The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes
Open accessAbstract
SUMMARY Polyphosphoinositides are lipid signaling molecules generated from phosphatidylinositol (PtdIns) with critical roles in vesicular trafficking and signaling. It is poorly understood where PtdIns is located within cells and how it moves around between membranes. Here we identify a hitherto unrecognized highly mobile membrane compartment as the site of PtdIns synthesis and a likely source of PtdIns of all membranes. We show that the PtdIns synthesizing enzyme, PIS associates with a rapidly moving compartment of ER origin that makes ample contacts with other membranes. In contrast, CDP-diacylglycerol synthases that provide PIS with its substrate reside in the tubular ER. Expression of a PtdIns-specific bacterial PLC generates diacylglycerol also in rapidly moving cytoplasmic objects. We propose a model in which PtdIns is synthesized in a highly mobile lipid distribution platform and is delivered to other membranes during multiple contacts by yet to be defined lipid transfer mechanisms.
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Cites
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.
Inoue, T., Heo, W. D., Grimley, J. S., Wandless, T. J., & Meyer, T. (2005) · Nature Methods · doi:10.1038/nmeth763 · Cited by 424 · cited 1×
“To target the enzyme to the PM, we added the Lyn N-terminal PM targeting sequence (Inoue et al., 2005) to its N terminus (Figure 6A).”
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Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Self-citationLipid landscapes and pipelines in membrane homeostasis
Holthuis, J. C. M., & Menon, A. K. (2014) · Nature · doi:10.1038/nature13474 · Cited by 901
Bigay, J., & Antonny, B. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.009 · Cited by 567
Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
Dickson, E. J., & Hille, B. (2019) · Biochemical Journal · doi:10.1042/bcj20180022 · Cited by 254
Rab10 GTPase regulates ER dynamics and morphology
English, A. R., & Voeltz, G. K. (2013) · Nature Cell Biology · doi:10.1038/ncb2647 · Cited by 224
Metadata
- Authors
- Kim, Y. J., Guzman-Hernandez, M. L., & Balla, T.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 21
- Issue
- 5
- Pages
- 813-824
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2058992886
- Cited by
- 205
- References
- 1
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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