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Collective Chemotaxis Requires Contact-Dependent Cell Polarity
Open accessAbstract
Directional collective migration is now a widely recognized mode of migration during embryogenesis and cancer. However, how a cluster of cells responds to chemoattractants is not fully understood. Neural crest cells are among the most motile cells in the embryo, and their behavior has been likened to malignant invasion. Here, we show that neural crest cells are collectively attracted toward the chemokine Sdf1. While not involved in initially polarizing cells, Sdf1 directionally stabilizes cell protrusions promoted by cell contact. At this cell contact, N-cadherin inhibits protrusion and Rac1 activity and in turn promotes protrusions and activation of Rac1 at the free edge. These results show a role for N-cadherin during contact inhibition of locomotion, and they reveal a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis, whereby attractants such as Sdf1 amplify and stabilize contact-dependent cell polarity, resulting in directional collective migration.
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Cited by
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Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721
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Simões-Costa, M., & Bronner, M. E. (2015) · Development · doi:10.1242/dev.105445 · Cited by 649
Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration
Carmona-Fontaine, C., Theveneau, E., Tzekou, A., Tada, M., Woods, M., Page, K. M., Parsons, M., Lambris, J. D., & Mayor, R. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.10.012 · Cited by 317
Self-citationThe extracellular matrix dimension of skeletal muscle development
Thorsteinsdóttir, S., Deries, M., Cachaço, A. S., & Bajanca, F. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.03.015 · Cited by 167
Dubon, M. J., Yu, J., Choi, S., & Park, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25863 · Cited by 76
Metadata
- Authors
- Theveneau, E., Marchant, L., Kuriyama, S., Gull, M., Moepps, B., Parsons, M., & Mayor, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 19
- Issue
- 1
- Pages
- 39-53
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1974640915
- Cited by
- 536
- References
- 0
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Theveneau, E., Marchant, L., Kuriyama, S., Gull, M., Moepps, B., Parsons, M., & Mayor, R. (2010). Collective Chemotaxis Requires Contact-Dependent Cell Polarity. Developmental Cell. https://doi.org/10.1016/j.devcel.2010.06.012
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