Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, Fa-Xing; Zhao, Bin; Guan, Kun-Liang

doi:10.1016/j.cell.2015.10.044

Cited by 2,206Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer

Hippo pathway in organ size control, tissue homeostasis, and cancer

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Yu, Fa-Xing, Zhao, Bin, Guan, Kun-Liang·2015·Cell

DOI 10.1016/j.cell.2015.10.044PMC PMC4638384

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Abstract

Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.

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Single molecule FISH measurements for Amotl2 demonstrated increased expression of this transcript in Hbo1-depleted hepatocytes.
“Notably, single molecule FISH measurements for Amotl231, a well-known YAP target, demonstrated the increased expression of this transcript in Hbo1-depleted hepatocytes (Figure 4C).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [31]
The cited review does not report single-molecule FISH measurements or increased Amotl2 expression in Hbo1-depleted hepatocytes; the citing sentence points to its own Figure 4C for that result. The review’s “Hippo Pathway in Early Embryonic Development” section mentions AMOT/AMOTL2 depletion in embryos, but does not address this measurement. Searches for Amotl2 and Hbo1-depleted hepatocytes found no supporting passage. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Single cell molecule FISH of YAP target genes Cyr61 and Amotl2 validated their dramatically higher expression in vivo in the absence of HBO1 and their attenuation following HBO1 overexpression.
“Single cell molecule FISH of YAP target genes, Cyr61 and Amotl231, validated their dramatically higher expression in vivo in the absence of HBO1 (Figure 5F, 5G and S5G, and their attenuation following HBO1 overexpression (Figure S5H).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [31]
The citation is attached to the identification of Cyr61 and Amotl2 as YAP target genes, not to the citing authors’ FISH results. The review’s ‘YAP/TAZ and Yki as Major Effectors of Hippo Signaling’ section discusses YAP target genes generally but does not identify Cyr61 or Amotl2 as targets. Searches for those genes and HBO1 found no passage supporting the specific claim; the review mentions AMOTL2 in a different context, as a Hippo-pathway component. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Some hits from earlier CRISPR screens overlap with shared dependencies found in this study, including ELP3, ELP4, PKN2 and RPN1 in H358, EXT1, WWTR1 and SHOC2 in MIAPaCa-2, and PGM3 in the 2D component of the 2D versus 3D screen.
“The “hits” in the earlier papers reveal some shared dependencies with our study (e.g., ELP3, ELP4, PKN2, RPN1 in the H358 screen; EXT1, WWTR1, SHOC2 in MIAPaCa-2 cells, PGM3 in the 2D component of the 2D vs 3D screen; compare with Fig. 1D with References 43,44).”
From Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy (2023) · cites this paper as [43]

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Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry
Benham-Pyle, B. W., Pruitt, B. L., & Nelson, W. J. (2015) · Science · doi:10.1126/science.aaa4559 · Cited by 539 · see citing works
Restriction of intestinal stem cell expansion and the regenerative response by YAP
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The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase
Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525 · see citing works
Self-citation
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
Meng, Z., Moroishi, T., Mottier, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J., Lü, W., Lu, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9357 · Cited by 524 · see citing works
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Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2
Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works
Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded
Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W.-M., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.012 · Cited by 496 · see citing works
The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 494 · see citing works
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programPreprint
Cai, J., Zhang, N., Zheng, Y., de Wilde, R. F., Maitra, A., & Pan, D. (2010) · Genes & Development · doi:10.1101/gad.1978810 · Cited by 491 · see citing works
Role of TAZ as Mediator of Wnt Signaling
Azzolin, L., Zanconato, F., Bresolin, S., Forcato, M., Basso, G., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.027 · Cited by 490 · see citing works
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells
Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I. Y., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 480 · see citing works
The Spectrin-Based Membrane Skeleton and Micron-Scale Organization of the Plasma Membrane
Bennett, V., & Gilligan, D. M. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.000331 · Cited by 470 · see citing works
Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works
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Hippo signaling impedes adult heart regeneration
Heallen, T., Morikawa, Y., Leach, J., Tao, G., Willerson, J. T., Johnson, R. L., & Martin, J. F. (2013) · Development · doi:10.1242/dev.102798 · Cited by 458 · see citing works
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance
Zhou, D., Zhang, Y., Wu, H., Barry, E., Yin, Y., Lawrence, E., Dawson, D. M., Willis, J. E., Markowitz, S. D., Camargo, F. D., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110428108 · Cited by 453 · see citing works
SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila
Goulev, Y., Fauny, J., Gonzalez-Marti, B., Flagiello, D., Silber, J., & Zider, A. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.034 · Cited by 452 · see citing works
Delineation of a Fat tumor suppressor pathway
Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R. G., & Irvine, K. D. (2006) · Nature Genetics · doi:10.1038/ng1887 · Cited by 432 · see citing works
Modulating F‐actin organization induces organ growth by affecting the Hippo pathway
Sansores-García, L., Bossuyt, W., Wada, K., Yonemura, S., Tao, C., Sasaki, H., & Halder, G. A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.157 · Cited by 430 · see citing works
Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65
Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429 · see citing works
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419 · see citing works
Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos
Hirate, Y., Hirahara, S., Inoue, K., Suzuki, A., Alarcón, V. B., Akimoto, K., Hirai, T., Hara, T., Adachi, M., Chida, K., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.014 · Cited by 418 · see citing works
Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional TargetsCyr61andCTGF
Lai, D., Ho, K. C., Hao, Y., & Yang, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2711 · Cited by 416 · see citing works
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005465 · Cited by 414 · see citing works
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
Enzo, E., Santinon, G., Pocaterra, A., Aragona, M., Bresolin, S., Forcato, M., Grifoni, D., Pession, A., Zanconato, F., Guzzo, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490379 · Cited by 414 · see citing works
In vivo regulation of Yorkie phosphorylation and localization
Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 404 · see citing works
Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model
Lin, Z., von Gise, A., Zhou, P., Gu, F., Ma, Q., Jiang, J., Yau, A. L., Buck, J. N., Gouin, K. A., van Gorp, P. R. R., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.303632 · Cited by 403 · see citing works
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402 · see citing works
Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma
Tanas, M. R., Sboner, A., Oliveira, A. M., Erickson‐Johnson, M. R., Hespelt, J., Hanwright, P. J., Flanagan, J., Luo, Y., Fenwick, K., Natrajan, R., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002409 · Cited by 399 · see citing works
The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila
Thompson, B. J., & Cohen, S. M. (2006) · Cell · doi:10.1016/j.cell.2006.07.013 · Cited by 398 · see citing works
YAP regulates neural progenitor cell number via the TEA domain transcription factorPreprint
Cao, X., Pfaff, S. L., & Gage, F. H. (2008) · Genes & Development · doi:10.1101/gad.1726608 · Cited by 398 · see citing works
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisPreprint
Jia, J., Zhang, W., Wang, B., Trinko, R., & Jiang, J. (2003) · Genes & Development · doi:10.1101/gad.1134003 · Cited by 392 · see citing works
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
Ota, M., & Sasaki, H. (2008) · Development · doi:10.1242/dev.027151 · Cited by 391 · see citing works
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumorsPreprint
McClatchey, A. I., Saotome, I., Mercer, K. L., Crowley, D. G., Gusella, J. F., Bronson, R. T., & Jacks, T. (1998) · Genes & Development · doi:10.1101/gad.12.8.1121 · Cited by 388 · see citing works
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferationPreprint
Fernández-L, A., Northcott, P. A., Dalton, J., Fraga, C. H., Ellison, D. W., Angers, S., Taylor, M. D., & Kenney, A. M. (2009) · Genes & Development · doi:10.1101/gad.1824509 · Cited by 378 · see citing works
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasisPreprint
Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F., Karin, M., Pan, D., et al. (2015) · Genes & Development · doi:10.1101/gad.262816.115 · Cited by 367 · see citing works
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Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
Zhang, W., Nandakumar, N., Shi, Y., Manzano, M., Smith, A., Graham, G., Gupta, S., Vietsch, E. E., Laughlin, S. Z., Wadhwa, M., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005049 · Cited by 360 · see citing works
Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila
Kango‐Singh, M., Nolo, R. M., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. A. (2002) · Development · doi:10.1242/dev.00168 · Cited by 347 · see citing works
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
Praskova, M. D., KHOKLATCHEV, A., Ortiz-Vega, S., & Avruch, J. (2004) · Biochemical Journal · doi:10.1042/bj20040025 · Cited by 342 · see citing works
Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex
Rauskolb, C., Sun, S., Sun, G., Pan, Y., & Irvine, K. D. (2014) · Cell · doi:10.1016/j.cell.2014.05.035 · Cited by 339 · see citing works
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
Fan, R., Kim, N., & Gumbiner, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216462110 · Cited by 339 · see citing works
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiationPreprint
Yu, F., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z.-C., & Guan, K. (2013) · Genes & Development · doi:10.1101/gad.219402.113 · Cited by 337 · see citing works
Self-citation
Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer
Mori, M., Triboulet, R., Mohseni, M., Schlegelmilch, K., Shrestha, K., Camargo, F. D., & Gregory, R. I. (2014) · Cell · doi:10.1016/j.cell.2013.12.043 · Cited by 335 · see citing works
Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
Touil, Y. S., Igoudjil, W., Corvaisier, M., Dessein, A., Vandomme, J., Monté, D., Stechly, L., Skrypek, N., Langlois, C., Grard, G., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1854 · Cited by 333 · see citing works
The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size
Willecke, M., Hamaratoǧlu, F., Kango‐Singh, M., Udan, R. S., Chen, C., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.005 · Cited by 329 · see citing works
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
Chen, L., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., & Pan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004279107 · Cited by 320 · see citing works
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 320 · see citing works
Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
DeRan, M., Yang, J., Shen, C.-H., Peters, E. C., Fitamant, J., Chan, P., Hsieh, M., Zhu, S., Asara, J. M., Zheng, B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.036 · Cited by 316 · cited 8× · see citing works
“Under energy deprivation, such as glucose starvation, the AMPK-activated protein kinase (AMPK) can directly phosphorylate YAP at serine 61 (S61) and serine 94 (S94) (Mo et al., 2015; Wang et al., 2015).”
Influential
Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T., & Jiang, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012759107 · Cited by 316 · see citing works
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., Zhang, X., Zhang, F., Chen, H., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319190110 · Cited by 315 · see citing works
Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway
Bennett, F. C., & Harvey, K. F. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.045 · Cited by 314 · see citing works
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Development · doi:10.1242/dev.060483 · Cited by 314 · see citing works
Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded
Robinson, B. S., Huang, J., Hong, Y., & Moberg, K. H. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.019 · Cited by 312 · see citing works
Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers
Cottini, F., Hideshima, T., Xu, C., Sattler, M., Dori, M., Agnelli, L., ten Hacken, E., Bertilaccio, M. T. S., Antonini, E., Neri, A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3562 · Cited by 310 · see citing works
The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration
Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 307 · see citing works
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
Chen, C., Gajewski, K. M., Hamaratoǧlu, F., Bossuyt, W., Sansores-García, L., Tao, C., & Halder, G. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004060107 · Cited by 303 · see citing works
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
Zhang, W., Gao, Y., Li, P., Shi, Z., Guo, T., Li, F., Han, X., Feng, Y., Zheng, C., Wang, Z., et al. (2014) · Cell Research · doi:10.1038/cr.2014.10 · Cited by 300 · see citing works
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
Hossain, Z., Ali, S. M., Ko, H. L., Xu, J., Ng, C. P., Guo, K., Qi, Z., Ponniah, S., Hong, W., & Hunziker, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605266104 · Cited by 297 · see citing works
Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development
Reginensi, A., Scott, R. P., Gregorieff, A., Bagherie-Lachidan, M., Chung, C., Lim, D., Pawson, T. J., Wrana, J. L., & McNeill, H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003380 · Cited by 295 · see citing works
A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
