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MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
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Mmp14 haploinsufficient (Mmp14+/−) mice do not display gross postnatal phenotypes.
“Mmp14 haploinsufficient (Mmp14+/−) mice, which do not display gross postnatal phenotypes24–26.”
From MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity (2025) · cites this paper as [26]
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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8641 · Cited by 483
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- Barbolina, 2008, Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis, Semin. Cell Dev. Biol., 19, 24, 10.1016/j.semcdb.2007.06.008 · DOI
- Cabrita, 2003, Sprouty proteins: antagonists of endothelial cell signaling and more, Thromb. Haemost., 90, 586, 10.1160/TH03-04-0217 · DOI
- Catela, 2009, Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice, Dis. Model. Mech., 2, 283, 10.1242/dmm.002287 · DOI
- Celli, 1998, Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning, EMBO J., 17, 1642, 10.1093/emboj/17.6.1642 · DOI
- Deng, 1994, Murine FGFR-1 is required for early postimplantation growth and axial organization, Genes Dev., 8, 3045, 10.1101/gad.8.24.3045 · DOI
- Ding, 2011, Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization, Cell, 147, 539, 10.1016/j.cell.2011.10.003 · DOI
- Foster, 2002, Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice, Differentiation, 70, 624, 10.1046/j.1432-0436.2002.700915.x · DOI
- Fürthauer, 2002, Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling, Nat. Cell Biol., 4, 170, 10.1038/ncb750 · DOI
- Holmbeck, 1999, MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover, Cell, 99, 81, 10.1016/S0092-8674(00)80064-1 · DOI · Paper page
- Holmbeck, 2003, MT1-MMP-dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth, J. Cell Biol., 163, 661, 10.1083/jcb.200307061 · DOI
- Holmbeck, 2005, The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone, J. Cell Sci., 118, 147, 10.1242/jcs.01581 · DOI
- Ignelzi, 2003, Fibroblast growth factors lead to increased Msx2 expression and fusion in calvarial sutures, J. Bone Miner. Res., 18, 751, 10.1359/jbmr.2003.18.4.751 · DOI
- Inoue, 2006, A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism, J. Biol. Chem., 281, 33814, 10.1074/jbc.M607290200 · DOI
- Kim, 1998, FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development, Development, 125, 1241, 10.1242/dev.125.7.1241 · DOI
- Kim, 2003, Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure, Dev. Dyn., 227, 335, 10.1002/dvdy.10319 · DOI
- Levi, 1996, Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1, Proc. Natl. Acad. Sci. USA, 93, 7069, 10.1073/pnas.93.14.7069 · DOI
- Li, 2010, Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived bone, PLoS One, 5, e14033, 10.1371/journal.pone.0014033 · DOI
- Liu, 2009, TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling, Mol. Cell, 35, 26, 10.1016/j.molcel.2009.06.018 · DOI
- Liu, 2002, Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18, Genes Dev., 16, 859, 10.1101/gad.965602 · DOI
- Maas, 1996, The role of Msx genes in mammalian development, Ann. N Y Acad. Sci., 785, 171, 10.1111/j.1749-6632.1996.tb56256.x · DOI
- Maretzky, 2009, Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer, Cancer Res., 69, 4573, 10.1158/0008-5472.CAN-08-4766 · DOI
- Maretzky, 2009, Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays, Biochem. J., 420, 105, 10.1042/BJ20082127 · DOI
- Maretzky, 2011, A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17, Oncogene, 30, 611, 10.1038/onc.2010.443 · DOI
- Maruyama, 2010, The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development, Sci. Signal., 3, ra40, 10.1126/scisignal.2000727 · DOI
- Miettinen, 1999, Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure, Nat. Genet., 22, 69, 10.1038/8773 · DOI
