β-Catenin is critical for early postnatal liver growth
Abstract
The Wnt/beta-catenin pathway plays an important role in embryonic liver development, morphogenesis, and organogenesis. Here, we report on the activation of beta-catenin during early postnatal liver growth. Modulation of beta-catenin expression was studied in CD-1 mice livers over a time course of 0 to 30 postnatal days (PD) and 3 mo. Increases in total and active beta-catenin were observed in developing livers from PD 5 to 20. A concomitant increase in the beta-catenin-transcription factor (TCF) complex along with nuclear and cytoplasmic beta-catenin was also evident, which coincided with ongoing hepatocyte proliferation by PCNA immunohistochemistry. This activation of beta-catenin was multifactorial, including cyclical inhibition of glycogen synthase kinase-3beta, suppression of casein kinase-IIalpha, and a transient increase in beta-catenin gene expression. Coprecipitation experiments revealed the formation of the beta-catenin-cadherin complex at PD 5, whereas adequate beta-catenin-c-Met complex at the hepatocyte membrane did not form until PD 20, which might be contributing to the free beta-catenin pool during early postnatal growth. Furthermore, beta-catenin liver-specific knockout mice exhibited smaller livers at PD 30, secondary to diminished hepatocyte proliferation. These data indicate that the activation of beta-catenin is critical for early postnatal liver growth and development.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hepatocytes in the postnatal liver expand rapidly in a Wnt/β-catenin signaling-dependent way.
“Hepatocytes in the postnatal liver expand rapidly in a Wnt/β-catenin signaling-dependent way (12–16).”
From Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade (2022) · cites this paper as [14]
The postnatal liver expands rapidly in a Wnt/βcatenin signaling-dependent way and switches from initially containing diploid hepatocytes to becoming mostly polyploid.
“The postnatal liver expands rapidly in a Wnt/βcatenin signaling-dependent way and switches from initially containing diploid hepatocytes to becoming mostly polyploid (Apte et al. 2007;Monga et al. 2001).”
From Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling (2021) · cites this paper as Apte et al. 2007
Cited by
Sorted by citations
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works
Grigoryan, T., Wend, P., Klaus‐Bergmann, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 558 · see citing works
Goss, A., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D. D., Lu, M. M., Yamaguchi, T. P., & Morrisey, E. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.005 · Cited by 447 · see citing works
Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad
Nejak-Bowen, K. N., & Monga, S. P. S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.12.010 · Cited by 260 · see citing works
Self-citationBoj, S. F., van Es, J. H., Huch, M., Li, V. S. W., José, A., Hatzis, P., Mokrý, M., Haegebarth, A., van den Born, M., Chambon, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.053 · Cited by 234 · see citing works
“The Wnt pathway controls postnatal hepatic growth (Apte et al., 2007) and postnatal liver zonation (Spear et al., 2006).”
BackgroundA New School in Liver Development: Lessons from Zebrafish
Chu, J., & Sadler, K. (2009) · Hepatology · doi:10.1002/hep.23157 · Cited by 232 · see citing works
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
Goessling, W., North, T. E., Lord, A. M., Ceol, C. J., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.-P. G., Puder, M., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.05.526 · Cited by 192 · see citing works
Tan, X., Yuan, Y., Zeng, G., Apte, U., Thompson, M. D., Cieply, B., Stolz, D. B., Michalopoulos, G. K., Kaestner, K. H., & Monga, S. P. S. (2008) · Hepatology · doi:10.1002/hep.22225 · Cited by 202 · see citing works
Self-citationIncreased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure
Wang, W.-H., McNatt, L. G., Pang, I., Millar, J. C., Hellberg, P. E., Hellberg, M. H., Steely, H. T., Rubin, J. S., Fingert, J. H., Sheffield, V. C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33871 · Cited by 178 · see citing works
“Wnts affect the growth and differentiation of various organs and systems, including the CNS (23, 28), liver (29), and kidney (30).”
BackgroundRole of Wnt/Beta-Catenin Signaling in Liver Metabolism and Cancer
Monga, S. (2009) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2009.09.001 · Cited by 167 · see citing works
“Wnt/β-catenin signaling was recently identified to be active during these stages and correlated well with ongoing hepatocyte proliferation (Apte et al., 2007).”
