Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease
Open accessAbstract
The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures display a peculiar morphology explained by their developmental origin, and fulfill several functions essential for CNS homeostasis. They form a neuroprotective barrier preventing the accumulation of noxious compounds into the CSF and brain, and secrete CSF, which participates in the maintenance of a stable CNS internal environment. The CSF circulation plays an important role in volume transmission within the developing and adult brain, and CSF compartments are key to the immune surveillance of the CNS. In these contexts, the choroid plexuses are an important source of biologically active molecules involved in brain development, stem cell proliferation and differentiation, and brain repair. By sensing both physiological changes in brain homeostasis and peripheral or central insults such as inflammation, they also act as sentinels for the CNS. Finally, their role in the control of immune cell traffic between the blood and the CSF confers on the choroid plexuses a function in neuroimmune regulation and implicates them in neuroinflammation. The choroid plexuses, therefore, deserve more attention while investigating the pathophysiology of CNS diseases and related comorbidities.
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The ChP epithelial sheet, together with vasculature and diverse cell types, regulates CSF secretion and composition by de novo protein synthesis and selective transcytosis of blood-borne factors.
“The foundation of the ChP is an epithelial sheet that, together with a network of vasculature and diverse cell types, regulates CSF secretion and governs its composition by de novo protein synthesis and selective transcytosis of blood-borne factors (Damkier et al., 2013; Ghersi-Egea et al., 2018; Lun et al., 2015a; Saunders et al., 2018b).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Ghersi-Egea et al., 2018
The choroid plexus in each brain ventricle produces cerebrospinal fluid and forms the blood-CSF barrier.
“The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier.”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Ghersi-Egea et al., 2018
The choroid plexus is a primary producer of cerebrospinal fluid and cerebrospinal fluid-distributed factors.
“The ChP is considered to be a primary producer of CSF and CSF-distributed factors (Ghersi-Egea et al., 2018; Lun et al., 2015a; Saunders et al., 2018b)”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Ghersi-Egea et al., 2018
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · see citing works
Tight junctions: from simple barriers to multifunctional molecular gates
Zihni, C., Mills, C., Matter, K., & Balda, M. S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.80 · Cited by 1,484 · see citing works
Origin, fate and dynamics of macrophages at central nervous system interfaces
Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3423 · Cited by 1,209 · see citing works
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works
Self-citationChaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980 · see citing works
The anatomical and cellular basis of immune surveillance in the central nervous system
Ransohoff, R. M., & Engelhardt, B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3265 · Cited by 975 · see citing works
Self-citationThe movers and shapers in immune privilege of the CNS
Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology · doi:10.1038/ni.3666 · Cited by 893 · see citing works
Self-citationAutoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works
New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain
Sawamoto, K., Wichterle, H., González-Pérez, Ó., Cholfin, J. A., Yamada, M., Spassky, N., Murcia, N. S., García‐Verdugo, J. M., Marín, Ó., Rubenstein, J. L. R., et al. (2006) · Science · doi:10.1126/science.1119133 · Cited by 803 · see citing works
Capture, crawl, cross: the T cell code to breach the blood–brain barriers
Engelhardt, B., & Ransohoff, R. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.07.004 · Cited by 686 · see citing works
Self-citationEffector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.
Bartholomäus, I., Kawakami, N., Odoardi, F., Schläger, C., Miljkovic, D., Ellwart, J. W., Klinkert, W. E. F., Flügel-Koch, C., Issekutz, T. B., Wekerle, H., et al. (2009) · Nature · doi:10.1038/nature08478 · Cited by 685 · see citing works
Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683 · see citing works
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
Lehtinen, M. K., Zappaterra, M. W., Chen, X., Yang, Y. J., Hill, A. D., Lun, M., Maynard, T., Gonzalez, D., Kim, S., Ye, P., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.023 · Cited by 648 · see citing works
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634 · see citing works
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works
Physiology of the CSF and Blood-Brain Barriers
Davson, H., & Segal, M. B. (1996) · Medical Entomology and Zoology · Cited by 576 · see citing works
Agrawal, S., Anderson, P., Durbeej, M., van Rooijen, N., Ivars, F., Opdenakker, G., & Sorokin, L. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051342 · Cited by 559 · see citing works
