WNT Signals Are Required for the Initiation of Hair Follicle Development

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works

Reiterative signaling and patterning during mammalian tooth morphogenesis

Jernvall, J., & Thesleff, I. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00322-6 · Cited by 1,101 · see citing works

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089 · see citing works

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

van Genderen, C., Okamura, R., Fariñas, I., Quo, R. G., Parslow, T., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 1,031 · see citing works

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works

Molecular Mechanisms Regulating Hair Follicle Development

Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967 · see citing works

The secret life of the hair follicle

Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931 · see citing works

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871 · see citing works

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772 · see citing works

Sonic hedgehog signaling is essential for hair development

St‐Jacques, B., Dassule, H. R., Karavanova, I. D., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70443-9 · Cited by 764 · see citing works

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works

Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

Mukhopadhyay, M., Shtrom, S., Rodrı́guez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 634 · see citing works

Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis

Chiang, C. C., Swan, R. Z., Grachtchouk, M. A., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9103 · Cited by 497 · see citing works

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis

Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489 · see citing works

Programming gene expression in developing epidermis

Byrne, C. R., Tainsky, M. A., & Fuchs, E. V. (1994) · Development · doi:10.1242/dev.120.9.2369 · Cited by 487 · see citing works

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint

Zhou, P., Byrne, C. R., Jacobs, J., & Fuchs, E. V. (1995) · Genes & Development · doi:10.1101/gad.9.6.700 · Cited by 474 · see citing works

Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- micePreprint

Galcerán, J., Fariñas, I., Depew, M. J., Clevers, H. C., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462 · see citing works

Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.Preprint

Kratochwil, K., Dull, M., Fariñas, I., Galcerán, J., & Grosschedl, R. (1996) · Genes & Development · doi:10.1101/gad.10.11.1382 · Cited by 425 · see citing works

Noggin is a mesenchymally derived stimulator of hair-follicle induction

Botchkarev, V. A., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J. A., Peters, C., Lauster, R., et al. (1999) · Nature Cell Biology · doi:10.1038/11078 · Cited by 414 · see citing works

Involvement of a novel Tnf receptor homologue in hair follicle induction.

Headon, D. J., & Overbeek, P. A. (1999) · Nature Genetics · doi:10.1038/11943 · Cited by 379 · see citing works

Local Inhibitory Action of BMPs and Their Relationships with Activators in Feather Formation: Implications for Periodic Patterning

Jung, H.-S., Francis‐West, P. H., Widelitz, R. B., Jiang, T., Ting‐Berreth, S. A., Tickle, C. A., Wolpert, L., & Chuong, C. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8850 · Cited by 379 · see citing works

Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development

McGowan, K. M., & Coulombe, P. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.469 · Cited by 319 · see citing works

Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

Yan, M., Wang, L.-C., Hymowitz, S. G., Schilbach, S., Lee, J., Goddard, A. D., de Vos, A. M., Gao, W., & Dixit, V. M. (2000) · Science · doi:10.1126/science.290.5491.523 · Cited by 312 · see citing works

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

Srivastava, A. K., Pispa, J., Hartung, A. J., Du, Y., Ezer, S., Jenks, T., Shimada, T., Pekkanen, M., Mikkola, M. L., Ko, M. S. H., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13069 · Cited by 301 · see citing works

WNT Signaling in the Control of Hair Growth and Structure

Millar, S. E., Willert, K., Salinas, P. C., Roelink, H., Nusse, R., Sussman, D. J., & Barsh, G. S. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9140 · Cited by 292 · see citing works

Expression of Wnt signalling pathway genes during tooth development

Sarkar, L., & Sharpe, P. T. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00095-7 · Cited by 248 · see citing works

β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

Zhu, A. J., & Watt, F. M. (1999) · Development · doi:10.1242/dev.126.10.2285 · Cited by 240 · see citing works

Wnt signalling: Antagonistic Dickkopfs

Zorn, A. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00360-8 · Cited by 238 · see citing works

Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia

Jiang, T., Jung, H.-S., Widelitz, R. B., & Chuong, C. (1999) · Development · doi:10.1242/dev.126.22.4997 · Cited by 237 · see citing works

