The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the disruption of myelin homeostasis adversely contributes to many neurological disorders, such as multiple sclerosis, leukodystrophies, and dementia.6,7,8,9,10”
From Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function (2025) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507 · cited 4×
“In more mature cells - 4 days following T3 treatment - we did observe significantly decreased Myrf levels, a pattern similar to other myelin component genes (Figure S3K).”
InfluentialSamanta, J., & Kessler, J. A. (2004) · Development · doi:10.1242/dev.01273 · Cited by 361
Characterizing longitudinal white matter development during early childhood
Dean, D. C., O’Muircheartaigh, J., Dirks, H., Waskiewicz, N., Walker, L., Doernberg, E., Piryatinsky, I., & Deoni, S. C. L. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0763-3 · Cited by 174
Gabriele, M., Vulto-van Silfhout, A. T., Germain, P.-L., Vitriolo, A., Kumar, R., Douglas, E., Haan, E., Kosaki, K., Takenouchi, T., Rauch, A., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.05.006 · Cited by 163
Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
Heng, M. Y., Lin, S.-T., Verret, L., Huang, Y., Kamiya, S., Padiath, Q. S., Tong, Y., Palop, J. J., Huang, E. J., Ptácχek, L. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66737 · Cited by 78
Zolova, O. E., & Wight, P. A. (2011) · ASN Neuro · doi:10.1042/an20110021 · Cited by 15
Flagged first, then by citations
Research works printed but not linked: 44
- Aguilo, 2017, THAP1: role in mouse embryonic stem cell survival and differentiation, Stem Cell Rep., 10.1016/j.stemcr.2017.04.032 · DOI
- Auerbach, 2013, Relating genes to function: identifying enriched transcription factors using the ENCODE ChIP-Seq significance tool, Bioinformatics, 29, 1922, 10.1093/bioinformatics/btt316 · DOI
- Berndt, 2001, The transcriptional regulator Yin Yang 1 activates the myelin PLP gene, J. Neurochem., 77, 935, 10.1046/j.1471-4159.2001.00307.x · DOI
- Blanchard, 2011, DYT6 dystonia: review of the literature and creation of the UMD Locus-Specific Database (LSDB) for mutations in the THAP1 gene, Hum. Mutat., 32, 1213, 10.1002/humu.21564 · DOI
- Bonilha, 2007, Structural white matter abnormalities in patients with idiopathic dystonia, Mov. Disord., 22, 1110, 10.1002/mds.21295 · DOI
- Campagne, 2010, Structural determinants of specific DNA-recognition by the THAP zinc finger, Nucleic Acids Res., 38, 3466, 10.1093/nar/gkq053 · DOI
- Carbon, 2011, Impaired sequence learning in dystonia mutation carriers: a genotypic effect, Brain, 134, 1416, 10.1093/brain/awr060 · DOI
- Cayrol, 2007, The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes, Blood, 109, 584, 10.1182/blood-2006-03-012013 · DOI
- Cheng, 2012, Subcellular distribution of THAP1 and alterations in the microstructure of brain white matter in DYT6 dystonia, Parkinsonism Relat. Disord., 18, 978, 10.1016/j.parkreldis.2012.05.008 · DOI
- Connors, 2008, Fetal mechanisms in neurodevelopmental disorders, Pediatr. Neurol., 38, 163, 10.1016/j.pediatrneurol.2007.10.009 · DOI
- Dauer, 2014, Inherited isolated dystonia: clinical genetics and gene function, Neurotherapeutics, 11, 807, 10.1007/s13311-014-0297-7 · DOI
- Dugas, 2013, Purification of oligodendrocyte precursor cells from rat cortices by immunopanning, Cold Spring Harb. Protoc., 2013, 745, 10.1101/pdb.prot070862 · DOI
- Fuchs, 2009, Mutations in the THAP1 gene are responsible for DYT6 primary torsion dystonia, Nat. Genet., 41, 286, 10.1038/ng.304 · DOI
- Gotea, 2008, DiRE: identifying distant regulatory elements of co-expressed genes, Nucleic Acids Res., 36, W133, 10.1093/nar/gkn300 · DOI
- Guo, 2012, Isolation of multipotent neural stem or progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse, Nat. Protoc., 7, 2005, 10.1038/nprot.2012.123 · DOI
- He, 2007, The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation, Neuron, 55, 217, 10.1016/j.neuron.2007.06.029 · DOI
- Hoftman, 2011, Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia, Schizophr. Bull., 37, 493, 10.1093/schbul/sbr029 · DOI
- Houlden, 2010, THAP1 mutations (DYT6) are an additional cause of early-onset dystonia, Neurology, 74, 846, 10.1212/WNL.0b013e3181d5276d · DOI
