The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter
Open accessAbstract
SUMMARY The roles of inflammatory cytokines and the immune response in cancer remain paradoxical. In the case of tumor necrosis factor (TNF), there is undisputed evidence indicating both protumor and antitumor activities. Recent work in Drosophila indicated that a TNF-dependent mechanism eliminates cells deficient for the polarity tumor suppressors dlg or scrib. In this study, however, we show that in tumors deficient for scrib that also expressed the Ras oncoprotein, the TNF signal was diverted into a protumor signal that enhanced tumor growth through larval arrest and stimulated invasive migration. In this case, TNF promoted malignancy and was detrimental to host survival. TNF was expressed at high levels by tumor-associated hemocytes recruited from the circulation. The expression of TNF by hemocytes was both necessary and sufficient to trigger TNF signaling in tumor cells. Our evidence suggests that tumors can evolve into malignancy through oncogenic Ras activation and the hijacking of TNF signaling.
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Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine · doi:10.1038/10552 · Cited by 839
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · cited 1×
“Although the importance of Ras in cancer is widely appreciated, the role of mammalian scribble group genes as tumor suppressors is just beginning to emerge (Humbert et al., 2008; Zhan et al., 2008).”
BackgroundIgaki, T., Pastor-Pareja, J. C., Aonuma, H., Miura, M., & Xu, T. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.002 · Cited by 295
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Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Inflammation meets cancer, with NF-κB as the matchmaker
Ben-Neriah, Y., & Karin, M. (2011) · Nature Immunology · doi:10.1038/ni.2060 · Cited by 1,373
Cancer-related inflammation: Common themes and therapeutic opportunities
Balkwill, F. R., & Mantovani, A. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.005 · Cited by 685
Microenvironmental autophagy promotes tumour growth
Katheder, N. S., Khezri, R., O’Farrell, F., Schultz, S. W., Jain, A., Rahman, M. M., Schink, K. O., Theodossiou, T. A., Johansen, T., Juhász, G., et al. (2017) · Nature · doi:10.1038/nature20815 · Cited by 459
The chemokine MCP-1 (CCL2) in the host interaction with cancer: a foe or ally?
Yoshimura, T. (2018) · Cellular & Molecular Immunology · doi:10.1038/cmi.2017.135 · Cited by 266
Metadata
- Authors
- Cordero, J. B., Macagno, J. P., Stefanatos, R. K., Strathdee, K. E., Cagan, R. L., & Vidal, M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 18
- Issue
- 6
- Pages
- 999-1011
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1996137175
- Cited by
- 239
- References
- 4
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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