BMPs mediate lateral inhibition at successive stages in feather tract development

Noramly, S., & Morgan, B. A. (1998) · Development · doi:10.1242/dev.125.19.3775 · Cited by 208 · see citing works

Dickkopf genes are co-ordinately expressed in mesodermal lineages

Monaghan, A. P., Kioschis, P., Wu, W., Zúñiga, A., Bock, D., Poustka, A., Delius, H., & Niehrs, C. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00138-0 · Cited by 192 · see citing works

β-catenin signaling can initiate feather bud development

Noramly, S., Freeman, A., & Morgan, B. A. (1999) · Development · doi:10.1242/dev.126.16.3509 · Cited by 192 · see citing works

Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor

Saitou, M., Sugai, S., Tanaka, T., Shimouchi, K., Fuchs, E. V., Narumiya, S., & Kakizuka, A. (1995) · Nature · doi:10.1038/374159a0 · Cited by 171 · see citing works

Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain

Ferguson, B. M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.9.1589 · Cited by 168 · see citing works

β-catenin in Epithelial Morphogenesis: Conversion of Part of Avian Foot Scales into Feather Buds with a Mutated β-Catenin

Widelitz, R. B., Jiang, T., Lu, J., & Chuong, C. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9580 · Cited by 162 · see citing works

Transgenic studies with a keratin promoter-driven growth hormone transgene: Prospects for gene therapy

Wang, X., Zinkel, S. S., Polonsky, K. S., & Fuchs, E. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.219 · Cited by 160 · see citing works

Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development

Christiansen, J. H., Dennis, C. L., Wicking, C., Monkley, S. J., Wilkinson, D. G., & Wainwright, B. J. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00383-5 · Cited by 134 · see citing works

TROY, a Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily, Exhibits a Homology with Edar and Is Expressed in Embryonic Skin and Hair Follicles

Kojima, T., Morikawa, Y., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Senba, E., & Kitamura, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002691200 · Cited by 133 · see citing works

Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults.

Wang, J., & Shackleford, G. M. (1996) · PubMed · Cited by 97 · see citing works

Prenatal formation of hair follicle types,

Mann, S. J. (1962) · The Anatomical Record · doi:10.1002/ar.1091440208 · Cited by 95 · see citing works

Wnt signaling: An embarrassment of receptors

Bejsovec, A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00852-6 · Cited by 77 · see citing works

Dorsal dermis development depends on a signal from the dorsal neural tube, which can be substituted by Wnt-1

Olivera-Martínez, I., Thélu, J., Teillet, M., & Dhouailly, D. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00540-2 · Cited by 77 · see citing works

Wandering epithelial cells in the rabbit embryo milk line

Propper, A. Y. (1978) · Developmental Biology · doi:10.1016/0012-1606(78)90311-1 · Cited by 66 · see citing works

Sequence of cDNA for murineZfy-1, a candidate forTdy

Ashworth, A., Swift, S., & Affara, N. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.7.2864 · Cited by 46 · see citing works

Changing Patterns of Cell Adhesion Molecules during Mouse Pelage Hair Follicle Development

Vielkind, U., & Hardy, M. H. (1996) · Cells Tissues Organs · doi:10.1159/000147880 · Cited by 43 · see citing works

Solving a sticky problem

Niehrs, C. (2001) · Nature · doi:10.1038/35101682 · Cited by 37 · see citing works

Inference and analysis of cell-cell communication using CellChat

Jin, S., Guerrero-Juarez, C. F., Zhang, L., Chang, I., Ramos, R., Kuan, C.-H., Myung, P., Plikus, M. V., & Nie, Q. (2021) · Nature Communications · doi:10.1038/s41467-021-21246-9 · Cited by 8,409 · see citing works

Wnt/β-catenin signaling and disease

Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554 · see citing works

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342 · see citing works

Defining the Epithelial Stem Cell Niche in Skin

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031 · see citing works

Epidermal homeostasis: a balancing act of stem cells in the skin

Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270 · see citing works

The Hair Follicle as a Dynamic Miniorgan

Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119 · see citing works

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Pinto, D., Gregorieff, A., Begthel, H., & Clevers, H. (2003) · Genes & Development · doi:10.1101/gad.267103 · Cited by 1,026 · see citing works