- Jessen, 2008, Negative regulation of myelination: relevance for development, injury, and demyelinating disease, Glia, 56, 1552, 10.1002/glia.20761 · DOI
- Kheradpour, 2014, Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments, Nucleic Acids Res., 42, 2976, 10.1093/nar/gkt1249 · DOI
- Kondo, 2000, The Id4 HLH protein and the timing of oligodendrocyte differentiation, EMBO J., 19, 1998, 10.1093/emboj/19.9.1998 · DOI
- Liang, 2014, TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration, J. Clin. Invest., 124, 3080, 10.1172/JCI72830 · DOI
- Mazars, 2010, The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias, J. Biol. Chem., 285, 13364, 10.1074/jbc.M109.072579 · DOI
- Ortiz-Virumbrales, 2014, Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions, Acta Neuropathol. Commun., 2, 139, 10.1186/s40478-014-0139-1 · DOI
- Ozelius, 2011, Genetic and clinical features of primary torsion dystonia, Neurobiol. Dis., 42, 127, 10.1016/j.nbd.2010.12.012 · DOI
- Pappas, 2014, Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits, Curr. Top. Dev. Biol., 109, 97, 10.1016/B978-0-12-397920-9.00001-9 · DOI
- Pappas, 2015, Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons, Elife, 4, e08352, 10.7554/eLife.08352 · DOI
- Ramdhani, 2013, Primary dystonia: conceptualizing the disorder through a structural brain imaging lens, Tremor Other Hyperkinet. Mov. (N Y), 3
- Roussigne, 2003, THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies, Oncogene, 22, 2432, 10.1038/sj.onc.1206271 · DOI
- Ruiz, 2015, Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia, Hum. Mol. Genet., 24, 7159, 10.1093/hmg/ddv384 · DOI
- Sabogal, 2010, THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves, Nat. Struct. Mol. Biol., 17, 117, 10.1038/nsmb.1742 · DOI
- Salmaso, 2014, Neurobiology of premature brain injury, Nat. Neurosci., 17, 341, 10.1038/nn.3604 · DOI
- Schneider, 2011, Homozygous THAP1 mutations as cause of early-onset generalized dystonia, Mov. Disord., 26, 858, 10.1002/mds.23561 · DOI
- Sengel, 2011, Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain, J. Neurochem., 118, 1087, 10.1111/j.1471-4159.2011.07386.x · DOI
- Shaw, 2010, Childhood psychiatric disorders as anomalies in neurodevelopmental trajectories, Hum. Brain Mapp., 31, 917, 10.1002/hbm.21028 · DOI · Paper page
- Soriano, 1999, Generalized lacZ expression with the ROSA26 Cre reporter strain, Nat. Genet., 21, 70, 10.1038/5007 · DOI
- Standaert, 2011, Update on the pathology of dystonia, Neurobiol. Dis., 42, 148, 10.1016/j.nbd.2011.01.012 · DOI
- Tanabe, 2009, Primary dystonia: molecules and mechanisms, Nat. Rev. Neurol., 5, 598, 10.1038/nrneurol.2009.160 · DOI
- Tanabe, 2016, Neuronal nuclear membrane budding occurs during a developmental window modulated by torsin paralogs, Cell Rep., 16, 3322, 10.1016/j.celrep.2016.08.044 · DOI
- van der Meer, 2012, White matter abnormalities in gene-positive myoclonus-dystonia, Mov Disord., 27, 1666, 10.1002/mds.25128 · DOI
- Weisheit, 2015, A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation, Hum. Mol. Genet., 24, 6459, 10.1093/hmg/ddv355 · DOI
- Winters, 2011, Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4, J. Neurosci., 31, 17736, 10.1523/JNEUROSCI.1482-11.2011 · DOI
- Xiromerisiou, 2012, THAP1 mutations and dystonia phenotypes: genotype phenotype correlations, Mov. Disord., 27, 1290, 10.1002/mds.25146 · DOI
- Yellajoshyula, 2011, Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state, Proc. Natl. Acad. Sci. USA, 108, 3294, 10.1073/pnas.1012053108 · DOI
Cited by
Sorted by citations
Zhang, Y., Cheng, Z., Huang, S., Sharma, T., Barbosa, D., Yu, G., & Sun, L. O. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116252 · Cited by 4
Metadata
- Authors
- Yellajoshyula, D., Liang, C.-C., Pappas, S. S., Penati, S., Yang, A., Mecano, R., Kumaran, R., Jou, S., Cookson, M. R., & Dauer, W. T.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 42
- Issue
- 1
- Pages
- 52-67.e4
- ISSN
- 1534-5807
- PMC
- PMC5847273
- Cited by
- 62
- References
- 7
- Language
- en
- Licence
- Funders
- NINDS (RO1NS077730)
- Dystonia Medical Research Foundation
- NIH (2UL1TR000433)
- National Institute on Aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review