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Cited by 45Diabetes Management and EducationDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: the Microalbuminuria Education and Medication Optimisation (MEMO) Study

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Crasto, W., Jarvis, J., Khunti, K., Skinner, T.C., Gray, L.J., Brela, J., Troughton, J., Daly, H. +4 more·2011·Diabetes Research and Clinical Practice
DOI 10.1016/j.diabres.2011.05.008
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Abstract

Aims To determine whether tighter cardiovascular risk factor control with structured education in individuals with type 2 diabetes (T2DM) and microalbuminuria benefits cardiovascular risk factors. Methods Participants from a multiethnic population, recruited from primary care and specialist clinics were randomised to intensive intervention with structured patient (DESMOND model) education (n=94) or usual care by own health professional (n=95). Primary outcome change in HbA1c at 18months. Secondary outcomes changes in blood pressure (BP), cholesterol, albuminuria, proportion reaching risk factor targets, modelled cardiovascular risk scores. Results Mean (SD) age and diabetes duration of participants were 61.5 (10.5) and 11.5 (9.3) years, respectively. At 18months, intensive intervention showed significant improvements in HbA1c (7.1(1.0) vs. 7.8(1.4)%, p Conclusions Intensive intervention showed greater improvements in metabolic control and cardiovascular risk profile with lower rates of moderate and severe hypoglycaemia. Intensive glycaemic interventions should be underpinned by structured education promoting self-management in T2DM.

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Crossref · 10.1016/j.diabres.2011.05.008

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  • An HbA1c target of ≤6.5% probably decreased the incidence of moderately increased albuminuria and kidney failure.

    “Six studies compared a target HbA1c of # 6.5% to higher HbA1c targets (standard glycemic control) and found that an HbA1c target of # 6.5% probably decreased the incidence of moderately increased albuminuria, and kidney failure (Supplementary Table S12 239,240,242 -244,252 )”

    From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [252]

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Authors
Crasto, W., Jarvis, J., Khunti, K., Skinner, T. C., Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E., & Davies, M. J.
Affiliations
  • University of Leicester (GB)
  • University Hospitals of Leicester NHS Trust (GB)
  • Flinders University (AU)
Corresponding author
Crasto, W.
ORCID
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
2011-09
Volume
93
Issue
3
Pages
328-336
ISSN
0168-8227 (ISSN-L)
DOI
10.1016/j.diabres.2011.05.008
OpenAlex
W2049323164
Cited by
45
References
30
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 2 · 2012: 2
FWCI
2.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Figshare (submittedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, microalbuminuria, patient education, self-management, tight glycemic control, HbA1c, blood pressure, cholesterol, cardiovascular risk factors, cardiovascular risk score, hypoglycemia, multifactorial intervention
MeSH terms
Adult, Aged, Aged, 80 and over, Albuminuria, Antihypertensive Agents, Hypolipidemic Agents, Aspirin, Blood Pressure, Cholesterol, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Risk Factors

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