G-protein-coupled receptors, Hedgehog signaling and primary cilia

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Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants

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Vertebrate Smoothened functions at the primary cilium

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint

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Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426 · see citing works

Hedgehog signalling in the mouse requires intraflagellar transport proteins

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Intraflagellar transport

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A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis

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Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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Differential signal transduction by five splice variants of the PACAP receptor

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AKAP signalling complexes: focal points in space and time

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Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

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Small molecule modulation of Smoothened activity

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Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

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Structural basis of Wnt recognition by Frizzled

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Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

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Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> Signaling

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Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

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Cilia and Hedgehog responsiveness in the mouse

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Patched acts catalytically to suppress the activity of Smoothened

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The Dynamic Process of β2-Adrenergic Receptor Activation

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Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

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The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

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Gli1 is a target of Sonic hedgehog that induces ventral neural tube development

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Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

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Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

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How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

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Dynamic Association of Proteasomal Machinery with the Centrosome

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Perspectives on Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in the Neuroendocrine, Endocrine, and Nervous Systems

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Primary cilia are specialized calcium signalling organelles

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

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The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

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Assembly of allosteric macromolecular switches: lessons from PKA

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The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

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Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1

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Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR Review 1

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Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway

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Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

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Structure of the human smoothened receptor bound to an antitumour agent

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Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

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Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

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TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

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Dual and opposing roles of primary cilia in medulloblastoma development

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Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

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Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

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A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

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Constitutively active mutants of the alpha 1B‐adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

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Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.Preprint

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Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

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Transmembrane molecular pump activity of Niemann-Pick C1 protein.

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THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

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Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube.Preprint

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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

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Repression of Smoothened by Patched-Dependent (Pro-)Vitamin D3 Secretion

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Direct recording and molecular identification of the calcium channel of primary cilia

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

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Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

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Oxysterols Are Novel Activators of the Hedgehog Signaling Pathway in Pluripotent Mesenchymal Cells

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SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells

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Gli1can rescue the in vivo function ofGli2

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Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

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Oxysterols are allosteric activators of the oncoprotein Smoothened

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Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

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β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium

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Proteomic Analysis of Mammalian Primary Cilia

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Hedgehog regulates smoothened activity by inducing a conformational switch

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Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

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The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

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The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

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The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

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Multisite Protein Kinase A and Glycogen Synthase Kinase 3β Phosphorylation Leads to Gli3 Ubiquitination by SCF ^βTrCP

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Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2

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Activation of heterotrimeric G proteins by Smoothened

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Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

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Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation

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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

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Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

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Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

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IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport

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