The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression
Open accessAbstract
We show that combinatorial mouse alleles for the secreted metalloproteases Adamts5, Adamts20 (bt), and Adamts9 result in fully penetrant soft-tissue syndactyly. Interdigital webs in Adamts5−/−; bt/bt mice had reduced apoptosis and decreased cleavage of the proteoglycan versican; however, the BMP-FGF axis, which regulates interdigital apoptosis was unaffected. BMP4 induced apoptosis, but without concomitant versican proteolysis. Haploinsufficiency of either Vcan or Fbln1, a co-factor for versican processing by ADAMTS5, led to highly penetrant syndactyly in bt mice, suggesting that cleaved versican was essential for web regression. The local application of an amino-terminal versican fragment corresponding to ADAMTS-processed versican, induced cell death in Adamts5−/−; bt/bt webs. Thus, ADAMTS proteases cooperatively maintain versican proteolysis above a required threshold to create a permissive environment for apoptosis. The data highlight the developmental significance of proteolytic action on the ECM, not only as a clearance mechanism, but also as a means to generate bioactive versican fragments.
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Cites
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
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Extracellular Matrix Degradation and Remodeling in Development and Disease
Lu, P., Takai, K., Weaver, V. M., & Werb, Z. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005058 · Cited by 2,265
Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression
Brassart-Pasco, S., Brézillon, S., Brassart, B., Ramont, L., Oudart, J.-B., & Monboisse, J. C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00397 · Cited by 335
A human embryonic limb cell atlas resolved in space and time
Zhang, B., He, P., Lawrence, J. E. G., Wang, S., Tuck, E., Williams, B. A., Roberts, K., Kleshchevnikov, V., Mamanova, L., Bolt, L., et al. (2024) · Nature · doi:10.1038/s41586-023-06806-x · Cited by 143
Nandadasa, S., Kraft, C. M., Wang, L. W., O’Donnell, A., Patel, R., Gee, H. Y., Grobe, K., Cox, T. C., Hildebrandt, F., & Apte, S. S. (2019) · Nature Communications · doi:10.1038/s41467-019-08520-7 · Cited by 76
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Metadata
- Authors
- McCulloch, D. R., Nelson, C. M., Dixon, L. J., Silver, D. L., Wylie, J. D., Lindner, V., Sasaki, T., Cooley, M. A., Argraves, W. S., & Apte, S. S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 17
- Issue
- 5
- Pages
- 687-698
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1994823840
- Cited by
- 254
- References
- 51
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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