Function and biological roles of the Dickkopf family of Wnt modulators

Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works

Scratching the surface of skin development

Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930 · see citing works

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Asselin-Labat, M.-L., Sutherland, K. D., Barker, H., Thomas, R., Shackleton, M., Forrest, N. C., Hartley, L., Robb, L., Grosveld, F. G., van der Wees, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1530 · Cited by 840 · see citing works

Epidermal Stem Cells of the Skin

Blanpain, C., & Fuchs, E. V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 845 · see citing works

Wnt signaling in development and tissue homeostasis

Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821 · see citing works

HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing

Zhang, B., Wang, M., Gong, A.-H., Zhang, X., Wu, X., Zhu, Y.-H., Shi, H., Wu, L.-J., Zhu, W., Qian, H., et al. (2015) · Stem Cells · doi:10.1002/stem.1771 · Cited by 746 · see citing works

Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer

Lammi, L., Arte, S., Somer, M., Järvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., & Nieminen, P. (2004) · The American Journal of Human Genetics · doi:10.1086/386293 · Cited by 689 · see citing works

Characterization and isolation of stem cell-enriched human hair follicle bulge cells

Ohyama, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26043 · Cited by 616 · see citing works

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism

Sick, S., Reinker, S., Timmer, J., & Schlake, T. (2006) · Science · doi:10.1126/science.1130088 · Cited by 612 · see citing works

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., METZGER, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W., et al. (2008) · Nature · doi:10.1038/nature06835 · Cited by 597 · see citing works

Epithelial Stem Cells: Turning over New Leaves

Blanpain, C., Horsley, V., & Fuchs, E. V. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 593 · see citing works

Therapeutic implications of cancer stem cells

Al‐Hajj, M., Becker, M. W., Wicha, M. S., Weissman, I. L., & Clarke, M. F. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.007 · Cited by 561 · see citing works

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in micePreprint

Grigoryan, T., Wend, P., Klaus‐Bergmann, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 558 · see citing works

Skin shedding and tissue regeneration in African spiny mice (Acomys)

Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., & Maden, M. (2012) · Nature · doi:10.1038/nature11499 · Cited by 556 · see citing works

Molecular principles of hair follicle induction and morphogenesis

Schmidt‐Ullrich, R., & Paus, R. (2005) · BioEssays · doi:10.1002/bies.20184 · Cited by 549 · see citing works

Androgenetic alopecia: a review

Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., & Lombardo, F. P. (2017) · Endocrine · doi:10.1007/s12020-017-1280-y · Cited by 539 · see citing works

Stem cells of the skin epithelium

Alonso, L. C., & Fuchs, E. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1734203100 · Cited by 521 · see citing works

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

Li, Y., Welm, B. E., Podsypanina, K., Huang, S., Chamorro, M. N., Zhang, X., Rowlands, T. M., Egeblad, M., Cowin, P., Werb, Z., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136825100 · Cited by 520 · see citing works

Mechanisms of ectodermal organogenesis.

Pispa, J., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00325-7 · Cited by 499 · see citing works

Physiological factors that regulate skin pigmentation

Yamaguchi, Y., & Hearing, V. J. (2009) · BioFactors · doi:10.1002/biof.29 · Cited by 495 · see citing works

Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society

Escobar-Morreale, H. F., Carmina, E., Dewailly, D., Gambineri, A., Kelestimur, F., Moghetti, P., Pugeat, M., Qiao, J., Wijeyaratne, C. N., Witchel, S. F., et al. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr042 · Cited by 494 · see citing works

Cutaneous wound healing: recruiting developmental pathways for regeneration

Bielefeld, K. A., Amini‐Nik, S., & Alman, B. A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1152-9 · Cited by 482 · see citing works

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

Goss, A., Tian, Y., Tsukiyama, T., Cohen, E. D., Zhou, D. D., Lu, M. M., Yamaguchi, T. P., & Morrisey, E. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.005 · Cited by 447 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

Skin stem cells: rising to the surface

Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708185 · Cited by 431 · see citing works

