Cardiovascular risk assessment by coronary artery calcium score in subjects with maturity-onset diabetes of the young caused by glucokinase mutations

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

Richards, S., Aziz, N., Bale, S., Bick, D., Das, S., Gastier-Foster, J., Grody, W. W., Hegde, M., Lyon, E., Spector, E., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2015.30 · Cited by 32,594 · see citing works

A New Equation to Estimate Glomerular Filtration Rate

Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603 · see citing works

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023 · see citing works

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works

Quantification of coronary artery calcium using ultrafast computed tomography

Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., & Detrano, R. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90282-t · Cited by 7,786 · see citing works

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works

2. Classification and Diagnosis of Diabetes: <i>Standards of Medical Care in Diabetes—2022</i>

American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s002 · Cited by 4,792 · see citing works

Assessment of Coronary Artery Disease by Cardiac Computed Tomography

Budoff, M. J., Achenbach, S. S., Blumenthal, R. S., Carr, J. J., Goldin, J. G., Greenland, P., Guerci, A. D., Lima, J. A. C., Rader, D. J., Rubin, G. D., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178458 · Cited by 1,391 · see citing works

The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56)

STEVENS, R. J., KOTHARI, V., ADLER, A. I., & STRATTON, I. M. (2001) · Clinical Science · doi:10.1042/cs20000335 · Cited by 1,084 · see citing works

ACCF/AHA 2007 Clinical Expert Consensus Document on Coronary Artery Calcium Scoring By Computed Tomography in Global Cardiovascular Risk Assessment and in Evaluation of Patients With Chest Pain

Greenland, P., Bonow, R. O., Brundage, B. H., Budoff, M. J., Eisenberg, M. J., Grundy, S. M., Lauer, M. S., Post, W. S., Raggi, P., Redberg, R. F., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.001 · Cited by 959 · see citing works

Primary and subsequent coronary risk appraisal: New results from the Framingham study

D’Agostino, R. B., Russell, M. W., Huse, D. M., Ellison, R. C., Silbershatz, H., Wilson, P. W. F., & Hartz, S. C. (2000) · American Heart Journal · doi:10.1016/s0002-8703(00)90236-9 · Cited by 588 · see citing works

Update on mutations in glucokinase ( GCK ), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

Osbak, K. K., Colclough, K., Saint‐Martin, C., Beer, N. L., Bellanné‐Chantelot, C., Ellard, S., & Gloyn, A. L. (2009) · Human Mutation · doi:10.1002/humu.21110 · Cited by 481 · see citing works

Prevalence of Vascular Complications Among Patients With Glucokinase Mutations and Prolonged, Mild Hyperglycemia

Steele, A. M., Shields, B. M., Wensley, K. J., Colclough, K., Ellard, S., & Hattersley, A. T. (2014) · JAMA · doi:10.1001/jama.2013.283980 · Cited by 379 · see citing works

Coronary Artery Calcium Measurement

Becker, C. R., Kleffel, T., Crispin, A., Knez, A., Young, J., Schoepf, U. J., Haberl, R., & Reiser, M. F. (2001) · American Journal of Roentgenology · doi:10.2214/ajr.176.5.1761295 · Cited by 281 · see citing works

Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families

Velho, G., Blanché, H., Vaxillaire, M., Bellanné‐Chantelot, C., Pardini, V. C., Timsit, J., Passa, P., Deschamps, I., Robert, J., Weber, I. T., et al. (1997) · Diabetologia · doi:10.1007/s001250050666 · Cited by 264 · see citing works

Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes

Meininger, G. E., Scott, R. S., Alba, M., Shentu, Y., Luo, E., Amin, H., Davies, M. J., Kaufman, K. D., & Goldstein, B. J. (2011) · Diabetes Care · doi:10.2337/dc11-1200 · Cited by 212 · see citing works

Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis

Kramer, C. K., Zinman, B., Gross, J. L., Canani, L. H. S., Rodrigues, T. D. C., de Azevedo, M. J., & Retnakaran, R. R. (2013) · BMJ · doi:10.1136/bmj.f1654 · Cited by 189 · see citing works