Kivisäkk, P., Mahad, D., Callahan, M. K., Trebst, C., Tucky, B. H., Wei, T., Wu, L., Bækkevold, E. S., Lassmann, H., Staugaitis, S. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1433000100 · Cited by 546 · see citing works
Oshio, K., Watanabe, H., Song, Y., Verkman, A. S., & Manley, G. T. (2004) · The FASEB Journal · doi:10.1096/fj.04-1711fje · Cited by 477 · see citing works
(1990) · Europe PMC (PubMed Central) · Cited by 463 · see citing works
The developmental fate of the cephalic mesoderm in quail-chick chimeras
Couly, G. F., Coltey, P. M., & Douarin, N. M. L. (1992) · Development · doi:10.1242/dev.114.1.1 · Cited by 448 · see citing works
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
Schläger, C., Körner, H., Krueger, M., Vidoli, S., Haberl, M., Mielke, D., Brylla, E., Issekutz, T., Cabañas, C., Nelson, P. J., et al. (2016) · Nature · doi:10.1038/nature16939 · Cited by 372 · see citing works
Cepok, S., Rosche, B., Grummel, V., Vogel, F., Zhou, D., Sayn, J., Sommer, N., Hartung, H., & Hemmer, B. (2005) · Brain · doi:10.1093/brain/awh486 · Cited by 367 · see citing works
Vascular, glial, and lymphatic immune gateways of the central nervous system
Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1606-5 · Cited by 362 · see citing works
Self-citationMapping of the early neural primordium in quail-chick chimeras
Couly, G. F., & Douarin, N. M. L. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90118-7 · Cited by 352 · see citing works
Corcione, A., Casazza, S., Ferretti, E., Giunti, D., Zappia, E., Pistorio, A., Gambini, C., Mancardi, G., Uccelli, A., & Pistoia, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402455101 · Cited by 349 · see citing works
Schwartz, M., & Baruch, K. (2014) · The EMBO Journal · doi:10.1002/embj.201386609 · Cited by 349 · see citing works
Balusu, S., Wonterghem, E. V., Rycke, R. M. D., Raemdonck, K., Stremersch, S., Gevaert, K., Brkić, M., Demeestere, D., Vanhooren, V., Hendrix, A., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606271 · Cited by 348 · see citing works
Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma
Grapp, M., Wrede, A., Schweizer, M., Hüwel, S., Galla, H., Snaidero, N., Simons, M., Bückers, J., Low, P. S., Urlaub, H., et al. (2013) · Nature Communications · doi:10.1038/ncomms3123 · Cited by 337 · see citing works
IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair
Kunis, G., Baruch, K., Rosenzweig, N., Kertser, A., Miller, O., Berkutzki, T., & Schwartz, M. (2013) · Brain · doi:10.1093/brain/awt259 · Cited by 321 · see citing works
Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells
Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.013 · Cited by 306 · see citing works
Baruch, K., Ron‐Harel, N., Gal, H., Deczkowska, A., Shifrut, E., Ndifon, W. O., Mirlas-Neisberg, N., Cardon, M., Vaknin, I., Cahalon, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211270110 · Cited by 296 · see citing works
Development and tissue origins of the mammalian cranial base
McBratney‐Owen, B., Iseki, S., Bamforth, S. D., Olsen, B. R., & Morriss‐Kay, G. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.07.016 · Cited by 296 · see citing works
Muto, S., Hata, M., Taniguchi, J., Tsuruoka, S., Moriwaki, K., Saitou, M., Furuse, K., Sasaki, H., Fujimura, A., Imai, M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912901107 · Cited by 293 · see citing works
Morphological Fate of Rhombomeres in Quail/Chick Chimeras: A Segmental Analysis of Hindbrain Nuclei
Marı́n, F., & Puelles, L. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00693.x · Cited by 289 · see citing works
Cilia-based flow network in the brain ventricles
Faubel, R., Westendorf, C., Bodenschatz, E., & Gregor Eichele, C. (2016) · Science · doi:10.1126/science.aae0450 · Cited by 279 · see citing works
In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI
Aoki, I., Wu, Y.-J. L., Silva, A. C., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.031 · Cited by 271 · see citing works
Strazielle, N., & Ghersi‐Egea, J. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300518e · Cited by 262 · see citing works
Self-citationKeep, R. F., & Jones, H. C. (1990) · Developmental Brain Research · doi:10.1016/0165-3806(90)90163-s · Cited by 257 · see citing works
Engelhardt, B., & Coisne, C. (2011) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-8-4 · Cited by 247 · see citing works
Self-citationSteffen, B. J., Breier, G., Butcher, E. C., Schulz, M., & Engelhardt, B. (1996) · Europe PMC (PubMed Central) · Cited by 245 · see citing works
Self-citationRoberts, L. M., Black, D. S., Raman, C., Woodford, K., Zhou, M., Haggerty, J. E., Yan, A. T., Cwirla, S. E., & Grindstaff, K. K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.015 · Cited by 240 · see citing works
The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition
Stan, R. V., Tse, D., Deharvengt, S. J., Smits, N. C., Yan, X., Luciano, M. R., McGarry, C. L., Buitendijk, M., Nemani, K. V., Elgueta, R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.11.003 · Cited by 233 · see citing works
Ghersi‐Egea, J. ‐., Gorevic, P. D., Ghiso, J., Frangione, B., Patlak, C. S., & Fenstermacher, J. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020880.x · Cited by 222 · cited 1× · see citing works
“The CSF circulation plays a role in amyloid beta distribution and clearance from the brain [49].”