Hedgehog beyond medulloblastoma and basal cell carcinoma

Teglund, S., & Toftgård, R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.01.003 · Cited by 426 · see citing works

Review of hair follicle dermal cells

Yang, C.-C., & Cotsarelis, G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.11.005 · Cited by 418 · see citing works

β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

Enshell‐Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.016 · Cited by 408 · see citing works

Stem cell dynamics, migration and plasticity during wound healing

Dekoninck, S., & Blanpain, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0237-6 · Cited by 402 · see citing works

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008) · Cell · doi:10.1016/j.cell.2007.11.047 · Cited by 424 · see citing works

Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth

Higgins, C. A., Chen, J. C., Cerise, J. E., Jahoda, C. A. B., & Christiano, A. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309970110 · Cited by 396 · see citing works

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A., Millar, S. E., & Epstein, J. A. (2005) · Nature · doi:10.1038/nature03292 · Cited by 397 · see citing works

Signaling Involved in Hair Follicle Morphogenesis and Development

Pisal, R. V., Dev, K., Diaz, D. C., Qureshi, W. M. S., Filip, S., & Mokrý, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 391 · see citing works

Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling

Sennett, R., & Rendl, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 387 · see citing works

Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis

Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S. H., Lu, M., Piccolo, S., Schmidt‐Ullrich, R., et al. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.016 · Cited by 381 · see citing works

EpithelialBmpr1aregulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

Andl, T., Ahn, K. J., Kairo, A., Chu, E. Y., Lee, L. W., Reddy, S. T., Croft, N. J., Cebra‐Thomas, J. A., METZGER, D., Chambon, P., et al. (2004) · Development · doi:10.1242/dev.01125 · Cited by 380 · see citing works

Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling

Järvinen, E., Salazar‐Ciudad, I., Birchmeier, W., Taketo, M. M., Jernvall, J., & Thesleff, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607289103 · Cited by 379 · see citing works

A Wnt Survival Guide: From Flies to Human Disease

Chien, A. J., Conrad, W. H., & Moon, R. T. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.445 · Cited by 377 · see citing works

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging

Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., & Gutkind, J. S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.017 · Cited by 371 · see citing works

Wnt10b Inhibits Development of White and Brown Adipose Tissues

Longo, K. A., Hahn, W. S., Kang, S., Gerin, I., Chiang, S.-H., Lucas, P. C., Opp, M. R., & MacDougald, O. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402937200 · Cited by 372 · see citing works

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.011 · Cited by 363 · see citing works

Cadherins and catenins in breast cancer

Cowin, P., Rowlands, T. M., & Hatsell, S. J. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.014 · Cited by 362 · see citing works

The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359 · see citing works

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

Haegebarth, A., & Clevers, H. C. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080758 · Cited by 360 · see citing works

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336 · see citing works

Contribution of stem cells and differentiated cells to epidermal tumours

Owens, D. M., & Watt, F. M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1096 · Cited by 346 · see citing works

The stem cell niche: theme and variations

Ohlstein, B., Kai, T., Decotto, E., & Spradling, A. C. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.003 · Cited by 341 · see citing works

Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

Cadieu, É., Neff, M. W., Quignon, P., Walsh, K. F., Chase, K., Parker, H. G., vonHoldt, B. M., Rhue, A., Boyko, A. R., Byers, A., et al. (2009) · Science · doi:10.1126/science.1177808 · Cited by 341 · see citing works

Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

Celso, C. L., Prowse, D. M., & Watt, F. M. (2004) · Development · doi:10.1242/dev.01052 · Cited by 339 · see citing works

Stem cells in the skin: waste not, Wnt notPreprint

Alonso, L. C., & Fuchs, E. V. (2003) · Genes & Development · doi:10.1101/gad.1086903 · Cited by 336 · see citing works

Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis

Choi, Y. S., Zhang, Y., Xu, M., Yang, Y., Ito, M., Peng, T., Cui, Z., Nagy, A., Hadjantonakis, A., Lang, R. A., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.003 · Cited by 332 · see citing works

γ-Secretase Functions through Notch Signaling to Maintain Skin Appendages but Is Not Required for Their Patterning or Initial Morphogenesis

