Cited by 350Diabetes and associated disordersCeliac Disease Research and ManagementAdrenal Hormones and Disorders

Type 1 diabetes associated autoimmunity: natural history, genetic associations and screening

Barker, Jennifer M.·2006·The Journal of Clinical Endocrinology & Metabolism

Abstract

CONTEXT: Type 1 diabetes (T1D) is associated with autoimmune thyroid disease (AIT), celiac disease (CD), Addison's disease (AD), and other autoimmune diseases. These diseases can occur together in defined syndromes with distinct pathophysiology and characteristics: autoimmune polyendocrine syndrome I, autoimmune polyendocrine syndrome II, and the immunodysregulation polyendocrinopathy enteropathy X-linked syndrome. EVIDENCE ACQUISITION: Review of the medical literature was performed with particular attention to the natural history, genetic factors, and syndromes associated with T1D, AIT, CD, and AD. EVIDENCE SYNTHESIS: Genetic risk for these diseases overlaps and includes genes within the major histocompatibility complex (MHC) such as the human leukocyte antigens (HLA) DR and DQ alleles and the MHC I-related gene A (MIC-A). Other genes outside of the MHC have been associated with these autoimmune diseases, including the gene encoding the lymphoid tyrosine phosphatase (PTPN22) and the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene. CONCLUSION: Genetic risk for T1D overlaps with AIT, CD, and AD. Disease risk is associated with organ-specific autoantibodies, which can be used to screen subjects with T1D.

Integrity signals

Registry

Crossref · 10.1210/jc.2005-1679

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  • The association between type 1 diabetes and other autoimmune diseases, including autoimmune thyroid disease, Addison's disease, celiac disease, and autoimmune gastritis, is well established.

    “An association between T1D and other autoimmune diseases, such as autoimmune thyroid disease, Addison’s disease, celiac disease, and autoimmune gastritis, is well established52.”

    From Epidemiology of type 1 diabetes (2010) · cites this paper as [52]

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Authors
Barker, J. M.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Barker, Jennifer M.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2006-04
Volume
91
Issue
4
Pages
1210-1217
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2036511637
Cited by
350
References
120
Citations by year
2026: 7 · 2025: 6 · 2024: 16 · 2023: 9 · 2022: 13 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 25 · 2017: 8 · 2016: 12 · 2015: 24 · 2014: 20 · 2013: 28 · 2012: 25
FWCI
14.05
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (U19AI046374, AI 46374)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057516, DK 57516, DK 32493, DK32083)
  • National Center for Research Resources (RR-00051, RR 00069, M01RR000069)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
type 1 diabetes, autoimmune thyroid disease, celiac disease, Addison's disease, autoimmune polyendocrine syndrome type 1, autoimmune polyendocrine syndrome type 2, genetic risk factors, major histocompatibility complex, HLA-DR, HLA-DQ, PTPN22, CTLA-4, autoantibodies, screening, natural history (disease)
MeSH terms
Adrenal Gland Diseases, Animals, Autoimmune Diseases, Celiac Disease, Diabetes Mellitus, Type 1, Genetic Testing, Humans, Risk Factors, Thyroiditis, Autoimmune

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