The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Effect of laparoscopic Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus with hypertension: A randomized controlled trial
Abstract
Aims The aim of this study was to evaluate the effect of laparoscopic Roux-en-Y gastric bypass (RYGB) surgery compared with usual care with and without Exenatide therapy in obese people with type 2 diabetes mellitus (T2DM) and hypertension.Methods 108 obese T2DM with hypertension were enrolled and randomly allocated to usual care (group A), usual care plus Exenatide (group B), and RYGB surgery (group C). Demographic characteristics, metabolic parameters and cardiac structure/function along with inflammatory cytokines were measured and compared before and after 12 months.Results At 12 months, diabetes remission had occurred in no patients in groups A and B versus 90% in group C, and there was a significant decrease in requirement of antihypertensive drugs in group C compared with groups A and B (P<0.05). Other parameters (body mass index, hemoglobin A1c, homeostasis model assessment of insulin resistance, lipids), inflammation index (high sensitivity C-reactive protein, tumor necrosis factor-α, high molecular weight adiponectin) and cardiac structure (left ventricular mass index) were significantly improved in groups B and C, but patients in group C had the greatest degree of improvement (P<0.05).Conclusion RYGB surgery improves a number of parameters including cardiovascular function in obese hypertensive people with T2DM. This is likely to be due to, at least in part, an improvement in the abnormal metabolic panel and to reduced inflammation.
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“Fifteen RCTs were identified comparing weight loss after bariatric surgery or medical therapy (5 reporting on RYGB, 3 on LAGB and the rest on mixed patient populations undergoing sleeve gastrectomy, BPD/DS, sleeve gastrectomy and/or banding) [21–35].”
In the citing paper
“Partial or total remission rates in type 2 diabetes as high as 80% to 90% have been observed to occur following bariatric surgery [40-45].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [45]
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Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes
Mingrone, G., Panunzi, S., De Gaetano, A., Guidone, C., Iaconelli, A., Leccesi, L., Nanni, G., Pomp, A., Castagneto, M., Ghirlanda, G., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200111 · Cited by 1,791
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P.-Y. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,698
Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
Lee, H., Kim, J.-J., Kim, H. J., Shong, M., Ku, B. J., & Jo, E. (2012) · Diabetes · doi:10.2337/db12-0420 · Cited by 745
Evaluation of risk factors for development of complications in Type II diabetes in Europe
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Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., Goenka, N., Thomas, E. L., Adams, V. L., Pushpakom, S. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050117 · Cited by 226
The Inflammasome in Atherosclerosis and Type 2 Diabetes
Masters, S. L., Latz, E., & O’Neill, L. A. J. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001902 · Cited by 169
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Diabetes After Bariatric Surgery
Bello-Ramos, J. C., Rizo, I. M., & Alexanian, S. M. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-44648-1_22
Sebastian, S. A., Shah, Y., & Krishnamoorthy, G. (2025) · Next research. · doi:10.1016/j.nexres.2025.100318
Almazrouei, B., Mousa, M., Marzouka, N., Barajas-Gamboa, J. S., Abril, C. M., & AlSafar, H. S. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-02002-1
Twelve-Month BMI and Metabolic Changes After Roux-en-Y Gastric Bypass in Women with Severe Obesity
Sgarioni, A. C., Farina, G. S., Bressan, T. S., Dalfovo, M. P., Carli, G. M. D., GIOVANARDI, H. J., Giovanardi, G. S., Selistre, L. D. S., & Garcia, R. M. R. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15155764
Gan, S., Zhang, Q., Zhang, C. P., Li, Y., Yin, Y., Ma, H., & ZHANG, Z. (2026) · Biomolecules · doi:10.3390/biom16081093
Metadata
- Authors
- Liang, Z., Wu, Q., Chen, B., Yu, P., Zhao, H., & Ouyang, X.
- Affiliations
- Army Medical University (CN)
- Yale University (US)
- Corresponding author
- Liang, Ziwen
- Venue
- Diabetes Research and Clinical Practice
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 101
- Issue
- 1
- Pages
- 50-56
- ISSN
- 0168-8227 (ISSN-L)
- OpenAlex
- W2140334292
- Cited by
- 206
- References
- 22
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 4 · 2023: 19 · 2022: 15 · 2021: 14 · 2020: 26 · 2019: 14 · 2018: 19 · 2017: 15 · 2016: 34 · 2015: 18 · 2014: 11 · 2013: 1
- FWCI
- 20.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Research and Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- laparoscopic Roux-en-Y gastric bypass, type 2 diabetes, hypertension, obesity, exenatide, diabetes remission, insulin resistance, inflammation, cardiac structure, left ventricular mass, C-reactive protein, adiponectin, TNF-α
- MeSH terms
- Adult, C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypertension, Male, Middle Aged, Obesity, Laparoscopy, Prognosis, Tumor Necrosis Factor-alpha, Gastric Bypass, Weight Loss, Body Mass Index
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