Mohseni, M., Sun, J., Lau, A., Curtis, S., Goldsmith, J., Fox, V. L., Wei, C., Frazier, M., Samson, O., Wong, K.-K., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2884 · Cited by 294 · see citing works
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2007 · Cited by 294 · see citing works
Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
Fernández, B. G., Gaspar, P., Brás‐Pereira, C., Jezowska, B., Rebelo, S. P., & Janody, F. (2011) · Development · doi:10.1242/dev.063545 · Cited by 293 · see citing works
The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway
Silva, E., Tsatskis, Y., Gardano, L., Tapon, N., & McNeill, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.004 · Cited by 290 · see citing works
Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ
Kim, M., Kim, T., Johnson, R. L., & Lim, D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.015 · Cited by 285 · see citing works
Regulation of the Hippo–YAP pathway by protease-activated receptors (PARs)Preprint
Mo, J., Yu, F., Gong, R., Brown, J. H., & Guan, K. (2012) · Genes & Development · doi:10.1101/gad.197582.112 · Cited by 282 · see citing works
Self-citation
The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression
Koontz, L. M., Liu‐Chittenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S., & Pan, D. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.021 · Cited by 282 · see citing works
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation
Callus, B. A., Verhagen, A. M., & Vaux, D. L. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05427.x · Cited by 276 · see citing works
Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins
Reddy, B. V. V. G., & Irvine, K. D. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.020 · Cited by 271 · see citing works
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269 · see citing works
The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway
Nolo, R. M., Morrison, C. M., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.057 · Cited by 266 · see citing works
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
Ma, B., Chen, Y., Chen, L., Cheng, H., Mu, C., Li, J., Gao, R., Zhou, C., Cao, L., Liu, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3073 · Cited by 266 · see citing works
Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases
Flucke, U. E., Vogels, R. J., Somerhausen, N. D. S. A., Creytens, D., Riedl, R. G., van Gorp, J. M., Milne, A. N., Huysentruyt, C. J. R., Verdijk, M. A. J., van Asseldonk, M. J. M. D., et al. (2014) · Diagnostic Pathology · doi:10.1186/1746-1596-9-131 · Cited by 266 · see citing works
YAP is essential for tissue tension to ensure vertebrate 3D body shape
Porazinski, S. R., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, G., Osada, Y., et al. (2015) · Nature · doi:10.1038/nature14215 · Cited by 260 · see citing works
LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
Murakami, H., Mizuno, T., Taniguchi, T., Fujii, M., Ishiguro, F., Fukui, T., Akatsuka, S., Horio, Y., Hida, T., Kondo, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2164 · Cited by 260 · see citing works
Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury
Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436311 · Cited by 249 · see citing works
Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway
Boggiano, J. C., Vanderzalm, P. J., & Fehon, R. G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.028 · Cited by 249 · see citing works
The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors
Mahoney, J. E., Mori, M., Szymaniak, A. D., Varelas, X., & Cardoso, W. V. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.003 · Cited by 248 · see citing works
Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP
Miller, E., Yang, J., DeRan, M., Wu, C., Su, A. I., Bonamy, G. M. C., Liu, J., Peters, E. C., & Wu, X. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.005 · Cited by 247 · see citing works
Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling
Codelia, V. A., Sun, G., & Irvine, K. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.034 · Cited by 233 · see citing works
Estrogen regulates Hippo signaling via GPER in breast cancer
Zhou, X., Wang, S., Wang, Z., Feng, X., Liu, P., Lv, X.-B., Li, F., Yu, F.-X., Sun, Y., Yuan, H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79573 · Cited by 232 · see citing works
Self-citation
The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway
Poon, C. L. C., Lin, J. I., Zhang, X., & Harvey, K. F. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.012 · Cited by 227 · see citing works
A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisPreprint
Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A., & Pan, D. (2014) · Genes & Development · doi:10.1101/gad.233676.113 · Cited by 220 · see citing works
cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
Kim, M., Kim, M., Lee, S., Kuninaka, S., Saya, H., Lee, H., Lee, S., & Lim, D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.102 · Cited by 217 · see citing works
The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification
