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The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition
Open accessAbstract
SUMMARY Fenestral and stomatal diaphragms are endothelial subcellular structures of unknown function that form on organelles implicated in vascular permeability: fenestrae, transendothelial channels and caveolae. PV1 protein is required for diaphragm formation in vitro. Here, we report that deletion of the PV1-encoding Plvap gene in mice results in the absence of diaphragms and decreased survival. Loss of diaphragms did not affect the fenestrae and transendothelial channels formation but disrupted the barrier function of fenestrated capillaries causing a major leak of plasma proteins. This disruption results in early death of animals due to severe non-inflammatory protein loosing enteropathy. Deletion of PV1 in endothelium, but not the hematopoietic compartment, recapitulates the phenotype of global PV1 deletion, whereas endothelial reconstitution of PV1 rescues the phenotype. Taken together, these data provide genetic evidence for the critical role of the diaphragms in fenestrated capillaries in the maintenance of blood composition.
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Microvascular fluid exchange and the revised Starling principle
Levick, J. R., & Michel, C. C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq062 · Cited by 1,183
Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice
Herrnberger, L., Seitz, R., Kuespert, S., Bösl, M. R., Fuchshofer, R., & Tamm, E. R. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0987-3 · Cited by 76
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Bertocchi, A., Carloni, S., Ravenda, P. S., Bertalot, G., Spadoni, I., Lo Cascio, A., Gandini, S., Lizier, M., Braga, D., Asnicar, F., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.004 · Cited by 515
Development and Cell Biology of the Blood-Brain Barrier
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Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1807-1 · Cited by 436
Chakrabarti, R., Ji, W.-K., Stan, R. V., de Juan Sanz, J., Ryan, T. A., & Higgs, H. N. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709111 · Cited by 349
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Metadata
- Authors
- Stan, R. V., Tse, D., Deharvengt, S. J., Smits, N. C., Xu, Y., Luciano, M. R., McGarry, C. L., Buitendijk, M., Nemani, K. V., Elgueta, R., Kobayashi, T., Shipman, S. L., Moodie, K. L., Daghlian, C. P., Ernst, P. A., Lee, H.-K., Suriawinata, A. A., Schned, A. R., Longnecker, D. S., Fiering, S. N., Noelle, R. J., Gimi, B., Shworak, N. W., & Carrière, C.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 23
- Issue
- 6
- Pages
- 1203-1218
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2074432560
- Cited by
- 232
- References
- 2
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stan, R. V., Tse, D., Deharvengt, S. J., Smits, N. C., Xu, Y., Luciano, M. R., McGarry, C. L., Buitendijk, M., Nemani, K. V., Elgueta, R., Kobayashi, T., Shipman, S. L., Moodie, K. L., Daghlian, C. P., Ernst, P. A., Lee, H.-K., Suriawinata, A. A., Schned, A. R., Longnecker, D. S., . . . Carrière, C. (2012). The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition. Developmental Cell. https://doi.org/10.1016/j.devcel.2012.11.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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