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Cited by 366

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

Open access
Weber, Gregory F., Bjerke, Maureen A., DeSimone, Douglas W.·2012·Developmental Cell
DOI 10.1016/j.devcel.2011.10.013
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Abstract

Summary Collective cell migration requires maintenance of adhesive contacts between adjacent cells, coordination of polarized cell protrusions, and generation of propulsive traction forces. We demonstrate that mechanical force applied locally to C-cadherins on single Xenopus mesendoderm cells is sufficient to induce polarized cell protrusion and persistent migration typical of individual cells within a collectively migrating tissue. Local tension on cadherin adhesions induces reorganization of the keratin intermediate filament network toward these stressed sites. Plakoglobin, a member of the catenin family, is localized to cadherin adhesions under tension and is required for both mechanoresponsive cell behavior and assembly of the keratin cytoskeleton at the rear of these cells. Local tugging forces on cadherins occur in vivo through interactions with neighboring cells, and these forces result in coordinate changes in cell protrusive behavior. Thus, cadherin-dependent force-inducible regulation of cell polarity in single mesendoderm cells represents an emergent property of the intact tissue.

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Metadata

Authors
Weber, G. F., Bjerke, M. A., & DeSimone, D. W.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2012-01
Volume
22
Issue
1
Pages
104-115
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2011.10.013
OpenAlex
W1963773881
Cited by
366
References
50
FWCI
12.12
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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