Cockburn, K., Biechele, S., Garner, J., & Rossant, J. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.044 · Cited by 213 · see citing works
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade
Zheng, Y., Wang, W., Liu, B., Deng, H., Uster, E., & Pan, D. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.08.014 · Cited by 210 · see citing works
Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung
Lange, A. W., Sridharan, A., Xu, Y. J., Stripp, B. R., Perl, A. T., & Whitsett, J. A. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju046 · Cited by 208 · see citing works
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
Liang, N., Zhang, C., Dill, P., Panasyuk, G., Pion, D., Koka, V., Gallazzini, M., Olson, E. N., Lam, H., Henske, E. P., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140341 · Cited by 205 · see citing works
Shear Stress Induced by an Interstitial Level of Slow Flow Increases the Osteogenic Differentiation of Mesenchymal Stem Cells through TAZ Activation
Kim, K. M., Choi, Y. J., Hwang, J.-H., Kim, A. R., Cho, H. J., Hwang, E. S., Park, J. Y., Lee, S.-H., & Hong, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092427 · Cited by 198 · see citing works
A crucial role of WW45 in developing epithelial tissues in the mouse
Lee, J., Kim, T., Yang, T.-H., Koo, B., Oh, S.-P., Lee, K., Oh, H.-J., Lee, S., Kong, Y., Kim, J., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.63 · Cited by 195 · see citing works
The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells
Judson, R. N., Tremblay, A. M., Knopp, P., White, R. B., Urcia, R., De Bari, C., Zammit, P. S., Camargo, F. D., & Wackerhage, H. (2012) · Journal of Cell Science · doi:10.1242/jcs.109546 · Cited by 190 · see citing works
TAZ Promotes PC2 Degradation through a SCF β-Trcp E3 Ligase Complex
Tian, Y., Kolb, R. J., Hong, J.-H., Carroll, J., Li, D., You, J., Bronson, R. T., Yaffe, M. B., Zhou, J., & Benjamin, T. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00254-07 · Cited by 188 · see citing works
The Hippo Signaling Pathway Interactome
Kwon, Y. V., Vinayagam, A., Sun, X., Dephoure, N., Gygi, S. P., Hong, P., & Perrimon, N. (2013) · Science · doi:10.1126/science.1243971 · Cited by 178 · see citing works
β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesisPreprint
Cai, J., Maitra, A., Anders, R. A., Taketo, M. M., & Pan, D. (2015) · Genes & Development · doi:10.1101/gad.264515.115 · Cited by 175 · see citing works
C11ORF95-RELA FUSIONS DRIVE ONCOGENIC NF-KB SIGNALING IN EPENDYMOMA
Gilbertson, R. J., Parker, M. D., Mohankumar, K. M., Punchihewa, C., Weinlich, R., Dalton, J. D., Li, Y., Lee, R. P., Tatevossian, R., Phoenix, T. N., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou206.57 · Cited by 173 · see citing works
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
Bao, Y., Nakagawa, K., Yang, Z. H., Ikeda, M., Withanage, K., Ishigami‐Yuasa, M., Okuno, Y., Hata, S., Nishina, H., & Hata, Y. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr063 · Cited by 172 · see citing works
Yes-associated protein regulates the hepatic response after bile duct ligation
Bai, H., Zhang, N., Xu, Y., Chen, Q., Khan, M. A., Potter, J. J., Nayar, S. K., Cornish, T. C., Alpini, G. D., Bronk, S. F., et al. (2012) · Hepatology · doi:10.1002/hep.25769 · Cited by 168 · see citing works
The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size
Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F., & Gregorevic, P. (2015) · Nature Communications · doi:10.1038/ncomms7048 · Cited by 164 · see citing works
The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition
Huang, W., Lv, X., Liu, C., Zha, Z., Zhang, H., Jiang, Y., Xiong, Y., Lei, Q., & Guan, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382036 · Cited by 161 · see citing works
Self-citation
Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
Grijalva, J., Huizenga, M. N., Mueller, K. A., Rodriguez, S., Brazzo, J. A., Camargo, F. D., Sadri‐Vakili, G., & Vakili, K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2014 · Cited by 159 · see citing works
The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment
Skibinski, A., Breindel, J. L., Prat, A., Galván, P., Smith, E., Rolfs, A., Gupta, P. B., LaBaer, J., & Kuperwasser, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.038 · Cited by 159 · see citing works
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
Fernández-L, A., Squatrito, M., Northcott, P. A., Awan, A., Holland, E. C., Taylor, M. D., Nahle, Z. A., & Kenney, A. M. (2011) · Oncogene · doi:10.1038/onc.2011.379 · Cited by 157 · see citing works
Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
Gao, T., Zhou, D., Yang, C., Singh, T., Penzo‐Méndez, A., Maddipati, R., Tzatsos, A., Bardeesy, N. M., Avruch, J., & Stanger, B. Z. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.037 · Cited by 151 · see citing works
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S. O., Dong, Y., Tokuda, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63735 · Cited by 149 · see citing works
