Association between current perceived stress and incident diabetes is dependent on occupational status: Evidence from the IPC cohort study
Abstract
Aim The role of stress in the onset of type 2 diabetes is a widespread lay belief, yet observational studies have produced inconsistent results. This study aimed to test the hypothesis that the association between perceived stress and incident diabetes might depend on occupational status (OS). Methods The four-item Perceived Stress Scale (PSS-4) was completed at baseline by 22,567 participants in the labour force (16,193 men, 6374 women; mean age: 44.5±9.8 years) who had undergone two health checkups subsidized by the French national healthcare system. All subjects were free from diabetes at baseline, defined as a fasting blood glycaemia≥7mmol/L or the use of antidiabetic drugs. Results After a mean follow-up of 5.3±2.1 years, 527 participants (2.3%) had incident diabetes. After adjusting for sociodemographic, behavioural and biomedical risk factors as well as self-rated health, the association between baseline perceived stress and diabetes at follow-up was non-significant for the total study population. However, perceived stress was significantly associated with incident diabetes in participants of low OS [odds ratio (OR) for a five-point increment: 1.39; 95% confidence interval (CI): 1.02-1.90]. In contrast, there was a negative association between perceived stress and diabetes among those of high OS (OR: 0.60; 95% CI: 0.41-0.88) and no association within other occupational categories. The interaction between perceived stress and OS was significant (P<0.01). Conclusion This study suggests that the association between perceived stress and diabetes onset is dependent on OS. Furthermore, this association does not appear to be explained by the classical risk factors for diabetes.
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A link exists between perceived stress and development of T2DM.
“Considering the evidence as a whole, a link seems to exist between perceived stress and development of T2DM.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [85]
The association between perceived stress and T2DM varies by sex or socioeconomic status in some studies.
“However, this association has been shown in some studies to vary by sex or socioeconomic status (as measured by occupational status), which indicates that these factors might moderate this relationship.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [85]
In French adults (n=22,567, n=527 incident cases of diabetes mellitus; 5.3-year follow-up), perceived stress using the four-item Perceived Stress Scale was associated only in those of low occupational status (OR 1.39, 95% CI 1.02-...).
“French adults ( n = 22,567, n=527 incident cases of diabetes mellitus; 5.3 year follow-up) | Perceived stress using the four-item perceived stress Scale | ‡ Association only in those of low occupational status OR 1.39 (95% CI 1.02-”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Wiernik (2016) 78
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Type 2 diabetes mellitus and psychological stress — a modifiable risk factor
Hackett, R. A., & Steptoe, A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.64 · Cited by 480 · see citing works
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- Authors
- Wiernik, E., Nabi, H., Thomas, F., Pannier, B., Hanon, O., Simon, T., Simon, J.-M., Danchin, N., Limosin, F., Czernichow, S., & Lemogne, C.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Frèderic-Henri Manhès (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Corresponding author
- Wiernik, E.
- ORCID
- Venue
- Diabetes & Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 42
- Issue
- 5
- Pages
- 328-335
- ISSN
- 1262-3636 (ISSN-L)
- OpenAlex
- W2291670446
- Cited by
- 20
- References
- 9
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- perceived stress, type 2 diabetes, new-onset diabetes, occupational status, socioeconomic status, Perceived Stress Scale, labor force, diabetes risk factors
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Employment, Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Stress, Psychological
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