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Cited by 153Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsDiabetes, Cardiovascular Risks, and Lipoproteins

Postprandial Myocardial Perfusion in Healthy Subjects and in Type 2 Diabetic Patients

Scognamiglio, Roldano, Negut, Christian, De Kreutzenberg, Saula Vigili, Tiengo, Antonio, Avogaro, Angelo·2005·Circulation
DOI 10.1161/circulationaha.104.495127
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Abstract

Background— In diabetic patients, postprandial hyperglycemia is a more powerful risk factor for cardiovascular disease than fasting hyperglycemia itself. A negative influence of acute hyperglycemia on systemic endothelial function (brachial artery) has been shown. However, myocardial perfusion during postprandial hyperglycemia has not been investigated. Methods and Results— We evaluated the effects of a standardized mixed meal on myocardial perfusion in 20 healthy subjects and 20 consecutive patients with type 2 diabetes mellitus without macrovascular or microvascular complications. Myocardial perfusion was assessed in fasting and postprandial states by myocardial contrast echocardiography. Fasting myocardial flow velocity (β, 0.65±0.27 versus 0.67±0.24; P =NS), myocardial blood volume (MBV; 8.3±1.2 versus 8.4±2; P =NS), and myocardial blood flow (5.4±1.5 versus 5.6±2; P =NS) did not differ between control subjects and diabetic patients. In the postprandial state, β (0.67±0.24 versus 0.92±0.35; P <0.01), MBV (8.4±2 versus 10.9±2.7; P <0.01), and myocardial blood flow (5.6±2 versus 9.9±2.8; P <0.01) increased significantly in control subjects. In diabetic patients, β increased (0.65±0.27 versus 0.8±0.24; P <0.01) but MBV (8.3±1.2 versus 4.3±1.3; P <0.01) and myocardial blood flow (5.4±1.5 versus 3.4±0.9; P <0.01) decreased significantly. Changes in MBV (expressed as [(MBV postprandial −MBV fasting )/MBV fasting ]×100) were significantly correlated with postprandial glycemia levels in diabetic patients. Conclusions— Postprandial hyperglycemia determines myocardial perfusion defects in type 2 diabetic patients. They are secondary to deterioration in microvascular function causing a decrease in MBV. In diabetic patients without microvascular or macrovascular complications, postprandial myocardial perfusion defects may represent an early marker of the atherogenic process in the coronary circulation; hence, its reversal constitutes a potential goal of treatment.

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    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [111]

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    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [111]

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    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [111]

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Authors
Scognamiglio, R., Negut, C., De Kreutzenberg, S. V., Tiengo, A., & Avogaro, A.
Affiliations
  • University of Padua (IT)
  • From Metabolic Cardiology, Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova Medical School, Padua, Italy.
ORCID
Avogaro, Angelo
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-07-12
Volume
112
Issue
2
Pages
179-184
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.104.495127
OpenAlex
W2033063740
Cited by
153
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 5
FWCI
11.40
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
postprandial hyperglycemia, type 2 diabetes, myocardial perfusion, myocardial blood flow, myocardial blood volume, myocardial contrast echocardiography, mixed meal, microvascular dysfunction, diabetic cardiomyopathy, cardiovascular risk in diabetes, endothelial dysfunction, postprandial blood glucose, myocardial ischemia risk, myocardial stunning
MeSH terms
Adult, Blood Flow Velocity, Blood Volume, Coronary Circulation, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Eating, Fasting, Female, Humans, Hyperglycemia, Male, Microcirculation, Middle Aged, Prospective Studies, Case-Control Studies, Postprandial Period

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