The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis
Open accessAbstract
SUMMARY The spread of cancer during metastatic disease requires that tumor cells subvert normal regulatory networks governing cell motility to invade surrounding tissues and migrate toward blood and lymphatic vessels. Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) proteins regulate cell motility by controlling the geometry of assembling actin networks. Mena, an Ena/VASP protein, is upregulated in the invasive subpopulation of breast cancer cells. In addition, Mena is alternately spliced to produce an invasion isoform, MenaINV. Here we show that Mena and MenaINV promote carcinoma cell motility and invasiveness in vivo and in vitro, and increase lung metastasis. Mena and MenaINV potentiate epidermal growth factor (EGF)-induced membrane protrusion and increase the matrix degradation activity of tumor cells. Interestingly, MenaINV is significantly more effective than Mena in driving metastases and sensitizing cells to EGF-dependent invasion and protrusion. Upregulation of MenaINV could therefore enable tumor cells to invade in response to otherwise benign EGF stimulus levels.
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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,695
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Self-citationDirect Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
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Self-citationIntravital imaging of cell movement in tumours
Condeelis, J., & Segall, J. E. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1231 · Cited by 929
Self-citationAntagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility
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Self-citationMechanism of filopodia initiation by reorganization of a dendritic network
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Self-citationCritical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in Cancer
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Ena/VASP Proteins: Regulators of the Actin Cytoskeleton and Cell Migration
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Self-citationMolecular mechanisms of invadopodium formation
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Kitamura, T., Qian, B.-Z., & Pollard, J. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3789 · Cited by 1,158
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Bradley, R. K., & Anczuków, O. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00541-7 · Cited by 579
Directed cell invasion and migration during metastasis
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Metadata
- Authors
- Philippar, U., Roussos, E. T., Oser, M., Yamaguchi, H., Kim, H.-D., Giampieri, S., Wang, Y., Goswami, S., Wyckoff, J. B., Lauffenburger, D. A., Sahai, E., Condeelis, J. S., & Gertler, F. B.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 15
- Issue
- 6
- Pages
- 813-828
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1537208644
- Cited by
- 269
- References
- 42
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Philippar, U., Roussos, E. T., Oser, M., Yamaguchi, H., Kim, H.-D., Giampieri, S., Wang, Y., Goswami, S., Wyckoff, J. B., Lauffenburger, D. A., Sahai, E., Condeelis, J. S., & Gertler, F. B. (2008). A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis. Developmental Cell. https://doi.org/10.1016/j.devcel.2008.09.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