Self-citationBeta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury
Apte, U. M., Singh, S., Zeng, G., Cieply, B. W., Virji, M. A., Wu, T., & Monga, S. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080976 · Cited by 179 · see citing works
“To further confirm the relevance of -catenin activation in liver regeneration after APAP-injury, we decided to examine the -catenin conditional null mice ( -catenin; FP-Alb-Cre / , or KO) and wild-type ( -catenin; FP-Alb- Cre / or Con) littermates that are available in C57BL/6 background in our laboratory.(21,22) The…”
MethodSelf-citationNejak-Bowen, K., Thompson, M. D., Singh, S., Bowen, W., Dar, M. J., Khillan, J., Dai, C.-S., & Monga, S. P. S. (2010) · Hepatology · doi:10.1002/hep.23538 · Cited by 160 · see citing works
Self-citationProtein Kinase CK2 in Health and Disease
Dominguez, I., Sonenshein, G., & Seldin, D. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-9153-z · Cited by 140
Preziosi, M., Okabe, H., Poddar, M., Singh, S., & Monga, S. P. (2018) · Hepatology Communications · doi:10.1002/hep4.1196 · Cited by 135 · see citing works
“Our previous study showed the role of b-catenin in hepatocyte proliferation during early postnatal hepatic growth.((29)) Our current study thus suggests hepatic ECs may be the source of Wnts that induce b-catenin activation during early postnatal stages.”
BackgroundSelf-citationsiRNA-Mediated β-Catenin Knockdown in Human Hepatoma Cells Results in Decreased Growth and Survival*
Zeng, G., Apte, U., Cieply, B., Singh, S., & Monga, S. S. P. (2007) · Neoplasia · doi:10.1593/neo.07469 · Cited by 124 · see citing works
“Furthermore, b-catenin activation and cytoplasmic/nuclear localization have been associated with increased proliferation and survival of hepatocytes in normal physiology and tumor cell survival/ proliferation in HCC [2,20,21,26–28].”
BackgroundSelf-citationDifferentiation of progenitors in the liver: a matter of local choice
Boulter, L., Lu, W.-Y., & Forbes, S. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66026 · Cited by 116 · see citing works
“such suggests a conserved functional outcome of these signaling pathways during development and maturation (71).”
BackgroundLimaye, P. B., Bowen, W. C., Orr, A. V., Luo, J., Tseng, G. C., & Michalopoulos, G. K. (2008) · Hepatology · doi:10.1002/hep.22221 · Cited by 120 · see citing works
Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
Hart, S., Cui, Y., Klaassen, C., & Zhong, X.-B. (2009) · Drug Metabolism And Disposition · doi:10.1124/dmd.108.023812 · Cited by 111 · see citing works
“Mice have been used to study ontogenic expression of P450 genes (Choudhary et al., 2003, 2005).”
BackgroundMethodZhao, L., Jin, Y., Donahue, K., Tsui, M., Fish, M., Logan, C. Y., Wang, B., & Nusse, R. (2019) · Hepatology · doi:10.1002/hep.30563 · Cited by 111 · see citing works
“The Wnt/β-catenin signaling pathway has been implicated in the regulation of liver biology from normal development to disease (8-11).”
Backgroundβ-Catenin Regulates Hepatic Mitochondrial Function and Energy Balance in Mice
Lehwald, N., Tao, G., Jang, K. Y., Papandreou, I., Liu, B., Liu, B., Pysz, M. A., Willmann, J. K., Knoefel, W. T., Denko, N. C., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.048 · Cited by 102 · see citing works
Molecular Determinants of Liver Zonation
Torre, C., Perret, C., & Colnot, S. (2010) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-385233-5.00005-2 · Cited by 97 · see citing works
Crawford, L. J., Foley, J., & Elmore, S. (2010) · Toxicologic pathology (Print) · doi:10.1177/0192623310374329 · Cited by 92 · see citing works
“The adult liver has a characteristic histological architecture (Apte et al. 2007).”
BackgroundInfluentialWnt/β-catenin signaling in hepatic organogenesis
Nejak-Bowen, K., & Monga, S. P. S. (2008) · Organogenesis · doi:10.4161/org.4.2.5855 · Cited by 92 · see citing works
Self-citationWnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells
Bi, Y., Huang, J., He, Y., Zhu, G., Su, Y., He, B.-C., Luo, J., Wang, Y., Kang, Q., Luo, Q., et al. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22254 · Cited by 91
“, 2004], indicating that b-catenin activation is critical for early postnatal liver growth [Apte et al., 2007; Thompson and Monga, 2007].”
BackgroundWnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.
Cavard, C., Colnot, S., Audard, V., Benhamouche, S., Finzi, L., Torre, C., Grimber, G., Godard, C., Terris, B., & Perret, C. (2008) · Future Oncology · doi:10.2217/14796694.4.5.647 · Cited by 91 · see citing works
Torre, C., Perret, C., & Colnot, S. (2011) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2009.11.004 · Cited by 90 · see citing works
Beta-Catenin Signaling in Hepatic Development and Progenitors: Which Way Does the WNT Blow?
Lade, A. G., & Monga, S. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22522 · Cited by 90 · see citing works
“decreased relative to wildtypes between day 15 and day 20, and this decrease persists throughout the lives of the animals (Apte et al., 2007).”
BackgroundSelf-citationChafey, P., Finzi, L., Boisgard, R., Caüzac, M., Clary, G., Broussard, C., Pégorier, J., Guillonneau, F., Mayeux, P., Camoin, L., et al. (2009) · Proteomics · doi:10.1002/pmic.200800609 · Cited by 90 · see citing works
“More recently, the Wnt/b-catenin signaling has emerged as a key pathway in essential physiological processes: development [6], growth [7], regeneration [8, 9] and metabolism [10].”
BackgroundMicroRNA‐122 regulates polyploidization in the murine liver
Hsu, S., Delgado, E. R., Otero, P. A., Teng, K., Kutay, H., Meehan, K. M., Moroney, J. B., Monga, J. K., Hand, N. J., Friedman, J. R., et al. (2016) · Hepatology · doi:10.1002/hep.28573 · Cited by 84 · see citing works
“The transient differential expression of numerous miRNAs is not surprising because livers undergo profound changes during postnatal development, including acquisition of “adult” drug-metabolizing and metabolic processes, expansion of hepatocytes and bile duct epithelial cells, and loss of fetal hematopoietic cells.((2…”
Thomson, J. P., Hunter, J. M., Lempiäinen, H., Müller, A., Terranova, R., Moggs, J. G., & Meehan, R. R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt232 · Cited by 87 · see citing works
“Liver mass is known to increase 3-fold between the day of birth (19 days postcoitus) to postnatal day 9, rapid cellular proliferation can be observed up to day 20, but by postnatal day 30, mouse livers are histologically identical to livers of mice at 3 months of age (50,51).”
Conforto, T. L., & Waxman, D. J. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-9 · Cited by 88 · see citing works
“b-catenin, a gene associated with cell proliferation, is induced at postnatal day 5 and highly expressed until postnatal day 20 [9].”
BackgroundMatsumoto, K., Miki, R., Nakayama, M., Tatsumi, N., & Yokouchi, Y. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.021 · Cited by 75 · see citing works
“, 2004); second, for postnatal proliferation of hepatocytes within the first month after birth (Apte et al., 2007).”
BackgroundHGF/c-Met related activation of β-catenin in hepatoblastoma
Purcell, R., Childs, M., Maibach, R., Miles, C., Turner, C., Zimmermann, A., & Sullivan, M. J. (2011) · Journal of experimental & clinical cancer research : CR · doi:10.1186/1756-9966-30-96 · Cited by 71 · see citing works
“Canonical Wnt/b-catenin signaling directly alters gene expression and is a key regulator of cell proliferation, differentiation, and apoptosis during normal liver development, so mutation or deletion within the b-catenin gene suggests a crucial role of this pathway in the origins of embryonal liver tumors [22,23](13-1…”
BackgroundPettinato, G., Ramanathan, R., Fisher, R. A., Mangino, M. J., Zhang, N., & Wen, X. (2016) · Scientific Reports · doi:10.1038/srep32888 · Cited by 81 · see citing works
Peng, L., Yoo, B., Gunewardena, S., Lu, H., Klaassen, C., & Zhong, X.-B. (2012) · Drug Metabolism And Disposition · doi:10.1124/dmd.112.045088 · Cited by 67 · see citing works
“This period is also the most rapidly growing stage of postnatal liver development, as studies have shown that cell proliferation in mouse liver is high until 20 days of age and then the hepatic architecture begins to resemble that of adult liver (Apte et al., 2007).”
