A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

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MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content

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A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

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Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.Preprint

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

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Mutations in Two Nonhomologous Genes in a Head-to-Head Configuration Cause Ellis-van Creveld Syndrome

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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia

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The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia

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Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

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The Primary Cilium as a Hedgehog Signal Transduction Machine

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The ciliary transition zone: from morphology and molecules to medicine

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A new gene, EVC2, is mutated in Ellis–van Creveld syndrome

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Ellis–van Creveld syndrome and Weyers acrodental dysostosis are caused by cilia‐mediated diminished response to hedgehog ligands

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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

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Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism

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Widening the mutation spectrum ofEVCandEVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts hedgehog signaling

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Long interspersed nuclear element-1 (LINE1)-mediated deletion ofEVC,EVC2,C4orf6, andSTK32B in Ellis–van Creveld syndrome with borderline intelligence

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The mechanisms of Hedgehog signalling and its roles in development and disease

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Cellular signalling by primary cilia in development, organ function and disease

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Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

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Hedgehog Signaling: From Basic Biology to Cancer Therapy

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Hedgehog signaling mechanism and role in cancer

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A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

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Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

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EFCAB7 and IQCE Regulate Hedgehog Signaling by Tethering the EVC-EVC2 Complex to the Base of Primary Cilia

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