Long-Term Prognosis After Coronary Artery Calcification Testing in Asymptomatic Patients

Shaw, L. J., Giambrone, A. E., Blaha, M. J., Knapper, J. T., Berman, D. S., Bellam, N., Quyyumi, A. A., Budoff, M. J., Callister, T. Q., & Min, J. K. (2015) · Annals of Internal Medicine · doi:10.7326/m14-0612 · Cited by 170 · see citing works

Coronary artery calcium: Alternate methods for accurate and reproducible quantitation

Yoon, H., Greaser, L. E., Mather, R. T., Sinha, S., McNitt‐Gray, M. F., & Goldin, J. G. (1997) · Academic Radiology · doi:10.1016/s1076-6332(97)80137-7 · Cited by 110 · see citing works

Mutations in GCK and HNF‐1α explain the majority of cases with clinical diagnosis of MODY in Spain

Estalella, I., Rica, I., de Nanclares, G. P., Bilbao, J. R., Vazquez, J. A., Pedro, J. I. S., Busturia, M. A., Castaño, L. A., & Spanish MODY Group (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02921.x · Cited by 108 · see citing works

Nitric oxide system and diabetic nephropathy

Dellaméa, B. S., Leitão, C. B., Friedman, R., & Canani, L. H. S. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-17 · Cited by 107 · see citing works

Update on clinical screening of maturity-onset diabetes of the young (MODY)

Peixoto-Barbosa, R., Reis, A. F., & Giuffrida, F. M. A. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00557-9 · Cited by 106 · see citing works

Excess body mass index loss predicts metabolic syndrome remission after gastric bypass

Nora, M. C., Guimarães, M., Almeida, R., Martins, P., Gonçalves, G., Santos, M., Morais, T., Freitas, C., & Monteiro, M. P. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-1 · Cited by 96 · see citing works

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.

Miller, S. P., Anand, G. R., Karschnia, E. J., Bell, G. I., LaPorte, D. C., & Lange, A. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1645 · Cited by 91 · see citing works

Phenotypic heterogeneity in monogenic diabetes: The clinical and diagnostic utility of a gene panel-based next-generation sequencing approach

Alkorta‐Aranburu, G., Carmody, D., Cheng, Y., Nelakuditi, V., Ma, L., Dickens, J. T., Das, S., Greeley, S. A. W., & del Gaudio, D. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.09.007 · Cited by 90 · see citing works

Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

Ceuninck, F. D., Kargar, C., Ilic, C., Caliez, A., Rolin, J., Umbdenstock, T., Vinson, C., Combettes, M., Fanti, B. A. D., Harley, E. A., et al. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02184.x · Cited by 74 · see citing works

Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus

Katagiri, H., Asano, T., Ishihara, H., Inukai, K., Anai, M., Yazaki, Y., Oka, Y., & Miyazaki, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)92494-z · Cited by 68 · see citing works

Identification of 21 novel glucokinase (GCK) mutations in UK and European Caucasians with maturity-onset diabetes of the young (MODY)

Thomson, K. L., Gloyn, A. L., Colclough, K., Batten, M., Allen, L. I. S., Beards, F., Hattersley, A. T., & Ellard, S. (2003) · Human Mutation · doi:10.1002/humu.9186 · Cited by 63 · see citing works

Inter-scan reproducibility of coronary calcium measurement using Multi Detector-Row Computed Tomography (MDCT)

Sabour, S., Rutten, A., van der Schouw, Y. T., Atsma, F., Grobbee, D. E., Mali, W. P. T. M., Bartelink, M.-L. E. L., Bots, M. L., & Prokop, M. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9123-4 · Cited by 59 · see citing works

Low prevalence of MODY2 and MODY3 mutations in Brazilian individuals with clinical MODY phenotype

Furuzawa, G. K., Giuffrida, F. M. A., Oliveira, C. S. V., Chacra, A. R., Dib, S. A., & Reis, A. F. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.06.011 · Cited by 34 · see citing works

Maturity-onset diabetes of the young (MODY) in Brazil: Establishment of a national registry and appraisal of available genetic and clinical data