BackgroundCSF1R-dependent macrophages control postnatal somatic growth and organ maturation
Keshvari, S., Caruso, M., Teakle, N., Batoon, L., Sehgal, A., Patkar, O. L., Ferrari-Cestari, M., Snell, C., Chen, C., Stevenson, A. J., et al. (2020) · bioRxiv · doi:10.1371/journal.pgen.1009605 · Cited by 64 · see citing works
“Conditional deletion of Ctnnb1 in hepatocytes of mice led to a 15–25% decrease in LBW ratio at postnatal day 30 [66].”
BackgroundMattis, A. N., Song, G., Hitchner, K., Kim, R. Y., Lee, A. Y., Sharma, A. D., Malato, Y., McManus, M. T., Esau, C., Koller, E., et al. (2014) · Hepatology · doi:10.1002/hep.27379 · Cited by 63 · see citing works
Targeting H19, an Imprinted Long Non-Coding RNA, in Hepatic Functions and Liver Diseases
Pope, C., Mishra, S., Russell, J. S., Zhou, Q.-Q., & Zhong, X.-B. (2017) · Diseases · doi:10.3390/diseases5010011 · Cited by 61 · see citing works
“The Wnt signaling pathway is critical for postnatal liver growth [49].”
BackgroundFigeac, F., Uzan, B., Faro, M., Chelali, N., Portha, B., & Movassat, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00538.2009 · Cited by 63 · see citing works
Yoshida, Y., Shimomura, T., Sakabe, T., Ishii, K., Gonda, K., Matsuoka, S., Watanabe, Y., Takubo, K., Tsuchiya, H., Hoshikawa, Y., et al. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00187.2007 · Cited by 52 · see citing works
“Additional reports have shown a requirement for Wnt signaling after liver cells are formed and not at the time of endoderm specification to form the liver (3, 43).”
BackgroundRestoration of Wnt/β-catenin signaling attenuates alcoholic liver disease progression in a rat model
Huang, C.-K., Yu, T., de la Monte, S. M., Wands, J., Derdák, Z., & Kim, M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.030 · Cited by 51
“In addition, loss of b-catenin expression in the liver delayed proliferation of hepatocytes in mice following partial hepatectomy [16,17].”
BackgroundMischke, M., Pruis, M. G. M., Boekschoten, M. V., Groen, A. K., Fitri, A. R., van de Heijning, B. J. M., Verkade, H. J., Müller, M. M., Plösch, T., & Steegenga, W. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078623 · Cited by 44 · see citing works
Septer, S., Edwards, G., Gunewardena, S., Wolfe, A., Li, H., Daniel, J., & Apte, U. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00056.2011 · Cited by 43 · see citing works
Self-citationProgranulin A-mediated MET Signaling Is Essential for Liver Morphogenesis in Zebrafish
Li, Y.-H., Chen, M. H., Gong, H., Hu, S., Li, Y., Lin, G.-H., Lin, C.-C., Liu, W., & Wu, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138743 · Cited by 35 · see citing works
Chaker, D., Mouawad, C., Azar, A., Quilliot, D., Achkar, I., Fajloun, Z., & Makdissy, N. (2018) · Stem cell research & therapeutics · doi:10.1186/s13287-018-0910-5 · Cited by 38 · see citing works
Platelets prime hematopoietic-vascular niche to drive angiocrine-mediated liver regeneration
Shido, K., Chavez, D., Cao, Z., Ko, J. L., Rafii, S., & Ding, B. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2016.44 · Cited by 36 · see citing works
“Both Vegfr1lysM/lysM and Cxcr7iΔ/iΔ mice exhibited suppressed expression of hepatocyte growth factor and Wnt2, two crucial trophogenic angiocrine factors instigating hepatocyte propagation.”
