A GPCR Handles Bacterial Sensing in Chemotaxis and Phagocytosis
Open accessAbstract
In this issue of Developmental Cell, Pan et al. (2016) identified in cells of the social amoeba Dictyostelium a G protein-coupled receptor (GPCR) that recognizes a chemoattractant secreted by bacteria. This work uncovers a mechanism by which a single GPCR mediates pseudopod extension during cell migration and bacterial engulfment.
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GPCRs like PAR-2 recognize chemoattractants secreted by microorganisms, enhancing phagocytic capacity through remodeling of the actin cytoskeleton.
“In fact, GPCRs like PAR-2 were shown to recognize chemoattractants secreted by microorganisms, enhancing the phagocytic capacity through the remodeling of the actin cytoskeleton [ 75 , 76 , 77 ].”
From Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing (2023) · cites this paper as [75]
The Summary (page not provided) describes a bacterial chemoattractant, folic acid, acting through the GPCR fAR1 in Dictyostelium; it also reports fAR1-dependent actin polymerization and bacterial engulfment. It does not identify PAR-2 as the receptor or establish this mechanism for PAR-2. (LLM, conf=0.88)
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The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.
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Bento-Lopes, L., Cabaço, L. C., Charneca, J., Neto, M. V., Seabra, M. C., & Barral, D. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411289 · Cited by 114 · see citing works
The excitable signal transduction networks: movers and shapers of eukaryotic cell migration
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Bosch, D. E., Jeck, W. R., & Siderovski, D. P. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102167 · Cited by 4 · see citing works
- Authors
- Senoo, H., Sesaki, H., & Iijima, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Iijima, Miho
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 36
- Issue
- 4
- Pages
- 354-356
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC5378551
- OpenAlex
- W2286261215
- Cited by
- 4
- References
- 10
- Citations by year
- 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM084015)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- G protein-coupled receptors, Dictyostelium, bacterial sensing, chemotaxis, phagocytosis, chemoattractants, pseudopod extension, cell migration, social amoebae
- MeSH terms
- Animals, Chemotaxis, Dictyostelium, Folic Acid, Phagocytosis, Receptors, G-Protein-Coupled
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