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
Iglesias‐Bartolomé, R., Torres, D., Marone, R., Feng, X., Martı́n, D., Simaan, M., Chen, M., Weinstein, L. S., Taylor, S. S., Molinolo, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3164 · Cited by 147 · see citing works
Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
Oh, H., Slattery, M., Ma, L., Crofts, A., White, K. P., Mann, R. S., & Irvine, K. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.008 · Cited by 145 · see citing works
The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila
Li, Q., Li, S., Mana‐Capelli, S., Flach, R. J. R., Danai, L. V., Amcheslavsky, A., Nie, Y., Kaneko, S., Yao, X., Chen, X., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.012 · Cited by 142 · see citing works
Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
Straßburger, K., Tiebe, M., Pinna, F., Breuhahn, K., & Teleman, A. A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.05.008 · Cited by 141 · see citing works
Inhibition of RHO–ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst
Kono, K., Tamashiro, D. A. A., & Alarcón, V. B. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.06.023 · Cited by 140 · see citing works
Hippo Pathway Regulation of Gastrointestinal Tissues
Yu, F., Meng, Z., Plouffe, S. W., & Guan, K. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071733 · Cited by 138 · see citing works
Self-citation
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAPPreprint
Chen, Q., Zhang, N., Xie, R., Wang, W., Cai, J., Choi, K.-S., David, K. K., Huang, B., Yabuta, N., Nojima, H., et al. (2015) · Genes & Development · doi:10.1101/gad.264234.115 · Cited by 136 · see citing works
The Spectrin cytoskeleton regulates the Hippo signalling pathway
Fletcher, G., Elbediwy, A., Khanal, I., Ribeiro, P. S., Tapon, N., & Thompson, B. J. (2015) · The EMBO Journal · doi:10.15252/embj.201489642 · Cited by 135 · see citing works
Hippo Signaling Regulates Pancreas Development through Inactivation of Yap
George, N. M., Day, C. E., Boerner, B. P., Johnson, R. L., & Sarvetnick, N. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01034-12 · Cited by 135 · see citing works
A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)
Fossdal, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh106 · Cited by 132 · see citing works
The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense
Wu, H., Xiao, Y., Zhang, S., Ji, S., Wei, L., Fan, F., Geng, J., Tian, J., Sun, X., Qin, F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.020 · Cited by 128 · see citing works
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression
Gao, Y., Zhang, W., Han, X., Li, F., Wang, X., Wang, R., Fang, Z., Tong, X., Yao, S., Li, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms5629 · Cited by 121 · see citing works
Self-citation
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype
Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget · doi:10.18632/oncotarget.2997 · Cited by 119 · see citing works
Regulation of the Hippo pathway and implications for anticancer drug development
Park, H. W., & Guan, K. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.08.006 · Cited by 117 · see citing works
Self-citation
A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity
Guo, T., Lu, Y., Li, P., Yin, M.-X., Lv, D., Zhang, W., Wang, H., Zhou, Z., Ji, H., Zhao, Y., et al. (2013) · Cell Research · doi:10.1038/cr.2013.120 · Cited by 116 · see citing works
Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing
Miyanaga, A., Masuda, M., Tsuta, K., Kawasaki, K., Nakamura, Y., Sakuma, T., Asamura, H., Gemma, A., & Yamada, T. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000493 · Cited by 115 · see citing works
Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
Deng, H., Wang, W., Yu, J., Zheng, Y., Qing, Y., & Pan, D. (2015) · eLife · doi:10.7554/elife.06567 · Cited by 113 · see citing works
Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects
Williamson, K. A., Rainger, J., Floyd, J. A. B., Ansari, M., Meynert, A. M., Aldridge, K. V., Rainger, J. K., Anderson, C. A., Moore, A. T., Hurles, M. E., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.001 · Cited by 112 · see citing works
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiationPreprint
Lorthongpanich, C., Messerschmidt, D. M., Chan, S. W., Hong, W., Knowles, B. B., & Solter, D. (2013) · Genes & Development · doi:10.1101/gad.219618.113 · Cited by 109 · see citing works
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
Wehr, M. C., Holder, M. V., Gailite, I., Saunders, R. E., Maile, T. M., Ciirdaeva, E., Instrell, R., Jiang, M., Howell, M. T., Rossner, M. J., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2658 · Cited by 108 · see citing works
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
Lavado, A., He, Y. Y., Paré, J., Neale, G. A. M., Olson, E. N., Giovannini, M., & Cao, X. (2013) · Development · doi:10.1242/dev.096537 · Cited by 108 · see citing works
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
