The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells
Open accessAbstract
Summary The switch from mitosis to meiosis is a unique feature of germ cell development. In mammals, meiotic initiation requires retinoic acid (RA), which activates meiotic inducers including Stra8, but how the switch to meiosis is controlled in male germ cells (spermatogonia) remains poorly understood. Here we examine the role of the Doublesex-related transcription factor DMRT1 in adult spermatogenesis using conditional gene targeting in the mouse. Loss of Dmrt1 causes spermatogonia to precociously exit the spermatogonial program and enter meiosis. Dmrt1 therefore determines whether male germ cells undergo mitosis and spermatogonial differentiation or meiosis. Loss of Dmrt1 in spermatogonia also disrupts cyclical gene expression in Sertoli cells. DMRT1 acts in spermatogonia to restrict RA responsiveness, directly repress Stra8 transcription, and activate transcription of the spermatogonial differentiation factor Sohlh1, thereby preventing meiosis and promoting spermatogonial development. By coordinating spermatogonial development and mitotic amplification with meiosis, DMRT1 allows abundant, continuous production of sperm.
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Cites
Retinoid-binding proteins: mediators of retinoid action
NOY, N. (2000) · Biochemical Journal · doi:10.1042/bj3480481 · Cited by 422
Dong, D., Ruuska, S. E., Levinthal, D. J., & Noy, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23695 · Cited by 362
Cited by
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
Self-citationSingle-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions
Li, L., Dong, J., Yan, L., Yong, J., Liu, X., Hu, Y., Fan, X., Wu, X., Guo, H., Wang, X., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.03.007 · Cited by 561
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“Recent work supports the conclusion that the vitamin A metabolite, RA, is needed both for adult male spermatogonial differentiation (transition to A1) and the entrance into meiosis [45–47].”
ResultSex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Human germ cell tumours from a developmental perspective
Oosterhuis, J. W., & Looijenga, L. H. J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0178-9 · Cited by 328
Metadata
- Authors
- Matson, C. K., Murphy, M. W., Griswold, M. D., Yoshida, S., Bardwell, V. J., & Zarkower, D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 19
- Issue
- 4
- Pages
- 612-624
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2041784242
- Cited by
- 368
- References
- 2
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matson, C. K., Murphy, M. W., Griswold, M. D., Yoshida, S., Bardwell, V. J., & Zarkower, D. (2010). The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells. Developmental Cell. https://doi.org/10.1016/j.devcel.2010.09.010
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