BackgroundInfluentialJin, Z., Han, Y.-X., & Han, X.-R. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.741753 · Cited by 36 · see citing works
Zhao, X., Monson, C., Gao, C., Gouon-Evans, V., Matsumoto, N., Sadler, K., & Friedman, S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.04.018 · Cited by 36 · see citing works
“Outgrowth is an important developmental process, since genes that regulate hepatic outgrowth are also critical for liver regeneration in adults (Apte et al., 2007; Sadler et al., 2007; Tan et al., 2006; Tan et al., 2008), indicating that the response to hepatic injury involves some of the signals that are essential fo…”
DRAM1 regulates the migration and invasion of hepatoblastoma cells via autophagy-EMT pathway
Chen, C., Liang, Q., Chen, H.-K., Wu, P.-F., Feng, Z.-Y., Ma, X.-M., Wu, H.-R., & Zhou, G.-Q. (2018) · Oncology Letters · doi:10.3892/ol.2018.8937 · Cited by 34 · see citing works
Tien, Y.-C., Liu, K., Pope, C., Wang, P., Ma, X., & Zhong, X.-B. (2015) · Drug Metabolism And Disposition · doi:10.1124/dmd.115.066316 · Cited by 34 · see citing works
Wnt signaling in gut organogenesis
Verzi, M., & Shivdasani, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5854 · Cited by 34 · see citing works
Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis
Kurosaki, S., Nakagawa, H., Hayata, Y., Kawamura, S., Matsushita, Y., Yamada, T., Uchino, K., Hayakawa, Y., Suzuki, N., Hata, M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100315 · Cited by 34 · see citing works
“Results Development of a persistent genetic labelling system for Zone 3 hepatocytes The activation ofWnt/b-catenin signalling in the liver is enhanced during postnatal days 5–20 and then gradually declines with age.(27) However, the spatial distribution of Wnt/b-catenin activation has not yet been explored.”
Backgroundβ-Catenin Activation in Hepatocellular Cancer: Implications in Biology and Therapy
Krutsenko, Y., Singhi, A. D., & Monga, S. P. (2021) · Cancers · doi:10.3390/cancers13081830 · Cited by 36 · see citing works
“It is also worth mentioning that, after birth, there is a postnatal growth spurt in livers from postnatal day 5 to about 25 days, after which the liver is mostly quiescent, showing minimal hepatocyte turnover [17].”
BackgroundSelf-citationGanzenberg, K., Singh, Y., & Braeuning, A. (2013) · Toxicology · doi:10.1016/j.tox.2013.03.019 · Cited by 29 · see citing works
Curcumin affects β‐catenin pathway in hepatic stellate cell in vitro and in vivo
Cui, L., Jia, X., Zhou, Q., Zhai, X.-G., Zhou, Y., & Zhu, H.-X. (2014) · The Journal of pharmacy and pharmacology · doi:10.1111/jphp.12283 · Cited by 27
Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade
Jin, Y., Anbarchian, T., Wu, P., Sarkar, A., Fish, M., Peng, W. C., & Nusse, R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203849119 · Cited by 26 · see citing works
Therapeutic Innovations for Targeting Hepatoblastoma.
Garnier, A., Ilmer, M., Kappler, R., & Berger, M. (2016) · Anticancer Research · doi:10.21873/anticanres.11143 · Cited by 26 · see citing works
Pathological implications of cadherin zonation in mouse liver
Hempel, M., Schmitz, A., Winkler, S., Kücükoglu, Ö., Brückner, S., Niessen, C. M., & Christ, B. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1861-y · Cited by 27 · see citing works
“In perivenous hepatocytes, Wnt/b-catenin signaling drives expression of the perivenous marker genes glutamine synthase, RNase 4 and Axin 2 amongst others; whereas in periportal hepatocytes, expression of periportal marker genes such as phosphoenolpyruvate carboxykinase (PCK1), Arginase 1 and carbamoylphosphate synthas…”
Faro, A., Boj, S., Ambrósio, R., van den Broek, O., Korving, J., & Clevers, H. (2009) · Zebrafish · doi:10.1089/zeb.2009.0580 · Cited by 25 · see citing works
Proteomic analysis of liver development of lean Pekin duck (Anas platyrhynchos domestica).
Zheng, A.-J., Liu, G.-H., Zhang, Y.-S., Hou, S., Chang, W.-H., Zhang, S., Cai, H.-Y., & Chen, G. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.06.019 · Cited by 24 · see citing works
Signalling pathways and transcriptional regulators orchestrating liver development and cancer
Campbell, S. A., Stephan, T. L., Lotto, J., Cullum, R., Drissler, S., & Hoodless, P. A. (2021) · Development · doi:10.1242/dev.199814 · Cited by 22 · see citing works
Prolactin regulates liver growth during postnatal development in mice.