BackgroundSelf-citationBrain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
Steinbach, K., Vincenti, I., Kreutzfeldt, M., Pagé, N., Muschaweckh, A., Wagner, I., Drexler, I., Pinschewer, D. D., Korn, T., & Merkler, D. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151916 · Cited by 212 · see citing works
Wolburg, H., Wolburg-Buchholz, K., Liebner, S., & Engelhardt, B. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01927-9 · Cited by 210 · see citing works
Self-citationRichard, K., Hume, R., Kaptein, E., Stanley, E. L., Visser, T. J., & Coughtrie, M. W. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.6.7569 · Cited by 209 · see citing works
Brown, D. A., & Sawchenko, P. E. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21307 · Cited by 200 · see citing works
Kokovay, E., Wang, Y., Kusek, G., Wurster, R., Lederman, P. L., Lowry, N. A., Shen, Q., & Temple, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.016 · Cited by 199 · see citing works
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198 · see citing works
Self-citationMiyata, S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00390 · Cited by 191 · see citing works
Imayoshi, I., Shimogori, T., Ohtsuka, T., & Kageyama, R. (2008) · Development · doi:10.1242/dev.021535 · Cited by 190 · see citing works
T‐cell trafficking in the central nervous system
Sallusto, F., Impellizzieri, D., Basso, C., Laroni, A., Uccelli, A., Lanzavecchia, A., & Engelhardt, B. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01140.x · Cited by 186 · see citing works
Self-citationVEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma
Maharaj, A. S. R., Walshe, T. E., Saint‐Geniez, M., Venkatesha, S., Maldonado, A. E., Himes, N. C., Matharu, K., Karumanchi, S. A., & D'Amore, P. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072041 · Cited by 186 · see citing works
Strazielle, N., & Ghersi‐Egea, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06275.1999 · Cited by 184 · see citing works
Self-citationDelgado, A. C., Ferrón, S. R., Vicente, D., Porlan, E., Pérez‐Villalba, A., Trujillo, C. M., D’Ocón, P., & Fariñas, I. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.015 · Cited by 183 · see citing works
Cobos, I., Shimamura, K., Rubenstein, J. L. R., Martı́nez, S., & Puelles, L. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0423 · Cited by 182 · see citing works
Morphological alterations of the choroid plexus in late-onset Alzheimer’s disease
Sérot, J., Béné, M. C., Foliguet, B., & Faure, G. C. (2000) · Acta Neuropathologica · doi:10.1007/pl00007412 · Cited by 181 · see citing works
Giunti, D., Borsellino, G., Benelli, R., Marchese, M., Capello, E., Valle, M. T., Pedemonte, E., Noonan, D. M., Albini, A., Bernardi, G., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1202598 · Cited by 180 · see citing works
Lun, M. P., Johnson, M. B., Broadbelt, K. G., Watanabe, M., Kang, Y., Chau, K. F., Springel, M. W., Malesz, A., Sousa, A. M. M., Pletikos, M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3081-14.2015 · Cited by 178 · see citing works
Vercellino, M., Votta, B., Condello, C., Piacentino, C., Romagnolo, A., Merola, A., Capello, E., Mancardi, G., Mutani, R., Giordana, M. T., et al. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.035 · Cited by 176 · see citing works
Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity
Spatazza, J., Lee, H. H. C., Di Nardo, A. A., Tibaldi, L., Joliot, A., Hensch, T. K., & Prochiantz, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.014 · Cited by 176 · see citing works
BARRIER MECHANISMS IN THE BRAIN, II. IMMATURE BRAIN
Saunders, N. R., Habgood, M., & Dziegielewska, K. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.02987.x · Cited by 173 · see citing works
THE DEVELOPMENT OF THE HUMAN BLOOD‐BRAIN AND BLOOD‐CSF BARRIERS
Møllgård, K., & Saunders, N. R. (1986) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1986.tb00146.x · Cited by 171 · see citing works
Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development
Huang, X., Liu, J., Ketova, T., Fleming, J. T., Grover, V. K., Cooper, M. K., Litingtung, Y., & Chiang, C. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911838107 · Cited by 167 · see citing works
Exosomes as Novel Regulators of Adult Neurogenic Niches
Bátiz, L. F., Castro, M. A., Burgos, P. V., Velásquez, Z. D., Muñoz, R. I., Lafourcade, C., Troncoso-Escudero, P., & Wyneken, Ú. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00501 · Cited by 157 · see citing works
Efflux transporters in blood-brain interfaces of the developing brain
Strazielle, N., & Ghersi‐Egea, J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00021 · Cited by 155 · see citing works
