ferguson-Smith, A. C.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 15
- Issue
- 4
- Pages
- 547-557
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2035877973
- Cited by
- 647
- References
- 4
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, X., Ito, M., Zhou, F., Youngson, N., Zuo, X., Leder, P., & Ferguson-Smith, A. C. (2008). A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints. Developmental Cell. https://doi.org/10.1016/j.devcel.2008.08.014
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