Moreno-Carranza, B., Bravo-Manríquez, M., Báez, A., Ledesma-Colunga, M. G., Ruíz-Herrera, X., Reyes-Ortega, P., Ríos, E. A. D. L., Macotela, Y., de la Escalera, G. M., & Clapp, C. (2018) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00003.2018 · Cited by 22 · see citing works
“While some factors promoting postnatal liver growth have been deciphered (2, 26, 44), those restricting liver growth during the first 2 wk of life are basically unknown.”
BackgroundWheat Proteins Enhance Stability and Function of Adhesion Molecules in Cryopreserved Hepatocytes
Grondin, M., Hamel, F., Averill-Bates, D., & Sarhan, F. (2009) · Cell Transplantation · doi:10.3727/096368909788237104 · Cited by 20 · see citing works
Monga, S. P. (2020) · Liver · doi:10.1002/9781119436812.ch46 · Cited by 1 · see citing works
Self-citationIdentification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
Jam, F. A., Kadota, Y., Mendsaikhan, A., Tooyama, I., & Mori, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-21445-3 · Cited by 10 · see citing works
Lungova, V., Verheyden, J. M., Sun, X., & Thibeault, S. (2018) · Development · doi:10.1242/dev.157677 · Cited by 17 · see citing works
“…β-catenin signaling pathway plays a crucial role during development and adult stem cell maintenance of many organs (Stevens et al., 2003; Dessimoz et al., 2005; Apte et al., 2007), including lungs and trachea (Mucenski et al., 2003; Goss et al., 2009; Harris-Johnson et al., 2009; Woo et al., 2011).”
BackgroundThe role of H19, a long non-coding RNA, in mouse liver postnatal maturation
Pope, C., Piekos, S. C., Chen, L., Mishra, S., & Zhong, X.-B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187557 · Cited by 17 · see citing works
Models to Study Liver Regeneration
Pritchard, M. T., & Apte, U. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00002-6 · Cited by 26 · see citing works
Self-citationZhang, R., Kikuchi, A. T., Nakao, T., Russell, J. O., Preziosi, M. E., Poddar, M., Singh, S., Bell, A. W., England, S. G., & Monga, S. P. (2019) · Gene Expression · doi:10.3727/105221618x15373858350141 · Cited by 15 · see citing works
Self-citationNofal, A., AboShabaan, H. S., Fadda, W. A., Ereba, R. E., Elsharkawy, S., & Hathout, H. M. R. (2024) · Cells · doi:10.3390/cells13090732 · Cited by 14 · see citing works
“Changes in β -catenin activity are implicated in NAFLD pathogenesis [96–98].”
BackgroundWang, C.-J., Yang, D., & Luo, Y.-W. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2515 · Cited by 13
Anciuc-Crauciuc, M., Cucerea, M., Tripon, F., Crauciuc, G., & Bănescu, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010649 · Cited by 12 · see citing works
“When β -catenin is lost or when the Wnt inhibitor dikkopf1 is expressed in the lung epithelium following lung specification, it results in reduced development of the distal airway epithelium and an overall shift toward a more proximal lung development pattern [14,15].”
BackgroundMammalian target of rapamycin regulates expression of β-catenin in hepatocellular carcinoma.
Feng, Z.-B., Fan, X., Jiao, Y., & Ban, K. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.07.021 · Cited by 12 · see citing works
Negative impact of hyperglycaemia on mouse alveolar development
He, M.-Y., Wang, G., Han, S., Li, K., Jin, Y., Liu, M., Si, Z.-P., Ju, W., Liu, G., & Yang, X. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1403683 · Cited by 15 · see citing works
Kim, J., Kim, J., & Kwon, Y. H. (2016) · Nutrition Research and Practice · doi:10.4162/nrp.2016.10.4.386 · Cited by 11 · see citing works
“Because activation of beta-catenin activity during embryonic day 10 to 14 and PD 5 to 20 has been demonstrated [29], the time differences between the two studies might explain the catch-up growth of impaired liver by PD 21 as observed in the current study.”