Self-citationNeuroinvasion and Inflammation in Viral Central Nervous System Infections
Dahm, T., Rudolph, H., Schwerk, C., Schroten, H., & Tenenbaum, T. (2016) · Mediators of Inflammation · doi:10.1155/2016/8562805 · Cited by 155 · see citing works
The Role of the Choroid Plexus in Neutrophil Invasion after Traumatic Brain Injury
Szmydynger‐Chodobska, J., Strazielle, N., Zink, B. J., Ghersi‐Egea, J., & Chodobski, A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.71 · Cited by 151 · see citing works
Self-citationGhersi‐Egea, J., Finnegan, W., Chen, J.-L., & Fenstermacher, J. D. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00281-3 · Cited by 151 · see citing works
Self-citationCentral memory CD4+ T cells dominate the normal cerebrospinal fluid
de Graaf, M. T., Smitt, P. A. E. S., Luitwieler, R. L., et al. (2010) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20542 · Cited by 149 · see citing works
The choroid plexus—a multi-role player during infectious diseases of the CNS
Schwerk, C., Tenenbaum, T., Kim, K. S., & Schroten, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00080 · Cited by 147 · see citing works
The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels
Couly, G. F., Coltey, P. M., Eichmann, A., & Douarin, N. M. L. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00428-9 · Cited by 146 · see citing works
Gazzin, S., Strazielle, N., Schmitt, C., Fèvre‐Montange, M., Ostrow, J. D., Tiribelli, C., & Ghersi‐Egea, J. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21808 · Cited by 144 · see citing works
Self-citationLodygin, D., Odoardi, F., Schläger, C., Körner, H., Kitz, A., Nosov, M., van den Brandt, J., Reichardt, H. M., Haberl, M., & Flügel, A. (2013) · Nature Medicine · doi:10.1038/nm.3182 · Cited by 144 · see citing works
Brain size and limits to adult neurogenesis
Paredes, M. F., Sorrells, S. F., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23896 · Cited by 142 · see citing works
González-Marrero, I., Giménez‐Llort, L., Johanson, C. E., Carmona-Calero, E. M., Castañeyra-Ruiz, L., Armas, J. M. B., Castañeyra-Perdomo, A., & Castro-Fuentes, R. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00017 · Cited by 140 · see citing works
Cortical lesions and brain atrophy in MS.
Kutzelnigg, A., & Lassmann, H. (2005) · Journal of Neurological Sciences · doi:10.1016/j.jns.2005.03.027 · Cited by 137 · see citing works
Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis
Paul, A., Chaker, Z., & Doetsch, F. (2017) · Science · doi:10.1126/science.aal3839 · Cited by 137 · cited 1× · see citing works
“It also directly synthesizes hormones and neuropeptides (including growth hormone, vasopressin, and insulin-like growth factor 1), as well as peptide processing enzymes (including for proopiomelanocortin and insulin) and modifying enzymes (such as prostaglandin D2 synthase), which can affect adult V-SVZ neural stem ce…”
BackgroundLi, Y., Chen, J., & Chopp, M. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00657-8 · Cited by 131 · see citing works
Grapp, M., Just, I. A., Linnankivi, T., et al. (2012) · Brain · doi:10.1093/brain/aws122 · Cited by 130 · see citing works
The transcription factor Otx2 regulates choroid plexus development and function
Johansson, P. A., Irmler, M., Acampora, D., Beckers, J., Simeone, A., & Götz, M. (2013) · Development · doi:10.1242/dev.090860 · Cited by 130 · see citing works
Posttraumatic Invasion of Monocytes across the Blood—Cerebrospinal Fluid Barrier
Szmydynger-Chodobska, J., Strazielle, N., Gandy, J., Keefe, T. H., Zink, B., Ghersi-Egea, J., & Chodobski, A. (2012) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2011.111 · Cited by 129 · see citing works
Self-citationHistogenesis of choroid plexus in man
Shuangshotĭ, S., & Netsky, M. G. (1966) · American Journal of Anatomy · doi:10.1002/aja.1001180114 · Cited by 128 · see citing works
Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier
Kratzer, I., Vasiljevic, A., Rey, C., Fèvre‐Montange, M., Saunders, N. R., Strazielle, N., & Ghersi‐Egea, J. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-1001-9 · Cited by 127 · see citing works
Self-citationApplication of the Quail-Chick Chimera System to the Study of Brain Development and Behavior
Balaban, E., Teillet, M., & Douarin, N. M. L. (1988) · Science · doi:10.1126/science.3413496 · Cited by 127 · see citing works
Skipor, J., & Thiéry, J. (2008) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2008-1708 · Cited by 127 · see citing works
Sasseville, V. G., Newman, W., Lackner, A. A., Smith, M. O., Lausen, N., Beall, D., & Ringler, D. J. (1992) · PubMed Central · Cited by 126 · see citing works
