The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins
Open accessAbstract
EGFR and Hippo signaling both control growth, and when dysregulated contribute to tumorigenesis. We find that EGFR activates the Hippo pathway transcription factor Yorkie, and demonstrate that Yorkie is required for the influence of EGFR on cell proliferation in Drosophila. EGFR regulates Yorkie through an influence of its Ras-MAPK branch on the Ajuba LIM protein Jub. Jub is epistatic to EGFR and Ras for Yorkie regulation, Jub is subject to MAPK-dependent phosphorylation, and EGFR-Ras-MAPK signaling enhances Jub binding to the Yorkie kinase Warts, and the adaptor protein Salvador. An EGFR-Hippo pathway link is conserved in mammals, as activation of EGFR or RAS activates the Yorkie homologue YAP, and EGFR-RAS-MAPK signaling promotes phosphorylation of the Ajuba family protein WTIP, and also enhances WTIP binding to the Warts and Salvador homologues LATS and WW45. Our observations implicate the Hippo pathway in EGFR-mediated tumorigenesis and identify a molecular link between these pathways.
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Cites
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Metadata
- Authors
- Reddy, B. V. V. G., & Irvine, K. D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 24
- Issue
- 5
- Pages
- 459-471
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1969104713
- Cited by
- 271
- References
- 48
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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