Pan, Y., Lin, M., Tian, X., Cheng, H., Gridley, T., Shen, J., & Kopan, R. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.014 · Cited by 326 · see citing works

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

Rabbani, P. S., Takeo, M., Chou, W. C., Myung, P. S., Bosenberg, M., Chin, L., Taketo, M. M., & Ito, M. (2011) · Cell · doi:10.1016/j.cell.2011.05.004 · Cited by 322 · see citing works

Making a tooth: growth factors, transcription factors, and stem cells

ZHANG, Y. D., Chen, Z., Yi Qiang, S. O. N. G., Liu, C., & Chen, Y. P. (2005) · Cell Research · doi:10.1038/sj.cr.7290299 · Cited by 309 · see citing works

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling

Kobielak, K., Stokes, N., Cruz-Racelis, J. D., Polak, L., & Fuchs, E. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703004104 · Cited by 308 · see citing works

Mitotic and mitogenic Wnt signalling

Niehrs, C., & Acebron, S. P. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.124 · Cited by 305 · see citing works

Manifestations and mechanisms of stem cell aging

Liu, L. A., & Rando, T. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010131 · Cited by 306 · see citing works

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Chu, E. Y., Hens, J. R., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A. B., Wysolmerski, J. J., & Millar, S. E. (2004) · Development · doi:10.1242/dev.01347 · Cited by 299 · see citing works

Wnt/β-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal–distal patterning in the lung

Shu, W., Guttentag, S. H., Wang, Z., Andl, T., Ballard, P. L., Lu, M. M., Piccolo, S., Birchmeier, W., Whitsett, J. A., Millar, S. E., et al. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.04.014 · Cited by 298 · see citing works

Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

Yaghoubi, Y., Movassaghpour, A. A., Zamani, M., Talebi, M., Mehdizadeh, A., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116733 · Cited by 296 · see citing works

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

Liu, B. Y., McDermott, S., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 293 · see citing works

Genetic basis of tooth agenesis

Nieminen, P. (2009) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21277 · Cited by 283 · see citing works

Keratins of the Human Hair Follicle

Langbein, L., & Schweizer, J. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)43001-6 · Cited by 282 · see citing works

Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

Kwack, M. H., Sung, Y. K., Chung, E. J., Im, S. U., Ahn, J. S., Kim, M. K., & Kim, J. C. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700999 · Cited by 277 · see citing works

WNT signaling in glioblastoma and therapeutic opportunities

Lee, Y., Lee, J., Ahn, S. H., Lee, J., & Nam, D. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.140 · Cited by 272 · see citing works

On mammary stem cells

Woodward, W. A., Chen, M. S., Behbod, F., & Rosen, J. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02532 · Cited by 274 · see citing works

Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities

Piao, H., Yan, R., Zhang, X., Wang, L., Ke, X., & Qu, Y. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.008 · Cited by 269 · see citing works

FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1 −/− micePreprint

Kratochwil, K., Galcerán, J., Tontsch, S., Roth, W., & Grosschedl, R. (2002) · Genes & Development · doi:10.1101/gad.1035602 · Cited by 270 · see citing works

Wnt Signaling in Skin Development, Homeostasis, and Disease

Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268 · see citing works

Molecular and cellular mechanisms of tooth development, homeostasis and repair

Yu, T., & Klein, O. D. (2020) · Development · doi:10.1242/dev.184754 · Cited by 270 · see citing works

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

Laurikkala, J., Mikkola, M. L., James, M. J., Tümmers, M., Mills, A. A., & Thesleff, I. (2006) · Development · doi:10.1242/dev.02325 · Cited by 265 · see citing works

Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice

Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003) · Genes & Development · doi:10.1101/gad.1076103 · Cited by 263 · see citing works

Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell LineagesPreprint

Jussila, M., & Thesleff, I. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008425 · Cited by 263 · see citing works

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA

Kobielak, K., Pasolli, H. A., Alonso, L. C., Polak, L., & Fuchs, E. V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200309042 · Cited by 261 · see citing works