Richardson, S. J., Wijayagunaratne, R. C., D’Souza, D. G., Darras, V., & Herck, S. L. J. V. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00066 · Cited by 126 · see citing works
CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T‐cell recruitment to target tissues
Villares, R., Cadenas, V., Lozano, M. D., Almonacid, L., Zaballos, Á., Martínez‐A, C., & Varona, R. (2009) · European Journal of Immunology · doi:10.1002/eji.200839123 · Cited by 126 · see citing works
Transport across the choroid plexus epithelium
Prætorius, J., & Damkier, H. H. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00041.2017 · Cited by 126 · see citing works
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Deczkowska, A., Baruch, K., & Schwartz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.006 · Cited by 125 · see citing works
The choroid plexus is a key cerebral invasion route for T cells after stroke
Llovera, G., Benakis, C., Enzmann, G. U., Cai, R., Arzberger, T., Ghasemigharagoz, A., Mao, X., Malik, R., Lazarevic, I., Liebscher, S., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1758-y · Cited by 124 · see citing works
Self-citationDirect and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation
Currle, D. S., Cheng, X., Hsu, C.-M., & Monuki, E. S. (2005) · Development · doi:10.1242/dev.01915 · Cited by 123 · see citing works
Lippoldt, A., Liebner, S., Andbjer, B., Kalbacher, H., Wolburg, H., Haller, H. G., & Fuxé, K. (2000) · Neuroreport · doi:10.1097/00001756-200005150-00015 · Cited by 123 · see citing works
Coles, J. A., Myburgh, E., Brewer, J. M., & McMenamin, P. G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.002 · Cited by 123 · see citing works
Marques, F., Sousa, J. C., Coppola, G., Falcão, A. M., Rodrigues, A. J., Geschwind, D. H., Sousa, N., Correia‐Neves, M., & Palha, J. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.15 · Cited by 122 · see citing works
Antioxidant Enzymes and Related Trace Elements in Aging Brain Capillaries and Choroid Plexus
Tayarani, I., Cloëz, I., Clément, M., et al. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb11778.x · Cited by 120 · see citing works
Claudin‐2‐mediated cation and water transport share a common pore
Rosenthal, R., Günzel, D., Krug, S. M., Schulzke, J., Fromm, M., & Yu, A. S. L. (2016) · Acta Physiologica · doi:10.1111/apha.12742 · Cited by 120 · see citing works
An immune paradox: How can the same chemokine axis regulate both immune tolerance and activation?
Comerford, I., Bunting, M. D., Fenix, K. A., Haylock‐Jacobs, S., Litchfield, W., Harata‐Lee, Y., Turvey, M. E., Brazzatti, J. A., Whyte, C. E., Nguyen, P., et al. (2010) · BioEssays · doi:10.1002/bies.201000063 · Cited by 118 · see citing works
Sérot, J., Zmudka, J., & Jouanny, P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111964 · Cited by 114 · see citing works
Disturbed function of the blood–cerebrospinal fluid barrier aggravates neuro-inflammation
Kooij, G., Kopplin, K., Blasig, R., Stuiver, M., Koning, N., Goverse, G., van der Pol, S. M. A., Hof, B. V. H., Gollasch, M., Drexhage, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1227-1 · Cited by 113 · see citing works
Martín, C., Bueno, D., Alonso, M. I., Moro, J. A., Callejo, S., Parada, C., Martín, P., Carnicero, E., & Gato, A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.05.010 · Cited by 111 · see citing works
Uchida, Y., Zhang, Z., Tachikawa, M., & Terasaki, T. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13147 · Cited by 108 · see citing works
Paracellular epithelial sodium transport maximizes energy efficiency in the kidney
Pei, L., Solis, G., Nguyen, M. T. X., Kamat, N. V., Magenheimer, L., Zhuo, M., Li, J., Curry, J. N., McDonough, A. A., Fields, T. A., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83942 · Cited by 108 · see citing works
Chau, K. F., Springel, M. W., Broadbelt, K. G., Park, H., Topal, S., Lun, M. P., Mullan, H., Maynard, T. M., Steen, H., LaMantia, A., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.015 · Cited by 101 · see citing works
Tight junctions in Schwann cells of peripheral myelinated axons
Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., et al. (2005) · Journal of Cell Biology · doi:10.1083/jcb.200501154 · Cited by 95 · see citing works
Rieckmann, P., Nünke, K., Burchhardt, M., et al. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90023-r · Cited by 94 · see citing works
Sérot, J., Foliguet, B., Béné, M. C., et al. (1997) · Neuroreport · doi:10.1097/00001756-199705260-00039 · Cited by 91 · see citing works
Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection
Kratzer, I., Liddelow, S. A., Saunders, N. R., Dzięgielewska, K. M., Strazielle, N., & Ghersi‐Egea, J. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-25 · Cited by 88 · see citing works
Self-citationUltrastructural localization of adhesion molecules in the healthy
Wolburg‐Buchholz, K., Gerhardt, H., Schulz, M., Wolburg, H., & Engelhardt, B. (1999) · Cell and Tissue Research · doi:10.1007/s004410051287 · Cited by 87 · see citing works
Self-citationInfluence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesis
Yamamoto, M., McCaffery, P. J. A., & Dräger, U. C. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(96)00038-7 · Cited by 85 · see citing works
Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica
Guo, Y. X., Weigand, S. D., Popescu, B. F. G., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L., & Lucchinetti, C. F. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1682-1 · Cited by 84 · see citing works
Immunological function of the blood-cerebrospinal fluid barrier.
Nathanson, J. A., & Chun, L. L. Y. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1684 · Cited by 83 · see citing works
Strazielle, N., Creidy, R., Malcus, C., Boucraut, J., & Ghersi‐Egea, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150945 · Cited by 83 · see citing works
Self-citationThe choroid plexuses and their impact on developmental neurogenesis
Johansson, P. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00340 · Cited by 81 · see citing works
Iwamoto, N., Higashi, T., & Furuse, M. (2013) · Cell Structure and Function · doi:10.1247/csf.13015 · Cited by 79 · see citing works
Restorick, S. M., Durant, L., Kalra, S., Hassan‐Smith, G., Rathbone, E. J., Douglas, M. R., & Curnow, J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.03.008 · Cited by 79 · see citing works
Liddelow, S. A., Dzięgielewska, K. M., Ek, C. J., Habgood, M. D., Bauer, H., Bauer, H., Lindsay, H. A., Wakefield, M. J., Strazielle, N., Kratzer, I., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065629 · Cited by 78 · see citing works
Self-citationCerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI
Bock, N. A., Paiva, F. F., Nascimento, G., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.065 · Cited by 77 · see citing works
Water channels and barriers formed by claudins
Rosenthal, R., Günzel, D., Theune, D., Czichos, C., Schulzke, J., & Fromm, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13383 · Cited by 76 · see citing works
2-photon imaging of phagocyte-mediated T cell activation in the CNS
Pesic, M., Bartholomäus, I., Kyratsous, N. I., Heissmeyer, V., Wekerle, H., & Kawakami, N. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67233 · Cited by 71 · see citing works
Immunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis
Alvermann, S., Hennig, C., Stüve, O., Wiendl, H., & Stangel, M. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.395 · Cited by 70 · see citing works
Millward, J. M., Schnorr, J., Taupitz, M., Wagner, S., Wuerfel, J. T., & Infante‐Duarte, C. (2013) · ASN NEURO · doi:10.1042/an20120081 · Cited by 69 · see citing works
The choroid plexus as a sex hormone target: Functional implications
Santos, C. R. A., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., Palha, J. A., & Gonçalves, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.002 · Cited by 66 · see citing works
Hasselblatt, M., Mertsch, S., Koos, B., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3176 · Cited by 62 · see citing works
The Effects of Cerebral Ischemia on the Rat Choroid Plexus
Ennis, S. R., & Keep, R. F. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600224 · Cited by 59 · see citing works
Ghersi‐Egea, J., Strazielle, N., Murat-Ringot, A., Jouvet, A., Buénerd, A., & Belin, M. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600267 · Cited by 58 · see citing works
Self-citationSteinemann, A., Galm, I., Chip, S., Nitsch, C., & Maly, I. P. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00016 · Cited by 58 · see citing works
A QUANTITATIVE STUDY OF CELL PROLIFERATION IN EPENDYMA AND CHOROID PLEXUS IN THE POSTNATAL RAT BRAIN
CHAUHAN, A. N., & Lewis, P. D. (1979) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1979.tb00629.x · Cited by 55 · see citing works
Gender associated circadian oscillations of the clock genes in rat choroid plexus
Quintela, T., Sousa, C., Patriarca, F. M., Gonçalves, I., & Santos, C. R. A. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0720-1 · Cited by 55 · see citing works
Campos, Y., Qiu, X., Gomero, E. M., Wakefield, R., HORNER, L. H., Brutkowski, W., Han, Y.-G., Solecki, D. J., Frase, S., Bongiovanni, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11876 · Cited by 55 · see citing works