Giuffrida, F. M. A., Moisés, R. S., Weinert, L. S., Calliari, L. E., Manna, T. D., Dotto, R. P., Franco, L. F., Caetano, L. A., Teles, M. G., Lima, R. A., et al. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.10.017 · Cited by 31 · see citing works

Familial adult onset hyperinsulinism due to an activating glucokinase mutation: implications for pharmacological glucokinase activation

Challis, B., Harris, J. R., Sleigh, A., Isaac, I., Orme, S. M., Seevaratnam, N., Dhatariya, K., Simpson, H., & Semple, R. K. (2014) · Clinical Endocrinology · doi:10.1111/cen.12517 · Cited by 29 · see citing works

Coronary Artery Calcium as a Synergistic Tool for the Age‐ and Sex‐Specific Risk of Cardiovascular and Cancer Mortality: The Coronary Artery Calcium Consortium

Dzaye, O. D. A., Rifai, M. A., Dardari, Z., Shaw, L. J., Al-Mallah, M. H., Marshall, C. H., Rozanski, A., Mortensen, M. B., Duebgen, M., Matsushita, K., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015306 · Cited by 22 · see citing works

Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

Průhová, Š., Dušátková, P., Kraml, P. J., Kulich, M., Prochazkova, Z., Brož, J., Zikmund, J., Cinek, O., Anděl, M., Pedersen, O. B., et al. (2013) · International Journal of Endocrinology · doi:10.1155/2013/718254 · Cited by 16 · see citing works

Diagnostic and prognostic value of absence of coronary artery calcification in patients with stable chest symptoms

Rijlaarsdam-Hermsen, D., Kuijpers, D., & van Dijkman, P. R. M. (2011) · Netherlands Heart Journal · doi:10.1007/s12471-011-0097-1 · Cited by 15 · see citing works

Intima-media thickness and endothelial dysfunction in GCK and HNF1A-MODY patients

Szopa, M., Osmenda, G., Wilk, G., Matejko, B., SKUPIEN, J. K., Zapała, B., Mlynarski, W. M., Guzik, T. J., & Malecki, M. T. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0713 · Cited by 14 · see citing works

A novel glucokinase deletion (p.Lys32del) and five previously described mutations co-segregate with the phenotype of mild familial hyperglycaemia (MODY2) in Brazilian families

Giuffrida, F. M. A., Calliari, L. E., Manna, T. D., Ferreira, J. G., Saddi-Rosa, P., Kunii, I. S., Furuzawa, G. K., Dias-da-Silva, M. R., & Reis, A. F. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.029 · Cited by 13 · see citing works

Three unreported glucokinase (GCK) missense mutations detected in the screening of thirty-two Brazilian kindreds for GCK and HNF1A-MODY

Weinert, L. S., Silveiro, S. P., Giuffrida, F. M. A., Cunha, V. T., Bulcão, C., Calliari, L. E., Manna, T. D., Kunii, I. S., Dotto, R. P., Dias-da-Silva, M. R., et al. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.08.006 · Cited by 12 · see citing works

Non-alcoholic fatty liver disease concerns with glucokinase activators

Hodson, L., & Brouwers, M. C. G. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30196-7 · Cited by 9 · see citing works

Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding – explains hyperglycemia in type 2 diabetic patients

Yellapu, N. K., Mahto, M. K., Valasani, K. R., Sarma, P. V. G. K., & Matcha, B. (2014) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2014.913989 · Cited by 7 · see citing works

Individuals with prediabetes identified by HbA1c undergoing coronary angiography have worse cardiometabolic profile than those identified by fasting glucose

Piveta, V. M., Bittencourt, C., Oliveira, C. S. V., Saddi-Rosa, P., Meira, D. M., Giuffrida, F. M. A., & Reis, A. F. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-138 · Cited by 7 · see citing works

Pitfalls in the diagnosis of frameshift mutations in the glucokinase (GCK) gene and the contribution of an additional cloning sequencing tool

Weinert, L. S., Giuffrida, F. M. A., Silveiro, S. P., Bulcão, C., Kunii, I. S., Dias-da-Silva, M. R., & Reis, A. F. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.01.033 · Cited by 2 · see citing works

Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE−/− mice

Hsiung, S., Knutsson, A., Vallejo, J., Dunér, P., Heinonen, S. E., Jönsson‐Rylander, A., Bengtsson, E., Nilsson, J. Å., & Hultgårdh‐Nilsson, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25942-3 · Cited by 1 · see citing works

NEUROD1 mutation in an Italian patient with maturity onset diabetes of the young 6: a case report

Brodosi, L., Baracco, B., Mantovani, V., & Pironi, L. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00864-w · Cited by 18 · see citing works

Insights from basic adjunctive examinations of GCK‐MODY , HNF1A‐MODY , and type 2 diabetes: A systemic review and meta‐analysis

Liu, J., Xiao, X., Zhang, Q., & Yu, M. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13390 · Cited by 6 · see citing works

Clinical screening for GCK-MODY in 2,989 patients from the Brazilian Monogenic Diabetes Study Group (BRASMOD) and the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG)

Peixoto-Barbosa, R., Calliari, L. E., Crispim, F., Moisés, R. S., Dib, S. A., Reis, A. F., & Giuffrida, F. M. A. (2024) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2023-0314 · Cited by 3 · see citing works

Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young

Arosemena, M., Chopra, K., Salguero, M. V., Reyes, D., Naylor, R. N., Wroblewski, K., Tasali, E., & Philipson, L. H. (2026) · Diabetes · doi:10.2337/db24-0787 · Cited by 2 · see citing works

Granuloma annulare and necrobiosis lipoidica in a patient with HNF1A-MODY

Brandes, G. I. G., Peixoto-Barbosa, R., Meski, A. P. G., Giuffrida, F. M. A., & Reis, A. F. (2022) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000477 · Cited by 2 · see citing works

Maturity-Onset Diabetes of the Young (MODY)

Giuffrida, F. M. A., & Moisés, R. S. (2026) · Contemporary Endocrinology · doi:10.1007/978-3-032-17036-1_8 · Cited by 1 · see citing works

Pancreatic beta‐cell function dynamics in youth with GCK , HNF1A , and KCNJ11 genes mutations during mixed meal tolerance test

Stankutė, I., Dobrovolskienė, R., Danytė, E., Steponavičiūtė, R., Schwitzgebel, V., & Verkauskienė, R. (2022) · Pediatric Diabetes · doi:10.1111/pedi.13404 · Cited by 1 · see citing works

Systematic Review of Monogenic Diabetes PrognosticsPreprint

Naylor, R. N., Amouyal, C., Philipson, L. H., Vatier, C., Dickens, L. T., PMDI, A., & Greeley, S. A. W. (2023) · medRxiv · doi:10.1101/2023.05.19.23290220 · Cited by 1 · see citing works

Genetic variants associated with fasting glucose levels in the Brazilian population: a review of studies of European-identified polymorphisms

Andaku, M. A., & Bonilla, C. (2024) · Revista de Nutrição · doi:10.1590/1678-9865202437e230094

Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

Průhová, Š., Dušátková, P., Kraml, P. J., Kulich, M., Prochazkova, Z., Brož, J., Zikmund, J., Cinek, O., Anděl, M., Pedersen, O. B., et al. (2013) · International Journal of Endocrinology · doi:10.1155/2013/718254 · Cited by 16 · see citing works

GCK-MODY in Young Men: the Role of Behavioral and Cardiometabolic Risk Factors in the Development of Complications

Rymar, O. D., Novosibirsk, R. F., Борисовна, Г. Р., Иванощук, Д. Е., Dolinskaya, Y. A., Dudina, M. V., Каширина, А. П., Ovsyannikova, A. K., Михайловна, М. П., Smoleusova, V. G., et al. (2024) · Doctor Ru · doi:10.31550/1727-2378-2024-23-4-60-66

Research Article Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness

Pedersen, O., Hansen, T., & Lebl, J. (2016)

Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase

(2016)

GCK Mutation in a Child with Maturity Onset Diabetes of the Young, Type 2.

Noorian, S., Sayarifard, F., Farhadi, E., Barbetti, F., & Rezaei, N. (2013) · Europe PMC (PubMed Central) · Cited by 4 · see citing works