The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Time to positive culture and identification for Candida blood stream infections
Abstract
Candidemia and delay to appropriate therapy contribute to increased morbidity and mortality. Current literature addresses the delay between blood culture collection and final identification; however, it fails to delineate differences among species. The purpose of this study was to quantify the time to yeast detection and identification relative to blood culture collection and determine whether differences exist among species. In this retrospective study, all cases of Candida isolation for 2 years were reviewed. The time delays between blood culture and detection of Candida growth were quantified as well as the additional time required for final species identification. Initiation of antifungal therapy was assessed in relation to culture collection, detection of yeast, and final identification. The appropriateness of therapy at each time point was also analyzed. Most Candida infections were caused by either Candida albicans (n = 43) or Candida glabrata (n = 27). Mean time to positive yeast detection for C. albicans was 35.3 +/- 18.1 h, whereas that of C. glabrata was 80.0 +/- 22.4 h (P < 0.0001). Mean time to final identification for C. albicans was 85.8 +/- 30.9, whereas that of C. glabrata was 154 +/- 43.8 h (P < 0.0001). Mean time to appropriate therapy for C. albicans isolates was 43.3 +/- 27.6 h compared with 98.1 +/- 38.3 h (P < 0.0001) for C. glabrata isolates. The time delay between blood culture collection and yeast detection as well as final identification was significantly longer for C. glabrata isolates when compared with C. albicans. As a result, mean time to appropriate antifungal therapy was significantly longer in patients with C. glabrata isolates.
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“In this study, the time to appropriate therapy for C albicans isolates was 43.3 Æ 27.6 hours compared with 98.1 Æ 38.3 hours for C glabrata isolates.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]
In the citing paper
“Furthermore, detection of candidemia by blood culture often takes more than 24 hours.For certain species, such as C glabrata, the time to positive culture can be even longer.[56][57][58][59][60]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]
In the citing paper
“Mean time to final identification to species level for C albicans was 85.8 Æ 30.9 hours compared with 154 Æ 43.8 hours for C glabrata.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]
In the citing paper
“In a study by Fernandez and colleagues, 56 the mean time to yeast detection in blood cultures for C albicans was 35.3 Æ 18.1 hours, whereas that of C glabrata was 80.0 Æ 22.4 hours.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [56]
Citations
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Economic Impact of Candida Colonization and Candida Infection in the Critically Ill Patient
Jord�, R., Nolla‐Salas, J., Le�n-Regidor, M. A., lvarez-Lerma, F., Olaechea, P., Palomar, M., & Le�n-Gil, C. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1104-x · Cited by 130
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Metadata
- Authors
- Fernandez, J., Erstad, B. L., Petty, W., & Nix, D. E.
- Affiliations
- University of Arizona (US)
- Corresponding author
- Nix, David E.
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 64
- Issue
- 4
- Pages
- 402-407
- ISSN
- 0732-8893 (ISSN-L)
- OpenAlex
- W2033083353
- Cited by
- 106
- References
- 16
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 7
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diagnostic Microbiology and Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- candidemia, Candida albicans, Candida glabrata, yeast identification, treatment delay, fungemia
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antifungal Agents, Blood, Candida albicans, Candidiasis, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Time Factors, Fungemia, Candida glabrata, Young Adult
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