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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

Wen, Haitao, Gris, Denis, Lei, Yu, Jha, Sushmita, Zhang, Lu, Huang, Max Tze-Han, Brickey, Willie June, Ting, Jenny P-Y·2011·Nature Immunology
DOI 10.1038/ni.2022PMC PMC4090391
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Crossref · 10.1038/ni.2022

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  • Aldara vehicle cream contains isostearic acid, which can trigger low-grade innate immune activation, including IL-1 release.

    “It has been reported that Aldara vehicle cream contains isostearic acid, which has been reported to trigger low-grade innate immune activation, including IL-1 release38,39.”

    From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [39]

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Research works printed but not linked: 35

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  11. Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821–832 (2010). · DOI · Paper page
  12. Bauernfeind, F.G. et al. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787–791 (2009). · DOI
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  15. Woods, A. et al. Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol. Cell. Biol. 20, 6704–6711 (2000). · DOI
  16. Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222–230 (2011). · DOI · Paper page
  17. Egan, D.F. et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456–461 (2011). · DOI · Paper page
  18. Klionsky, D.J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151–175 (2008). · DOI · Paper page
  19. Xu, Y. et al. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27, 135–144 (2007). · DOI · Paper page
  20. Roden, M. Mechanisms of disease: hepatic steatosis in type 2 diabetes–pathogenesis and clinical relevance. Nat. Clin. Pract. Endocrinol. Metab. 2, 335–348 (2006). · DOI
  21. Furuhashi, M. & Hotamisligil, G.S. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 7, 489–503 (2008). · DOI
  22. Zenewicz, L.A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647–659 (2007). · DOI
  23. Hotamisligil, G.S. et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271, 665–668 (1996). · DOI · Paper page
  24. Uysal, K.T., Wiesbrock, S.M., Marino, M.W. & Hotamisligil, G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389, 610–614 (1997). · DOI · Paper page
  25. Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179–188 (2011). · DOI · Paper page
  26. Sabio, G. et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322, 1539–1543 (2008). · DOI · Paper page
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  33. Solle, M. et al. Altered cytokine production in mice lacking P2X7 receptors. J. Biol. Chem. 276, 125–132 (2001). · DOI
  34. Shornick, L.P. et al. Mice deficient in IL-1β manifest impaired contact hypersensitivity to trinitrochlorobenzone. J. Exp. Med. 183, 1427–1436 (1996). · DOI
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Metadata

Authors
Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P.-Y.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2011-04-10
Volume
12
Issue
5
Pages
408-415
ISSN
  • 1529-2908
  • 1529-2916
DOI
10.1038/ni.2022
PMC
PMC4090391
Cited by
1,698
References
15
Language
en
Licence
www.springer.com/tdm (tdm)

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