Predictors of diastolic dysfunction among minority patients with newly diagnosed type 2 diabetes

Kazlauskaite, Rasa; Doukky, Rami; Evans, Arthur; Margeta, Bosko; Ruchi, Arora; Fogelfeld, Leon; Kelly, Russell F.

doi:10.1016/j.diabres.2009.12.007

Cited by 15Cardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

Predictors of diastolic dysfunction among minority patients with newly diagnosed type 2 diabetes

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Kazlauskaite, Rasa, Doukky, Rami, Evans, Arthur, Margeta, Bosko, Ruchi, Arora, Fogelfeld, Leon, Kelly, Russell F.·2010·Diabetes Research and Clinical Practice

DOI 10.1016/j.diabres.2009.12.007PMC PMC3390420

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Aim To determine mutable risk factors for asymptomatic diastolic dysfunction in ethnic minority patients newly diagnosed with type 2 diabetes.Methods We recruited consecutive adults with newly diagnosed diabetes who had no signs or symptoms or history of heart disease. All patients received standardized evaluation including interview, physical examination, laboratory tests and echocardiogram with tissue Doppler studies. We used logistic regression models to identify mutable risk factors for diastolic dysfunction.Results Among 126 study subjects (52% women, age 45+/-10 years, BMI 33+/-7, 42% with hypertension, 100% ejection fraction > or =50%), evidence of diastolic dysfunction was present in 64 (51%). After controlling for age, heart rate and blood pressure, independent predictors of diastolic dysfunction included physical inactivity (OR: 2.3; 95% CI: 0.9-6.1; P=0.08) and glucose (OR: 4.9; 95% CI: 1.4-17.8; P=0.02). Physical inactivity was associated with early diastolic dysfunction (impaired relaxation), whereas epicardial fat thickness and glucose levels were associated with late diastolic dysfunction (impaired compliance). The hs-CRP and BNP levels were not associated with diastolic dysfunction.Conclusions Asymptomatic diastolic dysfunction was prevalent among urban minority patients newly diagnosed with diabetes. Important differences exist among factors that affect early and late diastolic function that may have prognostic and therapeutic implications.

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EAT adiposity is associated with alterations of myocardial function in T2DM people and may be a predictor of diastolic dysfunction in newly diagnosed patients.
“Importantly, EAT adiposity is associated with alterations of myocardial function in T2DM people and may be a predictor of diastolic dysfunction in new diagnosed patients [60,61].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [61]

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Authors: Kazlauskaite, R., Doukky, R., Evans, A., Margeta, B., Ruchi, A., Fogelfeld, L., & Kelly, R. F.
Affiliations: Rush University Medical Center (US)
University of Illinois Chicago (US)
ORCID: Kazlauskaite, Rasa
Doukky, Rami
Fogelfeld, Leon
Venue: Diabetes Research and Clinical Practice
Publisher: Elsevier BV
Published: 2010-05
Volume: 88
Issue: 2
Pages: 189-195
ISSN: 0168-8227 (ISSN-L)
DOI: 10.1016/j.diabres.2009.12.007
PMC: PMC3390420
OpenAlex: W2089312297
Cited by: 15
References: 26
Citations by year: 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 1 · 2014: 2
FWCI: 0.88
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes Research and Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (P50HL105189)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: diastolic dysfunction, type 2 diabetes, newly diagnosed diabetes, ethnic minority patients, physical inactivity, blood glucose, epicardial fat thickness, early diastolic dysfunction, tissue Doppler imaging, cardiovascular risk factors
MeSH terms: Adult, Diabetes Mellitus, Type 2, Diastole, Female, Humans, Hypertension, Male, Middle Aged, Motor Activity, Cardiomyopathies, Pericardium, Regression Analysis, Risk Factors, Stroke Volume, Intra-Abdominal Fat

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Predictors of diastolic dysfunction among minority patients with newly diagnosed type 2 diabetes

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