Anti-thyroid peroxidase antibody, IA-2 antibody, and fasting C-peptide levels predict beta cell failure in patients with latent autoimmune diabetes in adults (LADA)—A 5-year follow-up of the Ehime study
Abstract
Objective To clarify the natural course and factors involved in beta cell failure in Japanese latent autoimmune diabetes in adults (LADA) patients. Research design and methods Insulin secretion in 57 LADA patients identified from among 4980 adult-onset diabetic patients in a hospital-based Ehime study were examined over a 5-year period. Postprandial serum C-peptide levels below 0.33 nmol/l were defined as beta cell failure. The involvement of clinical and immunological factors in the progression to beta cell failure were evaluated. Results Forty-two of the fifty-seven LADA patients completed the 5-year follow-up. Eleven (26.2%) required insulin treatment and five (11.9%) progressed to beta cell failure. A Cox regression analysis revealed that positive anti-thyroid peroxidase antibody (TPOAb) and insulinoma-associated protein 2 (IA-2Ab) were associated with the need for insulin treatment (p Conclusions Japanese LADA patients are a heterogeneous population. In addition to IA-2 antibody, presence of TPOAb and fasting C-peptide level could indicate an oncoming deterioration of beta cell function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared with people who have T2DM, those with LADA tend to have fewer components of the metabolic syndrome.
“Compared with people who have T2DM, those with LADA tend to be younger at diagnosis, leaner, have faster decline in β-cell function and fewer components of the metabolic syndrome80,81.”
From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [81]
Compared with people who have T2DM, those with LADA tend to be leaner.
“Compared with people who have T2DM, those with LADA tend to be younger at diagnosis, leaner, have faster decline in β-cell function and fewer components of the metabolic syndrome80,81.”
From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [81]
Compared with people who have T2DM, those with LADA tend to be younger at diagnosis.
“Compared with people who have T2DM, those with LADA tend to be younger at diagnosis, leaner, have faster decline in β-cell function and fewer components of the metabolic syndrome80,81.”
From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [81]
Compared with people who have T2DM, those with LADA tend to have faster decline in β-cell function.
“Compared with people who have T2DM, those with LADA tend to be younger at diagnosis, leaner, have faster decline in β-cell function and fewer components of the metabolic syndrome80,81.”
From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [81]
Cites
Type 1 diabetes associated autoimmunity: natural history, genetic associations and screening
Barker, J. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1679 · Cited by 350 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The epidemiology of type 1 diabetes mellitus in older adults
Tomic, D., Harding, J. L., Jenkins, A. J., Shaw, J. E., & Magliano, D. J. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01046-z · Cited by 58 · see citing works
“Compared with people who have T2DM, those with LADA tend to be younger at diagnosis, leaner, have faster decline in β-cell function and fewer components of the metabolic syndrome 80,81 .”
Past, present and future of latent autoimmune diabetes in adults
Liu, B., Xiang, Y., Liu, Z., & Zhou, Z. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3205 · Cited by 50 · see citing works
Oikawa, Y., Tanaka, H., Uchida, J., Atsumi, Y., Osawa, M., Katsuki, T., Kawai, T., & Shimada, A. (2017) · Endocrine Journal · doi:10.1507/endocrj.ej16-0328 · Cited by 17 · see citing works
- Authors
- Murao, S., Kondo, S., Ohashi, J., Fujii, Y., Shimizu, I., Fujiyama, M., Ohno, K., Takada, Y., Nakai, K., Yamane, Y., Osawa, H., & Makino, H.
- Affiliations
- Matsuyama Shimin Hospital (JP)
- Matsuyama Red Cross Hospital (JP)
- The University of Tokyo (JP)
- Ehime Prefectural Central Hospital (JP)
- Jyuzen General Hospital (JP)
- Ehime University (JP)
- Corresponding author
- Makino, Hideichi
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 80
- Issue
- 1
- Pages
- 114-121
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2131647275
- Cited by
- 57
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- latent autoimmune diabetes in adults, beta-cell failure, thyroid peroxidase antibodies, IA-2 autoantibodies, thyroglobulin antibodies, fasting C-peptide, HLA class II, disease progression, Japanese patients
- MeSH terms
- Insulin Secretion, Adult, Aged, Autoantibodies, C-Peptide, Diabetes Mellitus, Type 1, Female, Follow-Up Studies, Haplotypes, HLA-DQ Antigens, HLA-DR Antigens, Humans, Insulin, Iodide Peroxidase, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Biomarkers, Genetic Predisposition to Disease, Asian People, Insulin-Secreting Cells, HLA-DRB1 Chains, HLA-DQ beta-Chains
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
