Reconsidering the Passive Diffusion Model of Steroid Hormone Cellular Entry
Open accessAbstract
Steroid hormones have long been thought to enter target cells via passive diffusion through the plasma membrane. Now, reporting in Developmental Cell, Okamoto et al. (2018) demonstrate that, at least for Drosophila, steroid hormones require a protein transporter for cellular entry.
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20E is not passively entering the cell membrane.
“These data suggest that 20E is not passively enter the cell membrane [68].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [68]
Cites
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A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila
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Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60 · see citing works
- Authors
- Neuman, S. D., & Bashirullah, A.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Bashirullah, Arash
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 47
- Issue
- 3
- Pages
- 261-262
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2900384603
- Cited by
- 6
- References
- 10
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 2 · 2018: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM123204)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- steroid hormones, passive diffusion, plasma membrane, protein transporters, Drosophila, membrane transport
- MeSH terms
- Animals, Biological Transport, Drosophila, Hormones, Steroids, Membrane Transport Proteins
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