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Multidimensional assessment of the cholesterol-HDL-glucose index identifies elevated risk of incident frailty in middle-aged and older adults: longitudinal evidence from CHARLS and ELSA

Zhang, Xicheng, Guo, Jiajie, Luo, Feng, Chen, Tianbao, Zheng, Danhua·2026·Diabetes Research and Clinical Practice
DOI 10.1016/j.diabres.2026.113653
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Research works printed but not linked: 37

  1. Kim, 2024, Frailty in older adults, N Engl J Med, 391, 538, 10.1056/NEJMra2301292 · DOI · Paper page
  2. Kojima, 2017, Frailty as a predictor of disabilities among community-dwelling older people: a systematic review and meta-analysis, Disabil Rehabil, 39, 1897, 10.1080/09638288.2016.1212282 · DOI · Paper page
  3. Yang, 2023, Frailty is a risk factor for falls in the older adults: a systematic review and meta-analysis, J Nutr Health Aging, 27, 487, 10.1007/s12603-023-1935-8 · DOI
  4. Li, 2025, Longitudinal changes in frailty and incident diabetes in middle-aged and older adults: evidence from CHARLS, Maturitas, 198, 10.1016/j.maturitas.2025.108375 · DOI
  5. Mishra, 2024, The intersection of frailty and metabolism, Cell Metab, 36, 893, 10.1016/j.cmet.2024.03.012 · DOI
  6. Si, 2025, Bidirectional relationship between diabetes and frailty in middle-aged and older adults: a systematic review and meta-analysis, Arch Gerontol Geriatr, 135, 10.1016/j.archger.2025.105880 · DOI
  7. Yang, 2024, The prevalence of frailty among patients with metabolic syndrome: a systematic review and meta-analysis, Contemp Nurse, 60, 479, 10.1080/10376178.2024.2360960 · DOI
  8. Pérez-Tasigchana, 2017, Metabolic syndrome and insulin resistance are associated with frailty in older adults: a prospective cohort study, Age Ageing, 46, 807, 10.1093/ageing/afx023 · DOI
  9. Mansoori, 2025, A novel index for diagnosis of type 2 diabetes mellitus: cholesterol, high density lipoprotein, and glucose (CHG) index, Journal of Diabetes Investigation, 16, 309, 10.1111/jdi.14343 · DOI
  10. Tian, 2026, Association of cumulative exposure to cholesterol, high-density lipoprotein, and glucose index with the risk of cardiovascular disease and all-cause mortality: a longitudinal cohort study, Diabetes Obes Metab, 28, 1453, 10.1111/dom.70338 · DOI
  11. Zhang, 2026, Association of cumulative cholesterol-HDL-glucose index with blood pressure changes and risk of new-onset hypertension in middle-aged and older adults: a cohort study, Cardiovasc Diabetol, 25, 49, 10.1186/s12933-026-03081-8 · DOI
  12. Chen, 2026, Association of baseline and cumulative CHG index with risk of new-onset sarcopenia in middle-aged and older adults, J Nutr Health Aging, 30, 10.1016/j.jnha.2026.100889 · DOI
  13. Zhang, 2026, Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis, Cardiovasc Diabetol, 25
  14. Zhang, 2026, Comparative discriminative performance of triglyceride-glucose derived composite indices and cholesterol-high-density lipoprotein cholesterol-glucose derived composite indices for identifying frailty: a cross-sectional study, Sci Prog, 109, 10.1177/00368504261459771 · DOI
  15. Zhao, 2014, Cohort profile: the China health and retirement longitudinal study (CHARLS), Int J Epidemiol, 43, 61, 10.1093/ije/dys203 · DOI · Paper page
  16. Steptoe, 2013, Cohort profile: the English longitudinal study of ageing, Int J Epidemiol, 42, 1640, 10.1093/ije/dys168 · DOI · Paper page
  17. Wang, 2026, Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS, Cardiovasc Diabetol, 25, 10.1186/s12933-026-03096-1 · doi:10.1186/s12933-026-03096-1
  18. Searle, 2008, A standard procedure for creating a frailty index, BMC Geriatr, 8, 24, 10.1186/1471-2318-8-24 · DOI · Paper page
  19. Fan, 2020, Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study, Lancet Public Health, 5, e650, 10.1016/S2468-2667(20)30113-4 · DOI · Paper page