Tang, Y. P., Haslam, S. Z., Conrad, S. E., & Sisk, C. L. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6409 · Cited by 49 · see citing works
Stridh, L., Ek, C. J., Wang, X., Nilsson, H., & Mallard, C. E. (2013) · Translational Stroke Research · doi:10.1007/s12975-012-0248-8 · Cited by 49 · see citing works
TLR2-mediated leukocyte trafficking to the developing brain
Mottahedin, A., Smith, P. L. P., Hagberg, H., Ek, C. J., & Mallard, C. E. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a1215-568r · Cited by 49 · see citing works
Nataf, S., Strazielle, N., Hatterer, E., Mouchiroud, G., Belin, M., & Ghersi‐Egea, J. (2006) · Glia · doi:10.1002/glia.20373 · Cited by 48 · see citing works
Self-citationScherrmann, J. M. (2010) · Springer eBooks · doi:10.1007/978-3-540-68706-1_1096 · Cited by 48 · see citing works
Matsumoto, K., Chiba, Y., Fujihara, R., Kubo, H., Sakamoto, H., & Ueno, M. (2015) · Histochemistry and Cell Biology · doi:10.1007/s00418-015-1366-7 · Cited by 46 · see citing works
Gazzin, S., Strazielle, N., Tiribelli, C., & Ghersi‐Egea, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00089 · Cited by 46 · see citing works
Self-citationPostnatal developmental changes in blood flow to choroid plexuses and cerebral cortex of the rat
Szmydynger‐Chodobska, J., Chodobski, A., & Johanson, C. E. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.5.r1488 · Cited by 45 · see citing works
Nonami, Y., Narita, K., Nakamura, H., et al. (2013) · Cytoskeleton · doi:10.1002/cm.21132 · Cited by 44 · see citing works
Tachikawa, M., Ozeki, G., Higuchi, T., et al. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12018 · Cited by 43 · see citing works
Proliferative activity and nestin expression in periventricular cells of the adult rat brain
Chouaf, L., Fèvre‐Montange, M., Brisson, C., Strazielle, N., Gamrani, H., & Didier‐Bazès, M. (2003) · Neuroreport · doi:10.1097/00001756-200303240-00022 · Cited by 42 · see citing works
Self-citationProvencio, J. J., Kivisäkk, P., Tucky, B. H., Luciano, M. G., & Ransohoff, R. M. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.03.003 · Cited by 42 · see citing works
Marques, F., & Sousa, J. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00136 · Cited by 42 · see citing works
Xu, Y., Nygård, M., Kristensson, K., & Bentivoglio, M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.006 · Cited by 41 · see citing works
Braun, J., Kaissling, B., Hir, M. L., & Zenker, W. (1993) · Cell and Tissue Research · doi:10.1007/bf00312822 · Cited by 40 · see citing works
Cell death in the choroid plexus following transient forebrain global ischemia in the rat
Ferrand-Drake, M. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010101)52:1 · Cited by 40 · see citing works
Proliferation of Cultured Mouse Choroid Plexus Epithelial Cells
Barkho, B. Z., & Monuki, E. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121738 · Cited by 39 · see citing works
The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain
Spector, R., & Johanson, C. E. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-3 · Cited by 38 · see citing works
Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress
Xiang, J., Alesi, G. N., Zhou, N., & Keep, R. F. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00518.2011 · Cited by 37 · see citing works
Lazarevic, I., & Engelhardt, B. (2015) · Fluids and Barriers of the CNS · doi:10.1186/s12987-016-0027-0 · Cited by 37 · see citing works
Self-citationSchmitt, C., Strazielle, N., & Ghersi-Egea, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-187 · Cited by 33 · see citing works
Self-citationBarrier mechanisms for neurotransmitter monoamines in the choroid plexus
Lindvall, M. L., Hardebo, J. E., & Owman, C. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06525.x · Cited by 32 · see citing works
Choroid plexus failure in the Kearns-Sayre syndrome
Spector, R., & Johanson, C. E. (2010) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-7-14 · Cited by 32 · see citing works
Smith, D. E., Hu, Y., Shen, H., et al. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.84 · Cited by 31 · see citing works
Quintela, T., Marcelino, H., Deery, M. J., Feret, R., Howard, J., Lilley, K. S., Albuquerque, T., Gonçalves, I., Duarte, A. C., & Santos, C. R. A. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12340 · Cited by 28 · see citing works
Prostaglandin E2metabolism in rat brain: Role of the blood-brain interfaces
Alix, E., Schmitt, C., Strazielle, N., & Ghersi‐Egea, J. (2008) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-5-5 · Cited by 26 · see citing works
