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Cited by 271

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

Open access
Reddy, B.V.V.G., Irvine, Kenneth D.·2013·Developmental Cell
DOI 10.1016/j.devcel.2013.01.020
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Abstract

EGFR and Hippo signaling both control growth, and when dysregulated contribute to tumorigenesis. We find that EGFR activates the Hippo pathway transcription factor Yorkie, and demonstrate that Yorkie is required for the influence of EGFR on cell proliferation in Drosophila. EGFR regulates Yorkie through an influence of its Ras-MAPK branch on the Ajuba LIM protein Jub. Jub is epistatic to EGFR and Ras for Yorkie regulation, Jub is subject to MAPK-dependent phosphorylation, and EGFR-Ras-MAPK signaling enhances Jub binding to the Yorkie kinase Warts, and the adaptor protein Salvador. An EGFR-Hippo pathway link is conserved in mammals, as activation of EGFR or RAS activates the Yorkie homologue YAP, and EGFR-RAS-MAPK signaling promotes phosphorylation of the Ajuba family protein WTIP, and also enhances WTIP binding to the Warts and Salvador homologues LATS and WW45. Our observations implicate the Hippo pathway in EGFR-mediated tumorigenesis and identify a molecular link between these pathways.

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Metadata

Authors
Reddy, B. V. V. G., & Irvine, K. D.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2013-03
Volume
24
Issue
5
Pages
459-471
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2013.01.020
OpenAlex
W1969104713
Cited by
271
References
48
FWCI
15.62
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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