INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division
Open accessAbstract
Mitochondrial division requires division of both the inner and outer mitochondrial membranes (IMM and OMM, respectively). Interaction with endoplasmic reticulum (ER) promotes OMM division by recruitment of the dynamin Drp1, but effects on IMM division are not well characterized. We previously showed that actin polymerization through ER-bound inverted formin 2 (INF2) stimulates Drp1 recruitment in mammalian cells. Here, we show that INF2-mediated actin polymerization stimulates a second mitochondrial response independent of Drp1: a rise in mitochondrial matrix calcium through the mitochondrial calcium uniporter. ER stores supply the increased mitochondrial calcium, and the role of actin is to increase ER–mitochondria contact. Myosin IIA is also required for this mitochondrial calcium increase. Elevated mitochondrial calcium in turn activates IMM constriction in a Drp1-independent manner. IMM constriction requires electron transport chain activity. IMM division precedes OMM division. These results demonstrate that actin polymerization independently stimulates the dynamics of both membranes during mitochondrial division: IMM through increased matrix calcium, and OMM through Drp1 recruitment.
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Inner membrane constriction occurs at ER-mitochondria contact sites before DRP1 recruitment and is independent of DRP1 action and OMM division.
“The inner membrane constriction occurs at ER–mitochondria contact sites before DRP1 recruitment and is thus independent of DRP1 action and OMM division [102, 103].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [103]
The mechanism driving IMM constriction is not elucidated, but the requirement of MCU and OMA1-induced OPA1S has been shown.
“The mechanism which drives IMM constriction are not elucidated, but the requirement of MCU and OMA1-induced OPA1S has been shown [102, 103].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [103]
MCU inhibition leads to mitochondrial elongation.
“In line with the reports suggesting a link between mitochondrial calcium overload and mitochondrial fragmentation [104, 105], MCU inhibition leads to mitochondrial elongation [103].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [103]
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- Authors
- Chakrabarti, R., Ji, W.-K., Stan, R. V., de Juan Sanz, J., Ryan, T. A., & Higgs, H. N.
- Affiliations
- Dartmouth College (US)
- Department of Biochemistry, Weill Cornell Medical College, New York, NY 2
- Weill Cornell Medicine (US)
- Corresponding author
- Higgs, Henry N.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2017-11-15
- Volume
- 217
- Issue
- 1
- Pages
- 251-268
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC5748994
- OpenAlex
- W2768967794
- Cited by
- 349
- References
- 71
- Citations by year
- 2026: 36 · 2025: 44 · 2024: 39 · 2023: 41 · 2022: 42 · 2021: 51 · 2020: 44 · 2019: 30 · 2018: 20 · 2017: 1
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM069818, GM106000, DK88826, NS036942, GM113132)
- National Institute of General Medical Sciences
- Provost and Dean of Sciences at Dartmouth College
- Norris Cotton Cancer Center
- William Ruger Senior Fund at Dartmouth (560118)
- Department of Biochemistry and Cell Biology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial division, INF2, actin polymerization, endoplasmic reticulum, mitochondrial calcium uptake, mitochondrial calcium uniporter, ER-mitochondria contact sites, Drp1, myosin IIA, electron transport chain
- MeSH terms
- Formins, Actins, Calcium, Cell Division, Endoplasmic Reticulum, Humans, Microfilament Proteins, Microtubule-Associated Proteins, Mitochondria, Ion Transport, GTP Phosphohydrolases, Mitochondrial Proteins, Dynamins, Cell Line, Tumor, Mitochondrial Membranes
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