Tyler, D. M., & Baker, N. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.004 · Cited by 105 · see citing works
Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice
Mitani, A., Nagase, T., Fukuchi, K., Aburatani, H., Makita, R., & Kurihara, H. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200812-1827oc · Cited by 105 · see citing works
A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis
Shen, S., Guo, X., Yan, H., Lu, Y., Ji, X., Li, L., Liang, T., Zhou, D., Feng, X., Zhao, J. C., et al. (2015) · Cell Research · doi:10.1038/cr.2015.98 · Cited by 103 · see citing works
Self-citation
The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7
Chaulk, S. G., Lattanzi, V. J., Hiemer, S. E., Fahlman, R. P., & Varelas, X. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.529362 · Cited by 101 · see citing works
Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
Matakatsu, H., & Blair, S. S. (2012) · Development · doi:10.1242/dev.070367 · Cited by 101 · see citing works
The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway
Yue, T., Tian, A., & Jiang, J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.011 · Cited by 97 · see citing works
The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes
Wennmann, D. O., Vollenbröker, B., Eckart, A. K., Bonse, J., Erdmann, F., Wolters, D. A., Schenk, L. K., Schulze, U., Kremerskothen, J., Weide, T., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.476 · Cited by 94 · see citing works
R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability
Chen, H., Yu, S., Ho, B., Su, K., Hsu, Y., Chang, C.-S., Li, Y.-C., Yang, S., Hsu, P.-Y., Ho, H. H., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.3590 · Cited by 94 · see citing works
Opposite Feedbacks in the Hippo Pathway for Growth Control and Neural Fate
Jukam, D., Xie, B., Rister, J., Terrell, D., Charlton-Perkins, M. A., Pistillo, D., Gebelein, B. A., Desplan, C., & Cook, T. A. (2013) · Science · doi:10.1126/science.1238016 · Cited by 88 · see citing works
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
Sekido, Y. (2011) · Pathology International · doi:10.1111/j.1440-1827.2011.02666.x · Cited by 87 · see citing works
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration
Mi, W., Lin, Q., Childress, C., Sudol, M., Robishaw, J. D., Berlot, C. H., Shabahang, M. M., & Yang, W. (2014) · Oncogene · doi:10.1038/onc.2014.251 · Cited by 86 · see citing works

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Mechanisms of physiological and pathological cardiac hypertrophy
Nakamura, M., & Sadoshima, J. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0007-y · Cited by 1,662 · see citing works
Mechanobiology of YAP and TAZ in physiology and disease
Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works
The Hippo Pathway: Biology and Pathophysiology
Ma, S., Meng, Z., Chen, R., & Guan, K.-L. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111829 · Cited by 1,387 · see citing works
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Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
Clara, J., Monge, C., Yang, Y., & Takebe, N. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0293-2 · Cited by 752 · see citing works
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
Tao, S., Yuan, T., Zhang, Y.-L., Yin, W., Guo, S., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.17133 · Cited by 734 · see citing works
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow
Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 666 · see citing works
Neural tube closure: cellular, molecular and biomechanical mechanisms
Nikolopoulou, E., Galea, G. L., Rolo, A., Greene, N. D. E., & Copp, A. J. (2017) · Development · doi:10.1242/dev.145904 · Cited by 529 · see citing works
Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K.-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.001 · Cited by 500 · see citing works
The Hippo Signaling Network and Its Biological Functions
Misra, J. R., & Irvine, K. D. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031621 · Cited by 496 · see citing works
Interplay between YAP/TAZ and Metabolism
Koo, J. H., & Guan, K. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.010 · Cited by 468 · see citing works
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Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)
Katoh, M. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4129 · Cited by 467 · see citing works
Circuit Design Features of a Stable Two-Cell System
Zhou, X., Franklin, R. A., Adler, M., Jacox, J. B., Bailis, W., Shyer, J. A., Flavell, R. A., Mayo, A., Alon, U., & Medzhitov, R. (2018) · Cell · doi:10.1016/j.cell.2018.01.015 · Cited by 430 · see citing works
The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
Moroishi, T., Hayashi, T., Pan, W., Fujita, Y., Holt, M. V., Qin, J., Carson, D. A., & Guan, K. (2016) · Cell · doi:10.1016/j.cell.2016.11.005 · Cited by 435 · see citing works
Self-citation
Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413 · see citing works
YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation
Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93825 · Cited by 402 · see citing works
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy
Bertero, T., Oldham, W. M., Grasset, E. M., Bourget, I., Boulter, E., Pisano, S., Hofman, P., Bellvert, F., Meneguzzi, G., Bulavin, D. V., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.012 · Cited by 393 · see citing works
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Fan, F., He, Z., Kong, L., Chen, Q., Yuan, Q., Zhang, S., Ye, J., Liu, H., Sun, X., Geng, J., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf2304 · Cited by 385 · see citing works
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC
Jin, D., Guo, J., Wu, Y., Yang, L., Wang, X., Du, J., Dai, J., Chen, W., Gong, K., Miao, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01161-1 · Cited by 344 · see citing works
Novel Insights into Mesothelioma Biology and Implications for Therapy
Yap, T. A., Aerts, J. G., Popat, S., & Fennell, D. A. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.42 · Cited by 324 · see citing works
Drug resistance and Cancer stem cells
Li, Y., Wang, Z., Ajani, J. A., & Song, S. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-020-00627-5 · Cited by 334 · see citing works
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation
Deng, Y.-J., Lu, J., Li, W., Wu, A.-L., Zhang, X., Tong, W.-X., Ho, K., Qin, L., Song, H., & Mak, K. K. (2018) · Nature Communications · doi:10.1038/s41467-018-07022-2 · Cited by 305 · see citing works
Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
Tanasa, M. P., Renna, M., Park, S. J., Menzies, F. M., Ricketts, T., Füllgrabe, J., Ashkenazi, A., Frake, R. A., Carnicer‐Lombarte, A., Bento, C. F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05388-x · Cited by 318 · see citing works
Lineage specification in the mouse preimplantation embryo
Chazaud, C., & Yamanaka, Y. (2016) · Development · doi:10.1242/dev.128314 · Cited by 317 · see citing works
Drosophila melanogaster: A Model Organism to Study Cancer
Mirzoyan, Z., Sollazzo, M., Allocca, M., Valenza, A., Grifoni, D., & Bellosta, P. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00051 · Cited by 251 · see citing works
Glycogen accumulation and phase separation drives liver tumor initiation
Liu, Q., Li, J., Zhang, W., Xiao, C., Zhang, S., Nian, C., Li, J., Su, D., Chen, L., Zhao, Q. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.001 · Cited by 312 · see citing works
The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
van Rensburg, H. J. J., Azad, T., Ling, M., Hao, Y., Snetsinger, B., Khanal, P., Minassian, L. M., Graham, C. H., Rauh, M. J., & Yang, X. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3139 · Cited by 307 · see citing works
Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription
Chen, Q., Wang, H., Li, Z., Li, F., Liang, L., Zou, Y., Shen, H., Li, J., Xia, Y., Cheng, Z., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.027 · Cited by 295 · see citing works
Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint
Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 283 · see citing works
Self-citation
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
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Authors: Yu, F.-X., Zhao, B., & Guan, K.-L.
Affiliations: Fudan University (CN)
Zhejiang University (CN)
University of California San Diego (US)
Corresponding author: Yu, Fa-Xing
Guan, Kun-Liang
ORCID: Yu, Fa-Xing
Zhao, Bin
Guan, Kun-Liang
Venue: Cell
Publisher: Elsevier BV
Published: 2015-11
Volume: 163
Issue: 4
Pages: 811-828
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2015.10.044
PMC: PMC4638384
OpenAlex: W2148056172
Cited by: 2,206
References: 217
Citations by year: 2026: 132 · 2025: 165 · 2024: 214 · 2023: 222 · 2022: 251 · 2021: 260 · 2020: 270 · 2019: 212 · 2018: 222 · 2017: 159 · 2016: 93 · 2015: 1 · 2014: 1
FWCI: 15.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (5p50dk039255-20)
National Eye Institute (R01EY022611, EY022611)
National Cancer Institute (R35CA196878, CA132809, R01CA108941, R01CA132809, CA196878)
National Institute of General Medical Sciences (GM-51586, R01GM051586)
National Institute of Diabetes and Digestive and Kidney Diseases (P50-DK039255)
National Institute of Dental and Craniofacial Research (DE015964, R01DE015964)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: Hippo signaling pathway, organ size control, tissue homeostasis, YAP, TAZ, transcriptional coactivator, cell proliferation, apoptosis, stemness, cell-cell contact, cell polarity, mechanical cues, G protein-coupled receptors, cellular energy status, carcinogenesis, cancer therapy targets
MeSH terms: Animals, Cell Physiological Phenomena, Homeostasis, Humans, Neoplasms, Organ Size, Signal Transduction, Protein Serine-Threonine Kinases

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Hippo pathway in organ size control, tissue homeostasis, and cancer

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