Endothelial dysfunction: causes and consequences in patients with diabetes mellitus.
Abstract
Vascular endothelium plays a major role in maintaining cardiovascular homeostasis. Nitric oxide is the most powerful vasodilating compound. Diabetes disrupts endothelial integrity through an increased oxidative stress. Recent evidence indicates that there is a strong interaction between diabetes, the secretory proteins of adipocytes, called adipokines, and endothelium. Endothelial dysfunction may precede the development of overt DM, and a prolonged and repeated exposure to postprandial hyperglycemia may play an important role in the development of atherosclerosis, even in those who have normal fasting plasma glucose levels.
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Lower nitric oxide availability has been linked to impaired endothelial function and higher risk of hypertension and cardiovascular disease.
“Reduced NO bioavailability has been associated with impairment of endothelial function and increased risk of hypertension and cardiovascular diseases (17)(18)(19)(20).”
From Inorganic Nitrate and Beetroot Juice Supplementation Reduces Blood Pressure in Adults: A Systematic Review and Meta-Analysis (2013) · cites this paper as [18]
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- Authors
- Avogaro, A., Kreutzenberg, S. V. D., & Fadini, G.
- Affiliations
- University of Padua (IT)
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 82
- Pages
- S94-S101
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W1992504098
- Cited by
- 81
- References
- 54
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- endothelial dysfunction, diabetes mellitus, nitric oxide, oxidative stress, adipokines, adipocytes, postprandial hyperglycemia, atherosclerosis, cardiovascular homeostasis
- MeSH terms
- Diabetes Mellitus, Endothelium, Vascular, Humans, Nitric Oxide, Oxidative Stress, Adipokines
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