The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial
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“Across the above studies, sex-stratified efficacy results were not reported [29,30,31,32].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [29]
In the citing paper
“Clinical trials conducted before the Rome IV criteria showed that a 4-week treatment with peppermint oil (two capsules twice daily) improved IBS abdominal symptoms compared with placebo (p < 0.009) in a prospective double blind randomized controlled trial [29]”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [29]
In the citing paper
“Regarding adverse events, no serious events were reported; those observed were mild and transient, including heartburn [29,31,32], belching with minty taste [31], peppermint-oil-scented stool [31] and hypersensitivity/eczema [32].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [29]
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Citations
Cites
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Small Intestinal Bacterial Overgrowth: A Framework for Understanding Irritable Bowel Syndrome
Lin, H. C. (2004) · JAMA · doi:10.1001/jama.292.7.852 · Cited by 396
Research works printed but not linked: 26
- Frissora, 2005, Symptom overlap and comorbidity of irritable bowel syndrome with other conditions, Curr Gastroenterol Rep, 7, 264, 10.1007/s11894-005-0018-9 · DOI
- Pimentel, 2003, Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption, Am J Gastroenterol, 98, 2700, 10.1111/j.1572-0241.2003.08670.x · DOI
- Vernia, 2001, Lactose malabsorption, irritable bowel syndrome and self-reported milk intolerance, Dig Liver Dis, 33, 234, 10.1016/S1590-8658(01)80713-1 · DOI
- Ojetti, 2005, High prevalence of celiac disease in patients with lactose intolerance, Digestion, 71, 106, 10.1159/000084526 · DOI
- De Giorgio, 2004, Diagnosis and therapy of irritable bowel syndrome, Aliment Pharmacol Ther, 20, 10, 10.1111/j.1365-2036.2004.02038.x · DOI
- Kline, 2001, Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children, J Pediatr, 138, 125, 10.1067/mpd.2001.109606 · DOI · Paper page
- Liu, 1997, Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial, J Gastroenterol, 32, 765, 10.1007/BF02936952 · DOI · Paper page
- Pittler, 1998, Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis, Am J Gastroenterol, 93, 1131, 10.1111/j.1572-0241.1998.00343.x · DOI · Paper page
- Ringel, 2001, Irritable bowel syndrome, Annu Rev Med, 52, 319, 10.1146/annurev.med.52.1.319 · DOI
- Lesbros-Pantoflickova, 2004, Meta-analysis: the treatment of irritable bowel syndrome, Aliment Pharmacol Ther, 20, 1253, 10.1111/j.1365-2036.2004.02267.x · DOI
- Hussain, 2006, Systematic review: complementary and alternative medicine in the irritable bowel syndrome, Aliment Pharmacol Ther, 23, 465, 10.1111/j.1365-2036.2006.02776.x · DOI
- Nash, 1986, Peppermint oil does not relieve the pain of irritable bowel syndrome, Br J Clin Pract, 40, 292, 10.1111/j.1742-1241.1986.tb07981.x · DOI
- Carling, 1989, Short term treatment of the irritable bowel syndrome: a placebo-controlled trial of peppermint oil against hyoschamine, OPMEAR, 34, 55
- Dew, 1984, Peppermint oil for the irritable bowel syndrome: a multicentre trial, Br J Clin Pract, 38, 394, 10.1111/j.1742-1241.1984.tb07744.x · DOI
- Lech, 1988, Treatment of irritable bowel syndrome with peppermint oil. A double-blind study with a placebo, Ugeskr Laeger, 150, 2388
- Rees, 1979, Treating irritable bowel syndrome with peppermint oil, Br Med J, 6194, 835, 10.1136/bmj.2.6194.835 · DOI
- Farup, 2004, Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case-control study, Scand J Gastroenterol, 39, 645, 10.1080/00365520410005405 · DOI
- Peralta, 2006, Small intestinal bacterial overgrowth: a new face of irritable bowel syndrome?, Dig Liver Dis, 38, S203, 10.1016/S1590-8658(06)80552-9 · DOI
- Hills, 1991, The mechanism of action of peppermint oil on gastrointestinal smooth muscle, Gastroenterology, 101, 55, 10.1016/0016-5085(91)90459-X · DOI
- Grigoleit, 2005, Gastrointestinal clinical pharmacology of peppermint oil, Phytomedicine, 12, 607, 10.1016/j.phymed.2004.10.006 · DOI
- Snape, 1997, Role of colonic motility in guiding therapy in patients with constipation, Dig Dis, 15, 104, 10.1159/000171625 · DOI
- Nobaek, 2000, Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome, Am J Gastroenterol, 95, 1231, 10.1111/j.1572-0241.2000.02015.x · DOI · Paper page
- Pimentel, 2003, Methane production during lactulose breath test is associated with gastrointestinal disease presentation, Dig Dis Sci, 48, 86, 10.1023/A:1021738515885 · DOI
- Logan, 2002, The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report, Altern Med Rev, 7, 410
- Whorwell, 2006, Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome, Am J Gastroenterol, 101, 1581, 10.1111/j.1572-0241.2006.00734.x · DOI · Paper page
- Santos Ocampo, 1993, A randomized double-blind clinical trial of a maltodextrin-containing oral rehydration solution in acute infantile diarrhea, J Pediatr Gastroenterol Nutr, 16, 23, 10.1097/00005176-199301000-00004 · DOI
Cited by
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866
Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine
Saha, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6759 · Cited by 500
American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome
Ford, A. C., Moayyedi, P., Chey, W. D., Harris, L. A., Lacy, B. E., Saito, Y. A., & Quigley, E. M. M. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0084-x · Cited by 388
Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome
Ruepert, L., Quartero, A. O., de Wit, N. J., van der Heijden, G. J., Rubin, G., & Muris, J. W. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003460.pub3 · Cited by 389
An Evidence-Based Systematic Review on the Management of Irritable Bowel Syndrome
Brandt, L. J., Chey, W. D., Foxx-Orenstein, A. E., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P. S., Spiegel, B. M., Talley, N. J., & Moayyedi, P. (2009) · American Journal of Gastroenterology · doi:10.14309/00000434-200901001-00002 · Cited by 225
Metadata
- Authors
- Cappello, G., Spezzaferro, M., Grossi, L., Manzoli, L., & Marzio, L.
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 39
- Issue
- 6
- Pages
- 530-536
- ISSN
- 1590-8658
- Cited by
- 160
- References
- 2
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- CoChat. (2026). Citation check: Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial. https://app.cochat.ai/papers/10.1016/j.dld.2007.02.006
- The paper
- Cappello, G., Spezzaferro, M., Grossi, L., Manzoli, L., & Marzio, L. (2007). Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial. Digestive and Liver Disease. https://doi.org/10.1016/j.dld.2007.02.006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