  20. Villacampa-Fernández, 2017, Frailty and multimorbidity: two related yet different concepts, Maturitas, 95, 31, 10.1016/j.maturitas.2016.10.008 · DOI · Paper page
  21. Hoogendijk, 2019, Frailty: implications for clinical practice and public health, Lancet (London, England), 394, 1365, 10.1016/S0140-6736(19)31786-6 · DOI · Paper page
  22. Zhang, 2025, Diabetes is associated with impaired skeletal muscle quality, not quantity, in older adults, based on CT-derived chest muscle metrics, Maturitas, 202, 10.1016/j.maturitas.2025.108710 · DOI
  23. Soysal, 2017, Oxidative stress and frailty: a systematic review and synthesis of the best evidence, Maturitas, 99, 66, 10.1016/j.maturitas.2017.01.006 · DOI · Paper page
  24. Chen, 2026, Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study, Lipids Health Dis, 25, 52, 10.1186/s12944-026-02859-9 · DOI
  25. Hu, 2025, TyGi: a broad-spectrum clinical marker beyond CVD, Int J Cardiol, 420, 10.1016/j.ijcard.2024.132750 · doi:10.1016/j.ijcard.2024.132750
  26. Hu C. Combinatorial biomedicine: A novel discipline. Authorea [Internet]. Authorea; [cited 2026 Oct 17];2025. Doi: 10.22541/au.175573289.95969804/v1. · doi:10.22541/au.175573289.95969804/v1
  27. Lisco, 2023, Sarcopenia and diabetes: a detrimental liaison of advancing age, Nutrients, 16, 10.3390/nu16010063 · DOI
  28. Clegg, 2018, Frailty and the endocrine system, Lancet Diabetes Endocrinol, 6, 743, 10.1016/S2213-8587(18)30110-4 · DOI · Paper page
  29. Dondero, 2024, The effects of myosteatosis on skeletal muscle function in older adults, Physiol Rep, 12, 10.14814/phy2.16042 · DOI · Paper page
  30. Mengozzi, 2021, Microvascular ageing links metabolic disease to age-related disorders: the role of oxidative stress and inflammation in promoting microvascular dysfunction, J Cardiovasc Pharmacol, 78, S78, 10.1097/FJC.0000000000001109 · DOI
  31. Calila, 2024, Endothelial dysfunction as a key link between cardiovascular disease and frailty: a systematic review, J Clin Med, 13, 2686, 10.3390/jcm13092686 · DOI
  32. El Assar, 2024, Biomarkers of frailty, Mol Aspects Med, 97, 10.1016/j.mam.2024.101271 · DOI
  33. Long, 2025, Investigation of the association between the triglyceride-glucose index and the incidence of frailty among middle-aged and older adults: evidence from the China health and retirement longitudinal study, Front Public Health, 13, 10.3389/fpubh.2025.1548222 · DOI
  34. Wang, 2025, Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts, Cardiovasc Diabetol, 24, 81, 10.1186/s12933-025-02650-7 · DOI
  35. Dent, 2019, Physical frailty: ICFSR international clinical practice guidelines for identification and management, J Nutr Health Aging, 23, 771, 10.1007/s12603-019-1273-z · DOI · Paper page
  36. Lorbergs, 2022, Nutrition and physical activity clinical practice guidelines for older adults living with frailty, J Frailty Aging, 11, 3, 10.14283/jfa.2021.51 · DOI
  37. Hu, 2018, Grants supporting research in China, Eur Heart J, 39, 2342, 10.1093/eurheartj/ehy293 · DOI

Metadata

Authors
Zhang, X., Guo, J., Luo, F., Chen, T., & Zheng, D.
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
2026-11
Pages
113653
ISSN
0168-8227
DOI
10.1016/j.diabres.2026.113653
Cited by
0
Language
en
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CoChat. (2026). Citation check: Multidimensional assessment of the cholesterol-HDL-glucose index identifies elevated risk of incident frailty in middle-aged and older adults: longitudinal evidence from CHARLS and ELSA. https://app.cochat.ai/papers/10.1016/j.diabres.2026.113653
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Zhang, X., Guo, J., Luo, F., Chen, T., & Zheng, D. (2026). Multidimensional assessment of the cholesterol-HDL-glucose index identifies elevated risk of incident frailty in middle-aged and older adults: longitudinal evidence from CHARLS and ELSA. Diabetes Research and Clinical Practice. https://doi.org/10.1016/j.diabres.2026.113653

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.