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Cited by 254

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression

Open access
McCulloch, Daniel R., Nelson, Courtney M., Dixon, Laura J., Silver, Debra L., Wylie, James D., Lindner, Volkhard, Sasaki, Takako, Cooley, Marion A., Argraves, W. Scott, Apte, Suneel S.·2009·Developmental Cell
DOI 10.1016/j.devcel.2009.09.008
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Abstract

We show that combinatorial mouse alleles for the secreted metalloproteases Adamts5, Adamts20 (bt), and Adamts9 result in fully penetrant soft-tissue syndactyly. Interdigital webs in Adamts5−/−; bt/bt mice had reduced apoptosis and decreased cleavage of the proteoglycan versican; however, the BMP-FGF axis, which regulates interdigital apoptosis was unaffected. BMP4 induced apoptosis, but without concomitant versican proteolysis. Haploinsufficiency of either Vcan or Fbln1, a co-factor for versican processing by ADAMTS5, led to highly penetrant syndactyly in bt mice, suggesting that cleaved versican was essential for web regression. The local application of an amino-terminal versican fragment corresponding to ADAMTS-processed versican, induced cell death in Adamts5−/−; bt/bt webs. Thus, ADAMTS proteases cooperatively maintain versican proteolysis above a required threshold to create a permissive environment for apoptosis. The data highlight the developmental significance of proteolytic action on the ECM, not only as a clearance mechanism, but also as a means to generate bioactive versican fragments.

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Metadata

Authors
McCulloch, D. R., Nelson, C. M., Dixon, L. J., Silver, D. L., Wylie, J. D., Lindner, V., Sasaki, T., Cooley, M. A., Argraves, W. S., & Apte, S. S.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2009-11
Volume
17
Issue
5
Pages
687-698
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2009.09.008
OpenAlex
W1994823840
Cited by
254
References
51
FWCI
5.84
Type
journal article
Language
en
Open access
bronze

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