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Cited by 109Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesObesity, Physical Activity, Diet

Low risk threshold for acquired diabetogenic factors in Asian Indians

Ramachandran, A., Snehalatha, C., Vijay, V.·2004·Diabetes Research and Clinical Practice
DOI 10.1016/j.diabres.2004.03.012
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Abstract

India is facing an epidemic of type 2 diabetes, with high prevalence in urban areas. Urbanisation and associated life style changes adversely affect the risk factors for diabetes unmasking the high genetic tendency existing in the population. Various epidemiological studies in Indians have shown that the increasing prevalence of diabetes could be attributed to a high genetic risk and lower risk thresholds for acquired risk factors such as age, obesity, abdominal adiposity and a high percentage of body fat. Diabetes occurs at a younger age in Indians compared to Whites. The risk of diabetes increases with a body mass index (BMI) of >23 kg/m(2) and waist circumference of 85 cm for men and 80 cm for women in Asian Indians. For a given BMI, Asian Indians have higher central adiposity. There is also evidence of higher insulin resistance amongst Indians, and this is partly explained by higher body fat percentage. A large proportion of urban adults has the metabolic syndrome also which predisposes them to both diabetes and cardiovascular diseases. Recognition of these conditions and institution of early preventive measures are urgently needed.

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  • Impaired glucose tolerance is highly prevalent in native Asian Indians, who have unique features such as young age of diabetes onset, lower BMI, high insulin resistance, and lower thresholds for diabetic risk factors.

    “IGT is highly prevalent in native Asian Indians. This population has several unique features such as a young age of diabetes onset and lower BMI along with high rates of insulin resistance and lower thresholds for diabetic risk factors [12].”

    From Metformin: An Old But Still the Best Treatment for Type 2 Diabetes (2013) · cites this paper as [12]

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Authors
Ramachandran, A., Snehalatha, C., & Vijay, V.
Affiliations
M.V. Hospital for Diabetes and Diabetes Research Centre (IN)
Corresponding author
Ramachandran, A.
ORCID
Ramachandran, A.
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
2004-09
Volume
65
Issue
3
Pages
189-195
ISSN
0168-8227 (ISSN-L)
DOI
10.1016/j.diabres.2004.03.012
OpenAlex
W2060473900
Cited by
109
References
36
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 9 · 2013: 4 · 2012: 2
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
type 2 diabetes, Asian Indians, acquired risk factors, body mass index, waist circumference, abdominal obesity, obesity, insulin resistance, metabolic syndrome, urbanization, diabetes prevention
MeSH terms
Adult, Age Factors, Diabetes Mellitus, Type 2, Female, Humans, India, Insulin Resistance, Life Style, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Prevalence, Glucose Intolerance, Genetic Predisposition to Disease, Metabolic Syndrome, White People

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