ResultChoi, W., Kim, J., Ko, J. W., Choi, A., & Kwon, Y. H. (2022) · Amino Acids · doi:10.1007/s00726-022-03157-1 · Cited by 10
McGreal, S. R., Rumi, K., Soares, M. J., Woolbright, B. L., Jaeschke, H., & Apte, U. M. (2017) · International Journal of Toxicology · doi:10.1177/1091581817706067 · Cited by 12 · see citing works
Self-citationGroenendyk, J., & Michalak, M. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9265-3 · Cited by 10 · see citing works
“This correlates with Wnt/β-catenin signaling pathway up-regulated during hepatocyte proliferation in the liver [70, 71] and a hematopoietic cell regulator during embryogenesis [72], demonstrating the numerous cancers that result due to deregulated Wnt/β-catenin signaling, including hepatocarcinoma [73].”
BackgroundSá-Pereira, I., Roodselaar, J., Couch, Y., Sosthenes, M. C. K., Evans, M. C., Anthony, D., & Stolp, H. (2018) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2018.01.008 · Cited by 8 · see citing works
“In rodents, the liver undergoes an extensive structural remodelling during the first four weeks after birth (Alexander et al., 1997; Walthall et al., 2005), and the liver weight increases as a result of the hepatic cell proliferation (Apte et al., 2007; Behrens et al., 2002; Septer et al., 2012).”
Peng, L., Piekos, S. C., Guo, G. L., & Zhong, X.-B. (2017) · Nuclear Receptor Research · doi:10.11131/2017/101308 · Cited by 8 · see citing works
“Some groups have identified certain critical factors for postnatal liver development, including β-Catenin and Yesassociated protein [36, 37].”
BackgroundCui, H., Li, H., Li, Q.-L., Chen, J., Na, Q., & Liu, C.-X. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2958 · Cited by 8 · see citing works
Lu, S., Jiang, M. H., Chen, Q., Luo, X., Cao, Z., Huang, H., Zheng, M., & Du, J. (2022) · Pediatric Blood & Cancer · doi:10.1002/pbc.29705 · Cited by 7 · see citing works
Bento‐Bernardes, T., Toste, F. P., Pazos-Moura, C. C., & Oliveira, K. J. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8253 · Cited by 7 · see citing works
Ding, Q., Zhang, G., Wang, Y., Xu, L., Wu, M., Zhou, Y., Xu, T., Meng, X., Huang, C., & Zhang, L. (2022) · Redox Report · doi:10.1080/13510002.2022.2109360 · Cited by 8 · see citing works
“To further illustrate the potential function of HERC5, ISG15, and β-catenin in the progression of ALD, we induced liver injury in the AML-12 and L02 cells with EtOH in vitro.”
BackgroundInfluentialTranscriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing
Xu, J., Hao, S., Shi, Q., Deng, Q., Jiang, Y., Guo, P., Yuan, Y., Shi, X., Shangguan, S., Zheng, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.833392 · Cited by 6 · see citing works
Sewelam, A., & Mokhtar, H. E. L. (2019) · The Egyptian Journal of Histology · doi:10.21608/ejh.2019.11296.1108 · Cited by 5 · see citing works
“This finding was in agreement with some literature[51].”
ResultGulati, R., Hanlon, M., Lutz, M., Quitmeyer, T., Geller, J. I., Tiao, G. M., Timchenko, L., & Timchenko, N. (2022) · Cancers · doi:10.3390/cancers14246062 · Cited by 5 · see citing works
Hepatic Defenses Against Toxicity: Liver Regeneration and Tissue Repair
Apte, U. M., Bhushan, B., & Dadhania, V. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64918-8 · Cited by 2 · see citing works
Self-citationExpression profiling of adhesion proteins during prenatal and postnatal liver development in rats
Yousaf, M., Tayyeb, A., & Ali, G. (2017) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s139497 · Cited by 2 · see citing works
“They also indicated that β-catenin-knockout mouse shows reduced liver size at postnatal Day 30.(37) A general pattern that can be seen for most of the adhesion proteins, with few exceptions, is that they are expressed in high concentration in early liver development as well as in the postnatal stage.”
BackgroundMonga, S. P. S. (2010) · Springer eBooks · doi:10.1007/978-3-642-00150-5_25 · Cited by 3 · see citing works
Self-citationJin, Y., Anbarchian, T., Wu, P., Sarkar, A., Fish, M., & Nusse, R. (2021) · doi:10.1101/2021.10.15.464616 · Cited by 2 · see citing works
“The postnatal liver expands rapidly in a Wnt/βcatenin signaling-dependent way and switches from initially containing diploid hepatocytes to becoming mostly polyploid (Apte et al. 2007; Monga et al. 2001).”
