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Cited by 1,618Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesIndigenous Health and Education

Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians

McKeigue, P.M., Shah, B., Marmot, M.G.·1991·The Lancet
DOI 10.1016/0140-6736(91)91164-p
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Abstract

The hypothesis that the high mortality from coronary heart disease (CHD) in South Asians settled overseas compared with other populations is due to metabolic disturbances related to insulin resistance was tested in a population survey of 3193 men and 561 women aged 40-69 years in London, UK. The sample was assembled from industrial workforces and general practitioners' lists. In comparison with the European group, the South Asian group had a higher prevalence of diabetes (19% vs 4%), higher blood pressures, higher fasting and post-glucose serum insulin concentrations, higher plasma triglyceride, and lower HDL cholesterol concentrations. Mean waist-hip girth ratios and trunk skinfolds were higher in the South Asian than in the European group. Within each ethnic group waist-hip ratio was correlated with glucose intolerance, insulin, blood pressure, and triglyceride. These results confirm the existence of an insulin resistance syndrome, prevalent in South Asian populations and associated with a pronounced tendency to central obesity in this group. Control of obesity and greater physical activity offer the best chances for prevention of diabetes and CHD in South Asian people.

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Crossref · 10.1016/0140-6736(91)91164-p

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33 of 33 references verified0 citation errors · 0 not checkable

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  • Eastern-Asians and Asian-Indians tend to develop type 2 diabetes mellitus without the same degree of generalized adiposity and with a greater tendency to develop central obesity.

    “In contrast to other ethnic groups, Eastern-Asians and Asian-Indians tend to develop T2DM without the same degree of generalized adiposity (2) and with a greater tendency to develop central obesity (3).”

    From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [3]

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Authors
McKeigue, P. M., Shah, B., & Marmot, M. G.
Affiliations
  • University College London (GB)
  • Indian Council of Medical Research (IN)
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1991-02
Volume
337
Issue
8738
Pages
382-386
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(91)91164-p
OpenAlex
W2146158338
Cited by
1,618
References
33
Citations by year
2026: 9 · 2025: 14 · 2024: 18 · 2023: 28 · 2022: 29 · 2021: 30 · 2020: 47 · 2019: 25 · 2018: 40 · 2017: 31 · 2016: 60 · 2015: 64 · 2014: 69 · 2013: 63 · 2012: 66
FWCI
29.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Health Professions › General Health Professions › Indigenous Health and Education
Keywords
abdominal obesity, insulin resistance, South Asians, diabetes prevalence, coronary artery disease, cardiovascular risk, waist-to-hip ratio, waist circumference, skinfold thickness, blood pressure, serum insulin, triglycerides, HDL cholesterol, impaired glucose tolerance, ethnic differences, diabetes prevention, physical activity
MeSH terms
Adult, Aged, Anthropometry, Asia, Southeastern, Blood Glucose, Blood Pressure, Cholesterol, Coronary Disease, Diabetes Mellitus, Type 2, Evaluation Studies as Topic, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, London, Male, Middle Aged, Obesity, Sex Factors, Syndrome, Triglycerides

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