National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units
Abstract
Candida species are the fourth most frequent cause of nosocomial bloodstream infections, and 25%-50% occur in critical care units. During an 18-month prospective study period, all patients admitted for > or = 72 hours to the surgical (SICUs) or neonatal intensive care units (NICUs) at each of the participant institutions were followed daily. Among 4,276 patients admitted to the seven SICUs in six centers, there were 42 nosocomial bloodstream infections due to Candida species (9.8/1,000 admissions; 0.99/1,000 patient-days). Of 2,847 babies admitted to the six NICUs, 35 acquired a nosocomial bloodstream infection due to Candida species (12.3/1,000 admissions; 0.64/1,000 patient-days). The following were the most commonly isolated Candida species causing bloodstream infections in the SICU: Candida albicans, 48%; Candida glabrata, 24%; Candida tropicalis, 19%; Candida parapsilosis, 7%; Candida species not otherwise specified, 2%. In the NICU the distribution was as follows: C. albicans, 63%; C. glabrata, 6%; C. parapsilosis, 29%; other, 3%. Of the patients, 30%-50% developed incidental stool colonization, 23% of SICU patients developed incidental urine colonization, and one-third of SICU health care workers' hands were positive for Candida species.
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Currently, Candida albicans accounts for less than 50% of all Candida bloodstream infections.
“Presently, C albicans accounts for less than 50% of all BSIs caused by the Candida genus.3,[26][27][28][29][30]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [27]
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- Authors
- Rangel‐Frausto, M. S., Wiblin, T., Blumberg, H. M., Saiman, L., Patterson, J., Rinaldi, M., Pfaller, M., Edwards, Jr., Jarvis, W., Dawson, J., Wenzel, R. P., & the NEMIS Study Group
- Affiliations
- University of Iowa (US)
- Corresponding author
- Wenzel, Richard P.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 29
- Issue
- 2
- Pages
- 253-258
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2139728976
- Cited by
- 430
- References
- 28
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 17
- FWCI
- 18.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- Candida species, bloodstream infection, nosocomial infections, surgical intensive care unit, neonatal intensive care unit, Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, fungal colonization
- MeSH terms
- Candidiasis, Health Personnel, Health Surveys, Humans, Intensive Care Units, Prospective Studies, United States, Intensive Care Units, Pediatric, Fungemia, Infectious Disease Transmission, Patient-to-Professional
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