BackgroundPrenatal Evaluations: A Prologue to Postnatal Pathology Interpretations
Elmore, S. (2021) · Toxicologic pathology (Print) · doi:10.1177/01926233211046540 · Cited by 2
“Liver mass increases by several fold in the first 3 weeks of postnatal life but declines in the fourth postnatal week when the liver:body weight ratio approaches adult levels.(37,38) Beginning around postnatal day 7, liver parenchymal cells (hepatocytes) begin to organize into well-defined hepatic plates.”
BackgroundEffectiveness of the liver micronucleus assay using juvenile mice
Nagasue, R., Murata, I., Sasaki, K., Sakai, R., Miyajima, H., & Shimoda, M. (2017) · Journal of Veterinary Medical Science · doi:10.1292/jvms.17-0116 · Cited by 2 · see citing works
“Several studies have shown that the hepatocyte proliferation in mice continues until the postnatal day (PND) 30 [2, 28].”
BackgroundMethodHematopoietic Stem Cells and Somatic Stem Cells
Tan, K. Y., Kim, F. S., Wagers, A. J., & Mayack, S. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-347-3_3 · Cited by 2 · see citing works
Low RT-based Genome Editing Fidelity in Mouse Hepatocytes: Challenges and SolutionsPreprint
Dunyak, M. T., Hanna, P., Nan, A. X., Stetina, J. R. V., Pokharel, R., O’Hara, M. S., Estes, B., Zheng, K., Svenson, S., Andresen, J., et al. (2024) · bioRxiv · doi:10.1101/2024.10.31.621282 · Cited by 1 · see citing works
“To test this hypothesis, we treated neonatal mice (Day 2 postnatal), as a significant number of hepatocytes are undergoing cell division during the first days of life [14].”
MethodHepatocellular and developmental influences of early postnatal indomethacin in mice
Nowrouzi, F., & Azadbakht, M. (2017) · Bratislava Medical Journal · doi:10.4149/bll_2017_009 · Cited by 1
“49 and Wnt/β-catenin signalling pathway plays an essential role in HGF-induced hepatocyte proliferation and biliary differentiation (15, 37, 23, 38, 34).”
InfluentialMolecular Basis of Liver Disease
Monga, S. P., & Behari, J. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374419-7.00020-2 · Cited by 1 · see citing works
Self-citationCieply, B. W. (2012) · doi:10.33915/etd.244
Self-citationChapter 1 – Development of the gastrointestinal tract
Montgomery, R. K., & Grand, R. (2006) · doi:10.1016/b978-0-7216-3924-6.50005-6 · Cited by 1
Effects of Hematopoietic Stem Cells on Liver Cirrhosis of Albino Rats
Hussein, N., & Raafat, M. M. M. N. (2019) · The Medical journal of Cairo University · doi:10.21608/mjcu.2019.54842
- Authors
- Apte, U., Zeng, G., Thompson, M. D., Muller, P., Micsenyi, A., Cieply, B., Kaestner, K. H., & Monga, S. P. S.
- Affiliations
- University of Pittsburgh (US)
- Venue
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Published
- 2007-06
- Volume
- 292
- Issue
- 6
- Pages
- G1578-G1585
- ISSN
- 0193-1857 (ISSN-L)
- 1522-1547
- OpenAlex
- W2144573829
- Cited by
- 119
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 9 · 2017: 11 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Gastrointestinal and Liver Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK062277)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- β-catenin, Wnt/β-catenin signaling, hepatocyte proliferation, liver development, glycogen synthase kinase-3β, casein kinase 2, liver-specific knockout mice
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Cell Membrane, Liver, Mice, Inbred ICR, RNA, Messenger, Time Factors, Signal Transduction, Cadherins, Mice, Knockout, Gene Expression Regulation, Developmental, Proliferating Cell Nuclear Antigen, Proto-Oncogene Proteins c-met, Hepatocytes, Glycogen Synthase Kinase 3, Casein Kinase II, Cell Proliferation, Wnt Proteins, beta Catenin, Mice, TCF Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
