The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Scar-free wound healing and regeneration in amphibians: Immunological influences on regenerative success
Open accessAbstract
Salamanders and frogs are distinct orders of Amphibians with very different immune systems during adult life, exhibiting varying potential for scar free repair and regeneration. While salamanders can regenerate a range of body parts throughout all stages of life, regeneration is restricted to early stages of frog development. Comparison of these two closely related amphibian orders provides insights into the immunological influences on wound repair, and the different strategies that have evolved either to limit infection or to facilitate efficient regeneration. After injury, cells of the immune system are responsible for the removal of damaged cells and providing a cohort of important growth factors and signaling molecules. Immune cells not only regulate new vessel growth important for supplying essential nutrients to damaged tissue but, modulate the extracellular matrix environment by regulating fibroblasts and the scarring response. The profile of immune cell infiltration and their interaction with local tissue immune cells directly influences many aspects of the wound healing outcomes and can facilitate or prevent regeneration. Evidence is emerging that the transition from wound healing to regeneration is reliant on immune cell engagement and that the success of regeneration in amphibians may depend on complex interactions between stem cell progenitors and immune cell subsets. The potential immunological barriers to mammalian regeneration are discussed with implications for the successful delivery of stem cell therapeutic strategies in patients.
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Citations
Cites
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 1×
“Complement comprises a group of circulating proteins that forms part of the innate immune system and is primarily involved in the recognition and clearance of pathogens from an organism (reviewed in Ricklin et al. (2010), Sarma and Ward (2011)).”
BackgroundDifferential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1×
“Macrophages also interact with the adaptive immune cells to modulate the function of fibroblasts and are considered the master regulators of fibrosis and scar tissue formation (Wynn and Barron, 2010; Lucas et al., 2010).”
BackgroundMicroglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757
Ruffell, D., Mourkioti, F., Gambardella, A., Kirstetter, P., Lopez, R. G., Rosenthal, N., & Nerlov, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908641106 · Cited by 626
Self-citationFetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold, J. E., Venkatasubrahmanyam, S., Burt, T. D., Michaëlsson, J., Rivera, J. M., Galkina, S. A., Weinberg, K., Stoddart, C. A., & McCune, J. M. (2010) · Science · doi:10.1126/science.1196509 · Cited by 444
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“…in regeneration has been confirmed in other regenerative animal models such as zebrafish: ablation of macrophages but not neutrophils severely impaired the inflammatory resolution and tissue regeneration, resulting in the formation of large vacuoles in the regenerated fins (Li et al., 2012).”
BackgroundResultNerve dependence in tissue, organ, and appendage regeneration
Kumar, A., & Brockes, J. P. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.003 · Cited by 290
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration
Haynes, T., Luz-Madrigal, A., Reis, E. S., Echeverri Ruiz, N. P., Grajales-Esquivel, E., Tzekou, A., Tsonis, P. A., Lambris, J. D., & Del Rio-Tsonis, K. (2013) · Nature Communications · doi:10.1038/ncomms3312 · Cited by 87
Cited by
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Mechanisms of Cardiac Regeneration
Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 286
Metadata
- Authors
- Godwin, J. W., & Rosenthal, N.
- Venue
- Differentiation
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 87
- Issue
- 1-2
- Pages
- 66-75
- ISSN
- 0301-4681 (ISSN-L)
- OpenAlex
- W2044555092
- Cited by
- 191
- References
- 8
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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