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260 · see citing works

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

Scharschmidt, T. C., Vasquez, K. S., Pauli, M. L., Leitner, E. G., Chu, K., Truong, H.-A., Lowe, M. M., Sanchez Rodriguez, R., Ali, N., Laszik, Z. G., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.001 · Cited by 258 · see citing works

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi, B. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144915 · Cited by 263 · see citing works

Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis

Estrach, S., Ambler, C. A., Celso, C. L., Hozumi, K., & Watt, F. M. (2006) · Development · doi:10.1242/dev.02644 · Cited by 254 · see citing works

Stimulation of ectodermal organ development by Ectodysplasin-A1

Mustonen, T., Pispa, J., Mikkola, M. L., Pummila, M., Kangas, A. T., Pakkasjärvi, L., Jaatinen, R., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00157-x · Cited by 253 · see citing works

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

Le, P. N., McDermott, J. D., & Jimeno, A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.08.005 · Cited by 253 · see citing works

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signalingPreprint

Lien, W., & Fuchs, E. V. (2014) · Genes & Development · doi:10.1101/gad.244772.114 · Cited by 252 · see citing works

Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: The odonto-onycho-dermal dysplasia

Adaimy, L., Chouery, E., Mégarbané, H., Mroueh, S., Delague, V., Nicolas, E., Belguith, H., de Mazancourt, P., & Mégarbané, A. (2007) · The American Journal of Human Genetics · doi:10.1086/520064 · Cited by 248 · see citing works

Wnt Proteins in Mammary Development and Cancer

Brennan, K. R., & Brown, A. M. C. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037157.94207.33 · Cited by 245 · see citing works

Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development

Chen, J., Lan, Y., Baek, J.-A., Gao, Y., & Jiang, R. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.07.015 · Cited by 242 · see citing works

Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

Myung, P. S., Takeo, M., Ito, M., & Atit, R. P. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.230 · Cited by 242 · see citing works

The importance of signal pathway modulation in all aspects of tooth development

Tümmers, M., & Thesleff, I. (2009) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21280 · Cited by 241 · see citing works

Wnt signaling in stem and cancer stem cells

Wend, P., Holland, J. D., Ziebold, U., & Birchmeier, W. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.09.004 · Cited by 236 · see citing works

Mesenchymal–epithelial interactions in the skin

Yamaguchi, Y., Itami, S., Watabe, H., Yasumoto, K., ABDEL‐MALEK, Z. A., Kubo, T., Rouzaud, F., Tanemura, A., Yoshikawa, K., & Hearing, V. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311122 · Cited by 232 · see citing works

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

van Amerongen, R., Fuerer, C., Mizutani, M., & Nusse, R. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.020 · Cited by 224 · see citing works

Man's Best Friend Becomes Biology's Best in Show: Genome Analyses in the Domestic Dog

Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-115200 · Cited by 220 · see citing works

Ectodysplasin signaling in development.

Mikkola, M. L., & Thesleff, I. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00020-0 · Cited by 217 · see citing works

Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Wang, S., Drummond, M. L., Guerrero-Juarez, C. F., Tarapore, E., MacLean, A. L., Stabell, A. R., Wu, S. C., Gutierrez, G., That, B. T., Benavente, C. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18075-7 · Cited by 218 · see citing works

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Chu, E. Y., Hens, J. R., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A. B., Wysolmerski, J. J., & Millar, S. E. (2004) · Development · doi:10.1242/dev.01347 · Cited by 299 · see citing works

0928 Dkk4 fine-tunes Wnt activity for hair follicle patterning and initiation

Teshima, H., Khatif, H., & Bazzi, H. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.06.959

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260 · see citing works

Epidermal Wnt Controls Hair Follicle Induction by Orchestrating Dynamic Signaling Crosstalk between the Epidermis and Dermis

Fu, J., & Hsu, W. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.407 · Cited by 120 · see citing works

Early stages of hair follicle development: a step by step microarray identity.

Cadau, S., Rosignoli, C., Rhetore, S., Voegel, J., Parenteau‐Bareil, R., & Berthod, F. (2013) · PubMed · doi:10.1684/ejd.2013.1972 · Cited by 17 · see citing works