- Miraoui, 2010, Fibroblast growth factor receptor signaling crosstalk in skeletogenesis, Sci. Signal., 3, re9, 10.1126/scisignal.3146re9 · DOI
- Mosig, 2007, Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth, Hum. Mol. Genet., 16, 1113, 10.1093/hmg/ddm060 · DOI
- Oblander, 2005, Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation, Dev. Biol., 277, 255, 10.1016/j.ydbio.2004.09.033 · DOI
- Ohbayashi, 2002, FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis, Genes Dev., 16, 870, 10.1101/gad.965702 · DOI
- Onguchi, 2009, Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization, Am. J. Pathol., 174, 1564, 10.2353/ajpath.2009.080452 · DOI
- Ornitz, 2002, FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease, Genes Dev., 16, 1446, 10.1101/gad.990702 · DOI
- Peduto, 2009, ADAM9 as a potential target molecule in cancer, Curr. Pharm. Des., 15, 2282, 10.2174/138161209788682415 · DOI
- Peduto, 2005, Critical function for ADAM9 in mouse prostate cancer, Cancer Res., 65, 9312, 10.1158/0008-5472.CAN-05-1063 · DOI
- Powers, 2000, Fibroblast growth factors, their receptors and signaling, Endocr. Relat. Cancer, 7, 165, 10.1677/erc.0.0070165 · DOI · Paper page
- Ramasamy, 2007, Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development, Dev. Biol., 307, 237, 10.1016/j.ydbio.2007.04.033 · DOI
- Rice, 2000, Integration of FGF and TWIST in calvarial bone and suture development, Development, 127, 1845, 10.1242/dev.127.9.1845 · DOI
- Satokata, 1994, Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development, Nat. Genet., 6, 348, 10.1038/ng0494-348 · DOI
- Satokata, 2000, Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation, Nat. Genet., 24, 391, 10.1038/74231 · DOI · Paper page
- Schneider, 2009, The EGFR network in bone biology and pathology, Trends Endocrinol. Metab., 20, 517, 10.1016/j.tem.2009.06.008 · DOI
- Sleeman, 2001, Identification of a new fibroblast growth factor receptor, FGFR5, Gene, 271, 171, 10.1016/S0378-1119(01)00518-2 · DOI
- Smith, 2005, Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite, Development, 132, 1305, 10.1242/dev.01699 · DOI
- Sugiyama, 2010, FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex, Proc. Natl. Acad. Sci. USA, 107, 15786, 10.1073/pnas.0914459107 · DOI
- Trueb, 2011, Biology of FGFRL1, the fifth fibroblast growth factor receptor, Cell. Mol. Life Sci., 68, 951, 10.1007/s00018-010-0576-3 · DOI
- Werb, 1997, ECM and cell surface proteolysis: regulating cellular ecology, Cell, 91, 439, 10.1016/S0092-8674(00)80429-8 · DOI
- Weskamp, 2002, Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life, Mol. Cell. Biol., 22, 1537, 10.1128/MCB.22.5.1537-1544.2002 · DOI
- Xu, 1998, Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction, Development, 125, 753, 10.1242/dev.125.4.753 · DOI
- Yamaguchi, 1994, fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation, Genes Dev., 8, 3032, 10.1101/gad.8.24.3032 · DOI
- Yu, 2003, Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth, Development, 130, 3063, 10.1242/dev.00491 · DOI
- Zhou, 2000, Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I, Proc. Natl. Acad. Sci. USA, 97, 4052, 10.1073/pnas.060037197 · DOI · Paper page
Cited by
Sorted by citations
Zhu, L., Tang, Y., Li, X.-Y., Keller, E. T., Yang, J., Cho, J.-S., Feinberg, T. Y., & Weiss, S. J. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6143 · Cited by 178
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity
Asthana, P., Li, L., Lu, L., Wu, J., Zhang, S., Li, N., Wong, S. K. K., Gurung, S., Zhang, Y., Lin, Y., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00825-w · Cited by 4
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Metadata
- Authors
- Chan, K. M., Wong, H. L. X., Jin, G., Liu, B., Cao, R., Cao, Y., Lehti, K., Tryggvason, K., & Zhou, Z.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 22
- Issue
- 6
- Pages
- 1176-1190
- ISSN
- 1534-5807
- Cited by
- 83
- References
- 1
- Language
- en
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