The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Versican V1 Proteolysis in Human Aorta in Vivo Occurs at the Glu441-Ala442 Bond, a Site That Is Cleaved by Recombinant ADAMTS-1 and ADAMTS-4
Open accessAbstract
Mature human aorta contains a 70-kDa versican fragment, which reacts with a neoepitope antiserum to the C-terminal peptide sequence DPEAAE. This protein therefore appears to represent the G1 domain of versican V1 (G1-DPEAAE(441)), which has been generated in vivo by proteolytic cleavage at the Glu(441)-Ala(442) bond, within the sequence DPEAAE(441)-A(442)RRGQ. Because the equivalent aggrecan product (G1-NITEGE(341)) and brevican product (G1-EAVESE(395)) are generated by ADAMTS-mediated cleavage of the respective proteoglycans, we tested the capacity of recombinant ADAMTS-1 and ADAMTS-4 to cleave versican at Glu(441)-Ala(442). Both enzymes cleaved a recombinant versican substrate and native human versican at the Glu(441)-Ala(442) bond and the mature form of ADAMTS-4 was detected by Western analysis of extracts of aortic intima. We conclude that versican V1 proteolysis in vivo can be catalyzed by one or more members of the ADAMTS family of metalloproteinases.
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Matsui, F., Nishizuka, M., Yasuda, Y., Aono, S., Watanabe, E., & Oohira, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00009-2 · Cited by 78
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PORTER, S., CLARK, I. M., KEVORKIAN, L., & EDWARDS, D. R. (2005) · Biochemical Journal · doi:10.1042/bj20040424 · Cited by 779
Extracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465
Self-citationFisher, D., Xing, B., Dill, J., Li, H., Hoang, H. H., Zhao, Z., Yang, X.-L., Bachoo, R., Cannon, S., Longo, F. M., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1737-11.2011 · Cited by 312
Kolodgie, F. D., Burke, A. P., Farb, A., Weber, D. K., Kutys, R., Wight, T. N., & Virmani, R. (2002) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000034021.92658.4c · Cited by 286
Self-citationVersican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Wight, T. N., Kang, I., Evanko, S. P., Harten, I. A., Chang, M. Y., Pearce, O. M. T., Allen, C. E., & Frevert, C. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00512 · Cited by 268
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Metadata
- Authors
- Sandy, J. D., Westling, J., Kenagy, R. D., Iruela-Arispe, M. L., Verscharen, C., Rodriguez-Mazaneque, J. C., Zimmermann, D. R., Lemire, J. M., Fischer, J. W., Wight, T. N., & Clowes, A. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 16
- Pages
- 13372-13378
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2121535505
- Cited by
- 453
- References
- 1
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sandy, J. D., Westling, J., Kenagy, R. D., Iruela-Arispe, M. L., Verscharen, C., Rodriguez-Mazaneque, J. C., Zimmermann, D. R., Lemire, J. M., Fischer, J. W., Wight, T. N., & Clowes, A. W. (2001). Versican V1 Proteolysis in Human Aorta in Vivo Occurs at the Glu441-Ala442 Bond, a Site That Is Cleaved by Recombinant ADAMTS-1 and ADAMTS-4. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m009737200
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