Self-citationKhuth, S. T., Strazielle, N., Giraudon, P., Belin, M., & Ghersi‐Egea, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03309.x · Cited by 26 · see citing works
Self-citationVandenhaute, E., Stump-Guthier, C., Losada, M. L., et al. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0257-2 · Cited by 25 · see citing works
Usui, T., Nakazawa, A., Okura, T., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13758 · Cited by 25 · see citing works
Su, P., Zhao, F., Cao, Z., Zhang, J., Aschner, M., & Luo, W. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.05.002 · Cited by 21 · see citing works
Ghersi-Egea, J., Babikian, A., Blondel, S., & Strazielle, N. (2015) · Fluids and Barriers of the CNS · doi:10.1186/s12987-015-0001-2 · Cited by 20 · see citing works
Self-citationHan, H., Kim, S.-G., Lee, M.-G., et al. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.11.1214 · Cited by 13 · see citing works
Proliferative zones in the epithelium of the choroid plexuses of the human embryo brain
Korzhevsky, D. E. (2000) · Neuroscience and Behavioral Physiology · doi:10.1007/bf02462607 · Cited by 12 · see citing works
Virág, J., Haberler, C., Baksa, G., Piurkó, V., Hegedűs, Z., Reiniger, L., Bálint, K., Chocholous, M., Kiss, A., Lotz, G., et al. (2016) · Pathology & Oncology Research · doi:10.1007/s12253-016-0084-3 · Cited by 9 · see citing works
Japp, A. S., Klein‐Hitpaß, L., Denkhaus, D., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw101 · Cited by 6 · see citing works
Ghersi‐Egea, J., & Damkier, H. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803196-4.00002-3 · Cited by 4 · see citing works
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Research works printed but not linked: 1
- Engelhardt B (2001) The choroid plexus in health and disease. Microcopy research and technique, vol 52. Wiley-Liss, New York
Cited by
Sorted by citations
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Thomas, R., Wang, W., & Su, D.-M. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-0173-8 · Cited by 442 · see citing works
Macrophages at CNS interfaces: Ontogeny and function in health and disease
Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0201-x · Cited by 416 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
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Cui, J., Shipley, F. B., Shannon, M. L., Alturkistani, O., Dani, N., Webb, M. D., Sugden, A. U., Andermann, M. L., & Lehtinen, M. K. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.09.020 · Cited by 128 · see citing works
The barrier and interface mechanisms of the brain barrier, and brain drug delivery
Zhang, S., Gan, L., Cao, F., Wang, H., Gong, P., Ma, C., Ren, L., Lin, Y., & Lin, X. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.09.017 · Cited by 129 · see citing works
Enzmann, G., Kargaran, S., & Engelhardt, B. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418794184 · Cited by 119 · see citing works
Self-citationShipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.024 · Cited by 118 · see citing works
Yazdan-Panah, A., Schmidt-Mengin, M., Ricigliano, V. A. G., Soulier, T., Stankoff, B., & Colliot, O. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103368 · Cited by 58 · see citing works
Gomes, I. C., Karmirian, K., Oliveira, J., Pedrosa, C., Rosman, F. C., Chimelli, L., & Rehen, S. (2020) · doi:10.20944/preprints202009.0297.v1 · Cited by 51 · see citing works
- Authors
- Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Basel (CH)
- University of Bern (CH)
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2018-01-24
- Volume
- 135
- Issue
- 3
- Pages
- 337-361
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2787246109
- Cited by
- 436
- References
- 170
- Citations by year
- 2026: 47 · 2025: 60 · 2024: 61 · 2023: 58 · 2022: 61 · 2021: 45 · 2020: 61 · 2019: 28 · 2018: 15
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, other-oa)
- edoc (University of Basel) (submittedVersion)
- Open Access CRIS of the University of Bern
- Funders
- French ministry of Research (ANR-10-IBHU-0003)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A_163088, PDFMP3_137127)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- choroid plexus, blood-CSF barrier, cerebrospinal fluid, cerebrospinal fluid production, cerebrospinal fluid flow, neuroprotection, brain homeostasis, neuroimmune regulation, neuroinflammation, immune cell trafficking, brain development, brain repair, choroid plexus development
- MeSH terms
- Neuroprotection, Animals, Blood-Brain Barrier, Cerebral Ventricles, Cerebrospinal Fluid, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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