Cited by 178Bone Metabolism and DiseasesProtease and Inhibitor MechanismsBone and Dental Protein Studies

Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases

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Zhu, Lingxin, Tang, Yi, Li, Xiao-Yan, Keller, Evan T., Yang, Jingwen, Cho, Jung-Sun, Feinberg, Tamar Y., Weiss, Stephen J.·2020·Science Translational Medicine

Abstract

Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption.

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Authors
Zhu, L., Tang, Y., Li, X.-Y., Keller, E. T., Yang, J., Cho, J.-S., Feinberg, T. Y., & Weiss, S. J.
Affiliations
  • University of Michigan (US)
  • Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Corresponding author
  • Zhu, Lingxin
  • Weiss, Stephen J.
Venue
Science Translational Medicine
Published
2020-02-05
Volume
12
Issue
529
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3005525925
Cited by
178
References
89
Citations by year
2026: 30 · 2025: 31 · 2024: 34 · 2023: 25 · 2022: 24 · 2021: 18 · 2020: 15 · 2015: 1
FWCI
6.65
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (AI105068, CA093900, CA071699, AR075168)
  • Breast Cancer Research Foundation
  • National Natural Science Foundation of China (81970919)
  • Margolies Family Discovery Fund for Cancer Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
osteoclasts, bone resorption, metalloproteinases, MMP-9, MMP-14, collagen degradation, bone mineral density, parathyroid hormone, ovariectomy, bone loss, therapeutic target
MeSH terms
Animals, Bone and Bones, Bone Resorption, Cathepsins, Female, Humans, Osteoclasts, Osteoporosis, Ovariectomy, Mice

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