The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut
Open accessAbstract
The primitive foregut is patterned in a manner that spatially promotes proper organ specification along the anterior-posterior foregut axis. However, the molecular pathways that specify foregut endoderm progenitors are poorly understood. We show that Wnt2/2b signaling is required to specify lung endoderm progenitors within the anterior foregut. Embryos lacking Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker of the lung endoderm. In contrast, other foregut endoderm derived organs including the thyroid, liver, and pancreas are correctly specified in Wnt2/2b null animals. We show that this phenotype is recapitulated by an endoderm restricted deletion of β-catenin, demonstrating that Wnt2/2b signaling through the canonical Wnt pathway is required to specify lung endoderm progenitors within the foregut. Moreover, activation of canonical Wnt/β-catenin signaling results in reprogramming of esophagus and stomach endoderm to a lung endoderm progenitor fate. Together, these data reveal that canonical Wnt2/2b signaling is uniquely required for specification of lung endoderm progenitors in the developing foregut.
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Citations
Cites
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
β-Catenin is critical for early postnatal liver growth
Apte, U., Zeng, G., Thompson, M. D., Muller, P., Micsenyi, A., Cieply, B., Kaestner, K. H., & Monga, S. P. S. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00359.2006 · Cited by 119
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Pacheco-Pinedo, E. C., Durham, A. C., Stewart, K. M., Goss, A. M., Lu, M. M., DeMayo, F. J., & Morrisey, E. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44871 · Cited by 164
Self-citationThe roles and regulation of TBX3 in development and disease
Khan, S. F., Damerell, V., Omar, R., Du Toit, M., Khan, M., Maranyane, H. M., Mlaza, M., Bleloch, J., Bellis, C., Sahm, B. D. B., et al. (2020) · Gene · doi:10.1016/j.gene.2019.144223 · Cited by 99
“For example, Wnt signalling depends on active Bmp signalling and the loss of Wnt2/2b leads to failure of trachea and branching lung formation and inactivation of the Bmp receptors Bmpr1a and Bmpr1b leads to tracheal agenesis and ectopic primary bronchi (Domyan et al., 2011; Goss et al., 2009).”
BackgroundLópez-Márquez, A., Carrasco-López, C., Fernández-Méndez, C., & Santisteban, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.654569 · Cited by 49
Metadata
- Authors
- Goss, A. M., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D., Lu, M. M., Yamaguchi, T. P., & Morrisey, E. E.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 17
- Issue
- 2
- Pages
- 290-298
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2070864748
- Cited by
- 447
- References
- 2
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
